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The comparison of single-dose ceftriaxone, five-day azithromycin, and ten-day amoxicillin/clavulanate for the treatment of children with acute otitis media.
Turk J Pediatr 2007 Oct-Dec; 49(4):390-6TJ

Abstract

The aim of the study was to evaluate the efficacy of short-course antimicrobial therapies [single intramuscular dose of ceftriaxone (50 mg/kg, not exceeding 1 g), 5 days of azithromycin (10 mg/kg on day 1, then 5 mg/kg daily on days 2-5) and the traditional 10-day course of amoxicillin/clavulanate (90/6.4 mg/kg/day in 2 doses)] in children with acute otitis media (AOM). The study was conducted as a prospective, comparative, open randomized trial between February 2001 and April 2003, and 104 children were enrolled, with a mean age of 3.8 (2.3) years. The clinical and otoscopic assessments of the children were made on days 0, 3, 11 and 30 after admission, and tympanometry was performed on day 30. The patients were diagnosed and followed with a scoring system. Clinical success was achieved in 29/34 patients (85.3%) in the ceftriaxone group, 27/31 patients (87.1%) in the azithromycin group and 34/39 children (87.2%) in the amoxicillin/clavulanate group. The rate of persistence of middle-ear fluid did not differ between the three groups (p>0.05). During the one-month period, no recurrent case was observed. The most common drug-related adverse effects were associated with the gastrointestinal system. In conclusion, for the treatment of children with AOM, the clinical success of single-dose intramuscular ceftriaxone and of five-day azithromycin treatments was comparable to that of the traditional 10-day therapy with high-dose amoxicillin/clavulanate.

Authors+Show Affiliations

Department of Pediatrics, Trakya University Faculty of Medicine, Edirne, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18246740

Citation

Biner, Betül, et al. "The Comparison of Single-dose Ceftriaxone, Five-day Azithromycin, and Ten-day Amoxicillin/clavulanate for the Treatment of Children With Acute Otitis Media." The Turkish Journal of Pediatrics, vol. 49, no. 4, 2007, pp. 390-6.
Biner B, Celtik C, Oner N, et al. The comparison of single-dose ceftriaxone, five-day azithromycin, and ten-day amoxicillin/clavulanate for the treatment of children with acute otitis media. Turk J Pediatr. 2007;49(4):390-6.
Biner, B., Celtik, C., Oner, N., Küçükuğurluoğlu, Y., Güzel, A., Yildirim, C., & Adali, M. K. (2007). The comparison of single-dose ceftriaxone, five-day azithromycin, and ten-day amoxicillin/clavulanate for the treatment of children with acute otitis media. The Turkish Journal of Pediatrics, 49(4), pp. 390-6.
Biner B, et al. The Comparison of Single-dose Ceftriaxone, Five-day Azithromycin, and Ten-day Amoxicillin/clavulanate for the Treatment of Children With Acute Otitis Media. Turk J Pediatr. 2007;49(4):390-6. PubMed PMID: 18246740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The comparison of single-dose ceftriaxone, five-day azithromycin, and ten-day amoxicillin/clavulanate for the treatment of children with acute otitis media. AU - Biner,Betül, AU - Celtik,Coşkun, AU - Oner,Naci, AU - Küçükuğurluoğlu,Yasemin, AU - Güzel,Ahmet, AU - Yildirim,Cetin, AU - Adali,Mustafa Kemal, PY - 2008/2/6/pubmed PY - 2008/2/28/medline PY - 2008/2/6/entrez SP - 390 EP - 6 JF - The Turkish journal of pediatrics JO - Turk. J. Pediatr. VL - 49 IS - 4 N2 - The aim of the study was to evaluate the efficacy of short-course antimicrobial therapies [single intramuscular dose of ceftriaxone (50 mg/kg, not exceeding 1 g), 5 days of azithromycin (10 mg/kg on day 1, then 5 mg/kg daily on days 2-5) and the traditional 10-day course of amoxicillin/clavulanate (90/6.4 mg/kg/day in 2 doses)] in children with acute otitis media (AOM). The study was conducted as a prospective, comparative, open randomized trial between February 2001 and April 2003, and 104 children were enrolled, with a mean age of 3.8 (2.3) years. The clinical and otoscopic assessments of the children were made on days 0, 3, 11 and 30 after admission, and tympanometry was performed on day 30. The patients were diagnosed and followed with a scoring system. Clinical success was achieved in 29/34 patients (85.3%) in the ceftriaxone group, 27/31 patients (87.1%) in the azithromycin group and 34/39 children (87.2%) in the amoxicillin/clavulanate group. The rate of persistence of middle-ear fluid did not differ between the three groups (p>0.05). During the one-month period, no recurrent case was observed. The most common drug-related adverse effects were associated with the gastrointestinal system. In conclusion, for the treatment of children with AOM, the clinical success of single-dose intramuscular ceftriaxone and of five-day azithromycin treatments was comparable to that of the traditional 10-day therapy with high-dose amoxicillin/clavulanate. SN - 0041-4301 UR - https://www.unboundmedicine.com/medline/citation/18246740/The_comparison_of_single_dose_ceftriaxone_five_day_azithromycin_and_ten_day_amoxicillin/clavulanate_for_the_treatment_of_children_with_acute_otitis_media_ L2 - http://www.diseaseinfosearch.org/result/7025 DB - PRIME DP - Unbound Medicine ER -