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A multi-site validation trial of radioactive seed localization as an alternative to wire localization.
Breast J 2008 Mar-Apr; 14(2):153-7BJ

Abstract

This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated with RSL. Margins were considered "negative" if > or =2 mm from in-situ and invasive disease. Pain and convenience scores were recorded on a 10-point scale. Patient characteristics and histology were similar. The lesion and localization device were retrieved in all patients. Margins of the first specimen were negative in 73% of RSL patients, versus 54% of WL patients (p < 0.001). A second operation was required in 8% of RSL patients to achieve negative margins, versus 25% of WL patients (p < 0.001). Pain scores were not statistically different. However, the RSL group had higher convenience scores (p = 0.015). RSL is safe, effective, and compared to WL, reduces the rates of intraoperative re-excision and reoperation for positive margins by 68%. Patient satisfaction is improved with RSL. We strongly favor RSL over WL.

Authors+Show Affiliations

Department of Surgery, Mayo Clinic, Scottsdale, Arizona 85259, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Validation Study

Language

eng

PubMed ID

18248562

Citation

Hughes, Jenevieve H., et al. "A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization." The Breast Journal, vol. 14, no. 2, 2008, pp. 153-7.
Hughes JH, Mason MC, Gray RJ, et al. A multi-site validation trial of radioactive seed localization as an alternative to wire localization. Breast J. 2008;14(2):153-7.
Hughes, J. H., Mason, M. C., Gray, R. J., McLaughlin, S. A., Degnim, A. C., Fulmer, J. T., ... Roarke, M. C. (2008). A multi-site validation trial of radioactive seed localization as an alternative to wire localization. The Breast Journal, 14(2), pp. 153-7. doi:10.1111/j.1524-4741.2007.00546.x.
Hughes JH, et al. A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization. Breast J. 2008;14(2):153-7. PubMed PMID: 18248562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A multi-site validation trial of radioactive seed localization as an alternative to wire localization. AU - Hughes,Jenevieve H, AU - Mason,Mark C, AU - Gray,Richard J, AU - McLaughlin,Sarah A, AU - Degnim,Amy C, AU - Fulmer,Jack T, AU - Pockaj,Barbara A, AU - Karstaedt,Patricia J, AU - Roarke,Michael C, Y1 - 2008/01/31/ PY - 2008/2/6/pubmed PY - 2008/4/9/medline PY - 2008/2/6/entrez SP - 153 EP - 7 JF - The breast journal JO - Breast J VL - 14 IS - 2 N2 - This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated with RSL. Margins were considered "negative" if > or =2 mm from in-situ and invasive disease. Pain and convenience scores were recorded on a 10-point scale. Patient characteristics and histology were similar. The lesion and localization device were retrieved in all patients. Margins of the first specimen were negative in 73% of RSL patients, versus 54% of WL patients (p < 0.001). A second operation was required in 8% of RSL patients to achieve negative margins, versus 25% of WL patients (p < 0.001). Pain scores were not statistically different. However, the RSL group had higher convenience scores (p = 0.015). RSL is safe, effective, and compared to WL, reduces the rates of intraoperative re-excision and reoperation for positive margins by 68%. Patient satisfaction is improved with RSL. We strongly favor RSL over WL. SN - 1524-4741 UR - https://www.unboundmedicine.com/medline/citation/18248562/A_multi_site_validation_trial_of_radioactive_seed_localization_as_an_alternative_to_wire_localization_ L2 - https://doi.org/10.1111/j.1524-4741.2007.00546.x DB - PRIME DP - Unbound Medicine ER -