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Differential effect of atorvastatin and fenofibrate on plasma oxidized low-density lipoprotein, inflammation markers, and cell adhesion molecules in patients with type 2 diabetes mellitus.
Metabolism 2008; 57(3):380-6M

Abstract

Type 2 diabetes mellitus is associated with elevated plasma triglyceride levels, low high-density lipoprotein cholesterol, and a high incidence of cardiovascular disease. Hydroxymethylglutaryl-coenzyme A reductase inhibitors and fibrates are frequently used in the treatment of diabetic dyslipidemia, but their specific impact on the inflammation processes involved in atherosclerosis remains to be fully characterized. The objective of this 2-group parallel study was to investigate the differential effects of a 6-week treatment with either atorvastatin 20 mg/d alone (n = 19) or micronized fenofibrate 200 mg/d alone (n = 19) on inflammation, cell adhesion, and oxidation markers in type 2 diabetes mellitus subjects with marked hypertriglyceridemia. In addition to the expected changes in lipid levels, atorvastatin decreased plasma levels of C-reactive protein (-26.9%, P = .004), soluble intercellular adhesion molecule 1 (-5.4%, P = .03), soluble vascular cell adhesion molecule 1 (-4.4%, P = .008), sE-selectin (-5.7%, P = .02), matrix metalloproteinase 9 (-39.6%, P = .04), secretory phospholipase A(2) (sPLA(2)) (-14.8%, P = .04), and oxidized low-density lipoprotein (-38.4%, P < .0001). On the other hand, fenofibrate had no significant effect on C-reactive protein levels and was associated with reduced plasma levels of sE-selectin only (-6.0%, P = .04) and increased plasma levels of sPLA(2) (+22.5%, P = .004). These results suggest that atorvastatin was potent to reduce inflammation, oxidation, and monocyte adhesion in type 2 diabetes mellitus subjects with marked hypertriglyceridemia, whereas fenofibrate decreased sE-selectin levels only and was associated with an elevation of sPLA(2) levels.

Authors+Show Affiliations

Lipid Research Center, Laval University Medical Center, Quebec City, Canada G1V 4G2.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18249211

Citation

Hogue, Jean-Charles, et al. "Differential Effect of Atorvastatin and Fenofibrate On Plasma Oxidized Low-density Lipoprotein, Inflammation Markers, and Cell Adhesion Molecules in Patients With Type 2 Diabetes Mellitus." Metabolism: Clinical and Experimental, vol. 57, no. 3, 2008, pp. 380-6.
Hogue JC, Lamarche B, Tremblay AJ, et al. Differential effect of atorvastatin and fenofibrate on plasma oxidized low-density lipoprotein, inflammation markers, and cell adhesion molecules in patients with type 2 diabetes mellitus. Metab Clin Exp. 2008;57(3):380-6.
Hogue, J. C., Lamarche, B., Tremblay, A. J., Bergeron, J., Gagné, C., & Couture, P. (2008). Differential effect of atorvastatin and fenofibrate on plasma oxidized low-density lipoprotein, inflammation markers, and cell adhesion molecules in patients with type 2 diabetes mellitus. Metabolism: Clinical and Experimental, 57(3), pp. 380-6. doi:10.1016/j.metabol.2007.10.014.
Hogue JC, et al. Differential Effect of Atorvastatin and Fenofibrate On Plasma Oxidized Low-density Lipoprotein, Inflammation Markers, and Cell Adhesion Molecules in Patients With Type 2 Diabetes Mellitus. Metab Clin Exp. 2008;57(3):380-6. PubMed PMID: 18249211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effect of atorvastatin and fenofibrate on plasma oxidized low-density lipoprotein, inflammation markers, and cell adhesion molecules in patients with type 2 diabetes mellitus. AU - Hogue,Jean-Charles, AU - Lamarche,Benoît, AU - Tremblay,André J, AU - Bergeron,Jean, AU - Gagné,Claude, AU - Couture,Patrick, PY - 2007/05/11/received PY - 2007/10/16/accepted PY - 2008/2/6/pubmed PY - 2008/3/12/medline PY - 2008/2/6/entrez SP - 380 EP - 6 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 57 IS - 3 N2 - Type 2 diabetes mellitus is associated with elevated plasma triglyceride levels, low high-density lipoprotein cholesterol, and a high incidence of cardiovascular disease. Hydroxymethylglutaryl-coenzyme A reductase inhibitors and fibrates are frequently used in the treatment of diabetic dyslipidemia, but their specific impact on the inflammation processes involved in atherosclerosis remains to be fully characterized. The objective of this 2-group parallel study was to investigate the differential effects of a 6-week treatment with either atorvastatin 20 mg/d alone (n = 19) or micronized fenofibrate 200 mg/d alone (n = 19) on inflammation, cell adhesion, and oxidation markers in type 2 diabetes mellitus subjects with marked hypertriglyceridemia. In addition to the expected changes in lipid levels, atorvastatin decreased plasma levels of C-reactive protein (-26.9%, P = .004), soluble intercellular adhesion molecule 1 (-5.4%, P = .03), soluble vascular cell adhesion molecule 1 (-4.4%, P = .008), sE-selectin (-5.7%, P = .02), matrix metalloproteinase 9 (-39.6%, P = .04), secretory phospholipase A(2) (sPLA(2)) (-14.8%, P = .04), and oxidized low-density lipoprotein (-38.4%, P < .0001). On the other hand, fenofibrate had no significant effect on C-reactive protein levels and was associated with reduced plasma levels of sE-selectin only (-6.0%, P = .04) and increased plasma levels of sPLA(2) (+22.5%, P = .004). These results suggest that atorvastatin was potent to reduce inflammation, oxidation, and monocyte adhesion in type 2 diabetes mellitus subjects with marked hypertriglyceridemia, whereas fenofibrate decreased sE-selectin levels only and was associated with an elevation of sPLA(2) levels. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/18249211/Differential_effect_of_atorvastatin_and_fenofibrate_on_plasma_oxidized_low_density_lipoprotein_inflammation_markers_and_cell_adhesion_molecules_in_patients_with_type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(07)00374-5 DB - PRIME DP - Unbound Medicine ER -