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Chronic stress, salivary cortisol, and alpha-amylase in children with asthma and healthy children.
Biol Psychol. 2008 Apr; 78(1):20-8.BP

Abstract

The present study examined whether chronic stress is related to daily life levels of salivary alpha-amylase (sAA), a marker for sympathetic activity, and cortisol in healthy children versus children with asthma. Children's sAA and cortisol levels were measured repeatedly over 2 days. Chronic stress measures included interviews with children about chronic home life stress and interviews with parents about one marker of socioeconomic status, parental education. Among children with asthma, higher chronic stress was associated with lower daily sAA output, while among healthy children, higher chronic stress was associated with flatter cortisol slopes. In conclusion, chronically stressed children with asthma showed lower salivary alpha-amylase output, indicating lower sympathetic activity, and implying a possible mechanism for increased susceptibility to symptom exacerbations. In contrast, higher cortisol levels in healthy children with chronic stress may indicate, for example, an increased risk for infectious diseases. This dichotomy emphasizes the different biological effects of chronic stress depending on illness status.

Authors+Show Affiliations

University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada. juttawolf@psych.ubc.ca <juttawolf@psych.ubc.ca>No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18243483

Citation

Wolf, Jutta M., et al. "Chronic Stress, Salivary Cortisol, and Alpha-amylase in Children With Asthma and Healthy Children." Biological Psychology, vol. 78, no. 1, 2008, pp. 20-8.
Wolf JM, Nicholls E, Chen E. Chronic stress, salivary cortisol, and alpha-amylase in children with asthma and healthy children. Biol Psychol. 2008;78(1):20-8.
Wolf, J. M., Nicholls, E., & Chen, E. (2008). Chronic stress, salivary cortisol, and alpha-amylase in children with asthma and healthy children. Biological Psychology, 78(1), 20-8. https://doi.org/10.1016/j.biopsycho.2007.12.004
Wolf JM, Nicholls E, Chen E. Chronic Stress, Salivary Cortisol, and Alpha-amylase in Children With Asthma and Healthy Children. Biol Psychol. 2008;78(1):20-8. PubMed PMID: 18243483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic stress, salivary cortisol, and alpha-amylase in children with asthma and healthy children. AU - Wolf,Jutta M, AU - Nicholls,Erin, AU - Chen,Edith, Y1 - 2007/12/23/ PY - 2007/10/06/received PY - 2007/12/11/revised PY - 2007/12/12/accepted PY - 2008/2/5/pubmed PY - 2008/7/11/medline PY - 2008/2/5/entrez SP - 20 EP - 8 JF - Biological psychology JO - Biol Psychol VL - 78 IS - 1 N2 - The present study examined whether chronic stress is related to daily life levels of salivary alpha-amylase (sAA), a marker for sympathetic activity, and cortisol in healthy children versus children with asthma. Children's sAA and cortisol levels were measured repeatedly over 2 days. Chronic stress measures included interviews with children about chronic home life stress and interviews with parents about one marker of socioeconomic status, parental education. Among children with asthma, higher chronic stress was associated with lower daily sAA output, while among healthy children, higher chronic stress was associated with flatter cortisol slopes. In conclusion, chronically stressed children with asthma showed lower salivary alpha-amylase output, indicating lower sympathetic activity, and implying a possible mechanism for increased susceptibility to symptom exacerbations. In contrast, higher cortisol levels in healthy children with chronic stress may indicate, for example, an increased risk for infectious diseases. This dichotomy emphasizes the different biological effects of chronic stress depending on illness status. SN - 0301-0511 UR - https://www.unboundmedicine.com/medline/citation/18243483/Chronic_stress_salivary_cortisol_and_alpha_amylase_in_children_with_asthma_and_healthy_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-0511(07)00201-3 DB - PRIME DP - Unbound Medicine ER -