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Upper limit of serum ferritin: misinterpretation of the 2006 KDOQI anemia guidelines.
Semin Dial. 2008 May-Jun; 21(3):217-20.SD

Abstract

Intravenous iron treatment in hemodialysis patients improves response to recombinant human erythropoietin and facilitates achievement of targets for hemoglobin and hematocrit. Excessive treatment, however, could expose patients to risks related to iron overload and oxidative stress. Therefore, international treatment guidelines generally recommend that intravenous (i.v.) iron be discontinued when serum ferritin is >500-1,000 ng/ml. In the current review, relevant issues that inform decisions as to what levels of serum ferritin should be used as the upper limit for treatment are considered. A conclusion is reached that the current published literature is inadequate for developing evidence-based guidelines on this issue. Instead, clinical judgment is critical to properly weigh risks and benefits of i.v. iron treatment, and to determine whether iron treatment is appropriate for a given patient with higher levels of iron tests.

Authors

No affiliation info available

Pub Type(s)

Editorial
Review

Language

eng

PubMed ID

18248518

Citation

Fishbane, Steven. "Upper Limit of Serum Ferritin: Misinterpretation of the 2006 KDOQI Anemia Guidelines." Seminars in Dialysis, vol. 21, no. 3, 2008, pp. 217-20.
Fishbane S. Upper limit of serum ferritin: misinterpretation of the 2006 KDOQI anemia guidelines. Semin Dial. 2008;21(3):217-20.
Fishbane, S. (2008). Upper limit of serum ferritin: misinterpretation of the 2006 KDOQI anemia guidelines. Seminars in Dialysis, 21(3), 217-20. https://doi.org/10.1111/j.1525-139X.2007.00420.x
Fishbane S. Upper Limit of Serum Ferritin: Misinterpretation of the 2006 KDOQI Anemia Guidelines. Semin Dial. 2008 May-Jun;21(3):217-20. PubMed PMID: 18248518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Upper limit of serum ferritin: misinterpretation of the 2006 KDOQI anemia guidelines. A1 - Fishbane,Steven, Y1 - 2008/02/01/ PY - 2008/2/6/pubmed PY - 2008/11/1/medline PY - 2008/2/6/entrez SP - 217 EP - 20 JF - Seminars in dialysis JO - Semin Dial VL - 21 IS - 3 N2 - Intravenous iron treatment in hemodialysis patients improves response to recombinant human erythropoietin and facilitates achievement of targets for hemoglobin and hematocrit. Excessive treatment, however, could expose patients to risks related to iron overload and oxidative stress. Therefore, international treatment guidelines generally recommend that intravenous (i.v.) iron be discontinued when serum ferritin is >500-1,000 ng/ml. In the current review, relevant issues that inform decisions as to what levels of serum ferritin should be used as the upper limit for treatment are considered. A conclusion is reached that the current published literature is inadequate for developing evidence-based guidelines on this issue. Instead, clinical judgment is critical to properly weigh risks and benefits of i.v. iron treatment, and to determine whether iron treatment is appropriate for a given patient with higher levels of iron tests. SN - 0894-0959 UR - https://www.unboundmedicine.com/medline/citation/18248518/Upper_limit_of_serum_ferritin:_misinterpretation_of_the_2006_KDOQI_anemia_guidelines_ L2 - https://doi.org/10.1111/j.1525-139X.2007.00420.x DB - PRIME DP - Unbound Medicine ER -