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Significant correlation of glycated albumin, but not glycated haemoglobin, with arterial stiffening in haemodialysis patients with type 2 diabetes.
Clin Endocrinol (Oxf). 2008 Oct; 69(4):556-61.CE

Abstract

OBJECTIVE

We recently reported that glycated albumin (GA) is a better indicator of glycaemic control compared with glycated haemoglobin (HbA1c) in haemodialysis (HD) patients with type 2 diabetes. As poor glycaemic control is considered an independent risk factor for atherosclerosis in diabetes, the relationship between GA, HbA1c and arterial stiffening was examined in HD patients with type 2 diabetes.

PATIENTS AND METHODS

The present study comprised 134 HD patients with type 2 diabetes, and 158 patients without diabetes. Brachial-ankle pulse wave velocity (baPWV) was measured in all patients using a waveform analyser.

RESULTS

The mean plasma glucose (PG), GA and HbA1c levels were 7.49 +/- 2.28 mmol/l, 20.8 +/- 5.57% and 5.62 +/- 1.26%, respectively, in HD patients with diabetes (n = 134), which were significantly greater than the respective values of 5.77 +/- 1.89 mmol/l, 15.6 +/- 2.34% and 4.98 +/- 0.80% in those without diabetes (n = 158) (P < 0.0001). BaPWV was 21.69 +/- 6.90 m/s in HD patients with diabetes, which was significantly greater than the value of 18.74 +/- 4.89 m/s in those without diabetes (P < 0.0001). When the analysis was performed in a combined population of those patients with and without diabetes, the mean PG (r = 0.155, P < 0.05) and GA (r = 0.117, P < 0.05), but not HbA1c (r = 0.092, P = 0.125), exhibited significant correlations with baPWV. Multivariate regression analysis, which included age, gender, mean blood pressure, and serum levels of albumin, creatinine and LDL cholesterol, to evaluate the independent association of each marker for glycaemic control with baPWV values in HD patients demonstrated that GA, but not HbA1c or PG, was an independent factor that was significantly associated in a positive manner with baPWV in HD patients.

CONCLUSION

It was suggested that poor glycaemic control, as reflected by increased GA values, might be associated with increased arterial stiffening in HD patients.

Authors+Show Affiliations

Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18248645

Citation

Kumeda, Yasuro, et al. "Significant Correlation of Glycated Albumin, but Not Glycated Haemoglobin, With Arterial Stiffening in Haemodialysis Patients With Type 2 Diabetes." Clinical Endocrinology, vol. 69, no. 4, 2008, pp. 556-61.
Kumeda Y, Inaba M, Shoji S, et al. Significant correlation of glycated albumin, but not glycated haemoglobin, with arterial stiffening in haemodialysis patients with type 2 diabetes. Clin Endocrinol (Oxf). 2008;69(4):556-61.
Kumeda, Y., Inaba, M., Shoji, S., Ishimura, E., Inariba, H., Yabe, S., Okamura, M., & Nishizawa, Y. (2008). Significant correlation of glycated albumin, but not glycated haemoglobin, with arterial stiffening in haemodialysis patients with type 2 diabetes. Clinical Endocrinology, 69(4), 556-61. https://doi.org/10.1111/j.1365-2265.2008.03202.x
Kumeda Y, et al. Significant Correlation of Glycated Albumin, but Not Glycated Haemoglobin, With Arterial Stiffening in Haemodialysis Patients With Type 2 Diabetes. Clin Endocrinol (Oxf). 2008;69(4):556-61. PubMed PMID: 18248645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significant correlation of glycated albumin, but not glycated haemoglobin, with arterial stiffening in haemodialysis patients with type 2 diabetes. AU - Kumeda,Yasuro, AU - Inaba,Masaaki, AU - Shoji,Shigeichi, AU - Ishimura,Eiji, AU - Inariba,Hiromi, AU - Yabe,Sachiko, AU - Okamura,Mikio, AU - Nishizawa,Yoshiki, Y1 - 2008/01/31/ PY - 2008/2/6/pubmed PY - 2009/8/14/medline PY - 2008/2/6/entrez SP - 556 EP - 61 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 69 IS - 4 N2 - OBJECTIVE: We recently reported that glycated albumin (GA) is a better indicator of glycaemic control compared with glycated haemoglobin (HbA1c) in haemodialysis (HD) patients with type 2 diabetes. As poor glycaemic control is considered an independent risk factor for atherosclerosis in diabetes, the relationship between GA, HbA1c and arterial stiffening was examined in HD patients with type 2 diabetes. PATIENTS AND METHODS: The present study comprised 134 HD patients with type 2 diabetes, and 158 patients without diabetes. Brachial-ankle pulse wave velocity (baPWV) was measured in all patients using a waveform analyser. RESULTS: The mean plasma glucose (PG), GA and HbA1c levels were 7.49 +/- 2.28 mmol/l, 20.8 +/- 5.57% and 5.62 +/- 1.26%, respectively, in HD patients with diabetes (n = 134), which were significantly greater than the respective values of 5.77 +/- 1.89 mmol/l, 15.6 +/- 2.34% and 4.98 +/- 0.80% in those without diabetes (n = 158) (P < 0.0001). BaPWV was 21.69 +/- 6.90 m/s in HD patients with diabetes, which was significantly greater than the value of 18.74 +/- 4.89 m/s in those without diabetes (P < 0.0001). When the analysis was performed in a combined population of those patients with and without diabetes, the mean PG (r = 0.155, P < 0.05) and GA (r = 0.117, P < 0.05), but not HbA1c (r = 0.092, P = 0.125), exhibited significant correlations with baPWV. Multivariate regression analysis, which included age, gender, mean blood pressure, and serum levels of albumin, creatinine and LDL cholesterol, to evaluate the independent association of each marker for glycaemic control with baPWV values in HD patients demonstrated that GA, but not HbA1c or PG, was an independent factor that was significantly associated in a positive manner with baPWV in HD patients. CONCLUSION: It was suggested that poor glycaemic control, as reflected by increased GA values, might be associated with increased arterial stiffening in HD patients. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/18248645/Significant_correlation_of_glycated_albumin_but_not_glycated_haemoglobin_with_arterial_stiffening_in_haemodialysis_patients_with_type_2_diabetes_ L2 - https://doi.org/10.1111/j.1365-2265.2008.03202.x DB - PRIME DP - Unbound Medicine ER -