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Diagnostic criteria for metabolic syndrome: a comparative analysis in an unselected sample of adult male population.
Metabolism. 2008 Mar; 57(3):355-61.M

Abstract

This analysis compares the performance of 7 different diagnostic criteria of metabolic syndrome (MS) with regard to the prevalence of the syndrome, the characteristics of subjects with a positive diagnosis, and the ability to correctly identify individuals at high calculated cardiovascular (CV) risk or with signs of systemic inflammation or early organ damage. The diagnostic criteria proposed by the World Health Organization (1998); European Group for the Study of Insulin Resistance (EGIR) (1999); Adult Treatment Panel III (ATP III) (2001); American Association of Clinical Endocrinologists (AACE) (2003); ATP III (2004); International Diabetes Federation (IDF) (2005); and American Heart Association/National Heart, Lung, and Blood Institute (2005) were applied to the population of 933 men aged 59.5 years (range, 33-81 years) attending the 2002-2004 examination of the Olivetti Heart Study. Standardized measurements were available for body mass index, waist circumference, blood pressure, fasting serum total and high-density lipoprotein cholesterol, triglyceride, glucose, insulin, high-sensitivity C-reactive protein, and microalbuminuria. Insulin resistance was estimated by the homeostasis model assessment index; and CV risk, by the Prospective Cardiovascular Munster algorithm. The MS prevalence ranged from 8.6% (AACE) to 44.5% (IDF). Among MS-positive subjects, insulin resistance ranged from 94.8% (EGIR) to 49.2% (IDF), whereas type 2 diabetes mellitus (excluded by EGIR and AACE criteria) rated 59.9% by World Health Organization and 22% to 24% by ATP III, IDF, or American Heart Association/National Heart, Lung, and Blood Institute. By most criteria, MS-positive subjects had greater calculated CV risk than MS-negative subjects; but in general, the ability to correctly identify individuals at high CV risk was dampened by limited sensitivity (maximum 60%). Lowering the cutoff for abdominal adiposity (waist circumference <94 cm by IDF) did not improve the performance in this regard but identified a larger number of individuals with microalbuminuria (56%) and elevated C-reactive protein (53%).

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, "Federico II" University of Naples, 80131 Naples, Italy. strazzul@unima.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18249207

Citation

Strazzullo, Pasquale, et al. "Diagnostic Criteria for Metabolic Syndrome: a Comparative Analysis in an Unselected Sample of Adult Male Population." Metabolism: Clinical and Experimental, vol. 57, no. 3, 2008, pp. 355-61.
Strazzullo P, Barbato A, Siani A, et al. Diagnostic criteria for metabolic syndrome: a comparative analysis in an unselected sample of adult male population. Metab Clin Exp. 2008;57(3):355-61.
Strazzullo, P., Barbato, A., Siani, A., Cappuccio, F. P., Versiero, M., Schiattarella, P., Russo, O., Avallone, S., della Valle, E., & Farinaro, E. (2008). Diagnostic criteria for metabolic syndrome: a comparative analysis in an unselected sample of adult male population. Metabolism: Clinical and Experimental, 57(3), 355-61. https://doi.org/10.1016/j.metabol.2007.10.010
Strazzullo P, et al. Diagnostic Criteria for Metabolic Syndrome: a Comparative Analysis in an Unselected Sample of Adult Male Population. Metab Clin Exp. 2008;57(3):355-61. PubMed PMID: 18249207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic criteria for metabolic syndrome: a comparative analysis in an unselected sample of adult male population. AU - Strazzullo,Pasquale, AU - Barbato,Antonio, AU - Siani,Alfonso, AU - Cappuccio,Francesco P, AU - Versiero,Marco, AU - Schiattarella,Pierluigi, AU - Russo,Ornella, AU - Avallone,Sonia, AU - della Valle,Elisabetta, AU - Farinaro,Eduardo, PY - 2007/04/10/received PY - 2007/10/16/accepted PY - 2008/2/6/pubmed PY - 2008/3/12/medline PY - 2008/2/6/entrez SP - 355 EP - 61 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 57 IS - 3 N2 - This analysis compares the performance of 7 different diagnostic criteria of metabolic syndrome (MS) with regard to the prevalence of the syndrome, the characteristics of subjects with a positive diagnosis, and the ability to correctly identify individuals at high calculated cardiovascular (CV) risk or with signs of systemic inflammation or early organ damage. The diagnostic criteria proposed by the World Health Organization (1998); European Group for the Study of Insulin Resistance (EGIR) (1999); Adult Treatment Panel III (ATP III) (2001); American Association of Clinical Endocrinologists (AACE) (2003); ATP III (2004); International Diabetes Federation (IDF) (2005); and American Heart Association/National Heart, Lung, and Blood Institute (2005) were applied to the population of 933 men aged 59.5 years (range, 33-81 years) attending the 2002-2004 examination of the Olivetti Heart Study. Standardized measurements were available for body mass index, waist circumference, blood pressure, fasting serum total and high-density lipoprotein cholesterol, triglyceride, glucose, insulin, high-sensitivity C-reactive protein, and microalbuminuria. Insulin resistance was estimated by the homeostasis model assessment index; and CV risk, by the Prospective Cardiovascular Munster algorithm. The MS prevalence ranged from 8.6% (AACE) to 44.5% (IDF). Among MS-positive subjects, insulin resistance ranged from 94.8% (EGIR) to 49.2% (IDF), whereas type 2 diabetes mellitus (excluded by EGIR and AACE criteria) rated 59.9% by World Health Organization and 22% to 24% by ATP III, IDF, or American Heart Association/National Heart, Lung, and Blood Institute. By most criteria, MS-positive subjects had greater calculated CV risk than MS-negative subjects; but in general, the ability to correctly identify individuals at high CV risk was dampened by limited sensitivity (maximum 60%). Lowering the cutoff for abdominal adiposity (waist circumference <94 cm by IDF) did not improve the performance in this regard but identified a larger number of individuals with microalbuminuria (56%) and elevated C-reactive protein (53%). SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/18249207/Diagnostic_criteria_for_metabolic_syndrome:_a_comparative_analysis_in_an_unselected_sample_of_adult_male_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(07)00370-8 DB - PRIME DP - Unbound Medicine ER -