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Omega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo-controlled trial.
Aust N Z J Psychiatry. 2008 Mar; 42(3):199-205.AN

Abstract

OBJECTIVE

Epidemiological, biological marker and treatment studies, as well as neuroscientific theories, indicate a possible link between omega-3 fatty acids and perinatal depression (PND). Hence the aim of the present study was to assess whether omega-3 fatty acid treatment is superior to placebo in the treatment of PND.

METHOD

A double-blind randomized placebo-controlled trial was undertaken. Women with major depression during the perinatal period received either fish oil or placebo for six weeks. Changes in depression scores were recorded weekly.

RESULTS

A total of 26 subjects were recruited and there was no significant difference in depression scores between those receiving fish oil and those receiving the placebo.

CONCLUSIONS

This is formally a negative study, suggesting that there is no benefit for omega-3 fatty acids over placebo in treating PND. The reason could be that the study was underpowered due to recruitment difficulties and therefore we suggest that it may be unwise to interpret this result as conclusive. Omega-3 is a natural product that is a safe and well-tolerated treatment. Further research is therefore needed in this area to establish whether omega-3 fatty acids are an effective treatment for PND.

Authors+Show Affiliations

Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia. a.rees@unsw.edu.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18247194

Citation

Rees, Anne-Marie, et al. "Omega-3 Fatty Acids as a Treatment for Perinatal Depression: Randomized Double-blind Placebo-controlled Trial." The Australian and New Zealand Journal of Psychiatry, vol. 42, no. 3, 2008, pp. 199-205.
Rees AM, Austin MP, Parker GB. Omega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo-controlled trial. Aust N Z J Psychiatry. 2008;42(3):199-205.
Rees, A. M., Austin, M. P., & Parker, G. B. (2008). Omega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo-controlled trial. The Australian and New Zealand Journal of Psychiatry, 42(3), 199-205. https://doi.org/10.1080/00048670701827267
Rees AM, Austin MP, Parker GB. Omega-3 Fatty Acids as a Treatment for Perinatal Depression: Randomized Double-blind Placebo-controlled Trial. Aust N Z J Psychiatry. 2008;42(3):199-205. PubMed PMID: 18247194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo-controlled trial. AU - Rees,Anne-Marie, AU - Austin,Marie-Paule, AU - Parker,Gordon B, PY - 2008/2/6/pubmed PY - 2008/6/12/medline PY - 2008/2/6/entrez SP - 199 EP - 205 JF - The Australian and New Zealand journal of psychiatry JO - Aust N Z J Psychiatry VL - 42 IS - 3 N2 - OBJECTIVE: Epidemiological, biological marker and treatment studies, as well as neuroscientific theories, indicate a possible link between omega-3 fatty acids and perinatal depression (PND). Hence the aim of the present study was to assess whether omega-3 fatty acid treatment is superior to placebo in the treatment of PND. METHOD: A double-blind randomized placebo-controlled trial was undertaken. Women with major depression during the perinatal period received either fish oil or placebo for six weeks. Changes in depression scores were recorded weekly. RESULTS: A total of 26 subjects were recruited and there was no significant difference in depression scores between those receiving fish oil and those receiving the placebo. CONCLUSIONS: This is formally a negative study, suggesting that there is no benefit for omega-3 fatty acids over placebo in treating PND. The reason could be that the study was underpowered due to recruitment difficulties and therefore we suggest that it may be unwise to interpret this result as conclusive. Omega-3 is a natural product that is a safe and well-tolerated treatment. Further research is therefore needed in this area to establish whether omega-3 fatty acids are an effective treatment for PND. SN - 0004-8674 UR - https://www.unboundmedicine.com/medline/citation/18247194/Omega_3_fatty_acids_as_a_treatment_for_perinatal_depression:_randomized_double_blind_placebo_controlled_trial_ L2 - https://journals.sagepub.com/doi/10.1080/00048670701827267?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -