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Follicular fluid anti-Müllerian hormone and inhibin B concentrations: comparison between gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist cycles.
Fertil Steril. 2008 Apr; 89(4):860-7.FS

Abstract

OBJECTIVE

To compare follicular fluid (FF) anti-Müllerian hormone (AMH) and inhibin B concentrations for GnRH agonist (GnRH-a) and GnRH antagonist cycles and to determine the correlations between FF AMH or inhibin B concentrations and controlled ovarian hyperstimulation (COH) outcomes.

DESIGN

Prospective comparative study.

SETTING

University hospital.

PATIENT(S)

Eighty-seven women who underwent COH cycles, either in the GnRH-a long-protocol group (n = 43) or the GnRH antagonist multiple-dose flexible-protocol group (n = 44).

INTERVENTION(S)

Follicular fluid was obtained from dominant follicles during oocyte retrieval, and FF AMH, inhibin B, E(2), and P concentrations were measured. Serum levels of AMH and inhibin B also were assessed on the day of oocyte retrieval.

MAIN OUTCOME MEASURE(S)

Follicular fluid AMH and inhibin B concentrations.

RESULT(S)

Concentrations of serum AMH and inhibin B and of FF AMH, inhibin B, E(2), and P were similar in the two groups. Follicular fluid AMH levels were found to be significantly correlated with age, gonadotropin dose, number of follicles on hCG day, and number of oocytes retrieved.

CONCLUSION(S)

Our results suggest that there is no significant difference in follicular microenvironment in terms of AMH and inhibin B secretion between GnRH-a and GnRH antagonist protocols and that FF AMH is a marker that reflects ovarian reserve and response to COH.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18249372

Citation

Lee, Jung Ryeol, et al. "Follicular Fluid anti-Müllerian Hormone and Inhibin B Concentrations: Comparison Between Gonadotropin-releasing Hormone (GnRH) Agonist and GnRH Antagonist Cycles." Fertility and Sterility, vol. 89, no. 4, 2008, pp. 860-7.
Lee JR, Kim SH, Kim SM, et al. Follicular fluid anti-Müllerian hormone and inhibin B concentrations: comparison between gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist cycles. Fertil Steril. 2008;89(4):860-7.
Lee, J. R., Kim, S. H., Kim, S. M., Jee, B. C., Ku, S. Y., Suh, C. S., Choi, Y. M., Kim, J. G., & Moon, S. Y. (2008). Follicular fluid anti-Müllerian hormone and inhibin B concentrations: comparison between gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist cycles. Fertility and Sterility, 89(4), 860-7. https://doi.org/10.1016/j.fertnstert.2007.04.010
Lee JR, et al. Follicular Fluid anti-Müllerian Hormone and Inhibin B Concentrations: Comparison Between Gonadotropin-releasing Hormone (GnRH) Agonist and GnRH Antagonist Cycles. Fertil Steril. 2008;89(4):860-7. PubMed PMID: 18249372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Follicular fluid anti-Müllerian hormone and inhibin B concentrations: comparison between gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist cycles. AU - Lee,Jung Ryeol, AU - Kim,Seok Hyun, AU - Kim,Sun Mie, AU - Jee,Byung Chul, AU - Ku,Seung-Yup, AU - Suh,Chang Suk, AU - Choi,Young Min, AU - Kim,Jung Gu, AU - Moon,Shin Yong, Y1 - 2008/02/04/ PY - 2007/02/16/received PY - 2007/04/10/revised PY - 2007/04/10/accepted PY - 2008/2/6/pubmed PY - 2008/4/30/medline PY - 2008/2/6/entrez SP - 860 EP - 7 JF - Fertility and sterility JO - Fertil Steril VL - 89 IS - 4 N2 - OBJECTIVE: To compare follicular fluid (FF) anti-Müllerian hormone (AMH) and inhibin B concentrations for GnRH agonist (GnRH-a) and GnRH antagonist cycles and to determine the correlations between FF AMH or inhibin B concentrations and controlled ovarian hyperstimulation (COH) outcomes. DESIGN: Prospective comparative study. SETTING: University hospital. PATIENT(S): Eighty-seven women who underwent COH cycles, either in the GnRH-a long-protocol group (n = 43) or the GnRH antagonist multiple-dose flexible-protocol group (n = 44). INTERVENTION(S): Follicular fluid was obtained from dominant follicles during oocyte retrieval, and FF AMH, inhibin B, E(2), and P concentrations were measured. Serum levels of AMH and inhibin B also were assessed on the day of oocyte retrieval. MAIN OUTCOME MEASURE(S): Follicular fluid AMH and inhibin B concentrations. RESULT(S): Concentrations of serum AMH and inhibin B and of FF AMH, inhibin B, E(2), and P were similar in the two groups. Follicular fluid AMH levels were found to be significantly correlated with age, gonadotropin dose, number of follicles on hCG day, and number of oocytes retrieved. CONCLUSION(S): Our results suggest that there is no significant difference in follicular microenvironment in terms of AMH and inhibin B secretion between GnRH-a and GnRH antagonist protocols and that FF AMH is a marker that reflects ovarian reserve and response to COH. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18249372/Follicular_fluid_anti_Müllerian_hormone_and_inhibin_B_concentrations:_comparison_between_gonadotropin_releasing_hormone__GnRH__agonist_and_GnRH_antagonist_cycles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)00966-1 DB - PRIME DP - Unbound Medicine ER -