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Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
Diabetes Res Clin Pract. 2008 Apr; 80(1):40-7.DR

Abstract

Keishibukuryogan, one of the traditional herbal formulations, is used clinically to improve blood circulation. In this study, we examined the effects of keishibukuryogan on glucose and lipids metabolism in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. Forty-five-week-old male OLETF rats were divided into three groups: diabetic control rats given a standard chow; diabetic rats given keishibukuryogan (3%, w/w in chow); diabetic rats given pioglitazone (0.01%, w/w in chow). Oral administration of keishibukuryogan produced significant improvement against impaired glucose tolerance. On the other hand, fasting serum glucose and insulin levels, and the homeostasis index of insulin resistance did not change by keishibukuryogan treatment. Against lipid parameters, keishibukuryogan significantly lowered serum total cholesterol and triglyceride levels, and the hepatic total cholesterol level. Keishibukuryogan treatment also significantly reduced the serum leptin level, but it had no effect on the serum adiponectin level. Additionally, keishibukuryogan showed significant effects on epididymal adipose tissue by decreasing the size of fat cells and on skeletal muscle by reducing TNF-alpha protein content. From these results, it was suggested that keishibukuryogan exerts beneficial effects on the features associated with type 2 diabetes.

Authors+Show Affiliations

Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. takako26@med.u-toyama.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18242756

Citation

Nakagawa, Takako, et al. "Keishibukuryogan Ameliorates Glucose Intolerance and Hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats." Diabetes Research and Clinical Practice, vol. 80, no. 1, 2008, pp. 40-7.
Nakagawa T, Goto H, Hussein G, et al. Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Diabetes Res Clin Pract. 2008;80(1):40-7.
Nakagawa, T., Goto, H., Hussein, G., Hikiami, H., Shibahara, N., & Shimada, Y. (2008). Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Diabetes Research and Clinical Practice, 80(1), 40-7. https://doi.org/10.1016/j.diabres.2007.11.019
Nakagawa T, et al. Keishibukuryogan Ameliorates Glucose Intolerance and Hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats. Diabetes Res Clin Pract. 2008;80(1):40-7. PubMed PMID: 18242756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. AU - Nakagawa,Takako, AU - Goto,Hirozo, AU - Hussein,Ghazi, AU - Hikiami,Hiroaki, AU - Shibahara,Naotoshi, AU - Shimada,Yutaka, Y1 - 2008/02/01/ PY - 2007/05/01/received PY - 2007/11/19/accepted PY - 2008/2/5/pubmed PY - 2008/6/24/medline PY - 2008/2/5/entrez SP - 40 EP - 7 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 80 IS - 1 N2 - Keishibukuryogan, one of the traditional herbal formulations, is used clinically to improve blood circulation. In this study, we examined the effects of keishibukuryogan on glucose and lipids metabolism in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. Forty-five-week-old male OLETF rats were divided into three groups: diabetic control rats given a standard chow; diabetic rats given keishibukuryogan (3%, w/w in chow); diabetic rats given pioglitazone (0.01%, w/w in chow). Oral administration of keishibukuryogan produced significant improvement against impaired glucose tolerance. On the other hand, fasting serum glucose and insulin levels, and the homeostasis index of insulin resistance did not change by keishibukuryogan treatment. Against lipid parameters, keishibukuryogan significantly lowered serum total cholesterol and triglyceride levels, and the hepatic total cholesterol level. Keishibukuryogan treatment also significantly reduced the serum leptin level, but it had no effect on the serum adiponectin level. Additionally, keishibukuryogan showed significant effects on epididymal adipose tissue by decreasing the size of fat cells and on skeletal muscle by reducing TNF-alpha protein content. From these results, it was suggested that keishibukuryogan exerts beneficial effects on the features associated with type 2 diabetes. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/18242756/Keishibukuryogan_ameliorates_glucose_intolerance_and_hyperlipidemia_in_Otsuka_Long_Evans_Tokushima_Fatty__OLETF__rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(07)00615-8 DB - PRIME DP - Unbound Medicine ER -