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Effects of hormone therapy and tibolone on body composition and serum leptin levels in postmenopausal women.
Fertil Steril. 2009 Feb; 91(2):425-31.FS

Abstract

OBJECTIVE

To compare the changes in body composition and in leptin levels in postmenopausal women receiving hormone therapy (HT) or tibolone.

DESIGN

Prospective comparative study.

SETTING

Menopause Unit in a tertiary Hospital.

PATIENT(S)

One hundred twenty women were recruited.

INTERVENTION(S)

Women were assigned into a control group, HT, and tibolone group.

MAIN OUTCOME MEASURE(S)

Anthropometric indices, leptin levels, tissue fat percentage, total fat, and lean mass measurements were performed at baseline and after 6 months.

RESULT(S)

The serum leptin levels were in strong correlation with the total fat percentage and total fat mass at baseline. Untreated women had weight gain and a gradual decrease in leptin levels. Women receiving HT had significantly increased leptin levels. Women in the tibolone group, however, had a significant decrease in leptin levels accompanied by decreased total fat mass, fat percentage, and increased total lean mass. The changes in leptin levels were more pronounced in lean women.

CONCLUSION(S)

Postmenopausal women tend to gain weight accompanied with a reduction in leptin concentrations. Hormone therapy administration increases leptin levels while maintaining body weight and body fat distribution, whereas tibolone use decreases leptin levels, total fat percentage, and total fat mass.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Umraniye State Hospital, Istanbul, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18249383

Citation

Dedeoğlu, Emine Nihan, et al. "Effects of Hormone Therapy and Tibolone On Body Composition and Serum Leptin Levels in Postmenopausal Women." Fertility and Sterility, vol. 91, no. 2, 2009, pp. 425-31.
Dedeoğlu EN, Erenus M, Yörük P. Effects of hormone therapy and tibolone on body composition and serum leptin levels in postmenopausal women. Fertil Steril. 2009;91(2):425-31.
Dedeoğlu, E. N., Erenus, M., & Yörük, P. (2009). Effects of hormone therapy and tibolone on body composition and serum leptin levels in postmenopausal women. Fertility and Sterility, 91(2), 425-31. https://doi.org/10.1016/j.fertnstert.2007.11.061
Dedeoğlu EN, Erenus M, Yörük P. Effects of Hormone Therapy and Tibolone On Body Composition and Serum Leptin Levels in Postmenopausal Women. Fertil Steril. 2009;91(2):425-31. PubMed PMID: 18249383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of hormone therapy and tibolone on body composition and serum leptin levels in postmenopausal women. AU - Dedeoğlu,Emine Nihan, AU - Erenus,Mithat, AU - Yörük,Pinar, Y1 - 2008/02/04/ PY - 2007/09/22/received PY - 2007/11/19/revised PY - 2007/11/19/accepted PY - 2008/2/6/pubmed PY - 2009/2/21/medline PY - 2008/2/6/entrez SP - 425 EP - 31 JF - Fertility and sterility JO - Fertil Steril VL - 91 IS - 2 N2 - OBJECTIVE: To compare the changes in body composition and in leptin levels in postmenopausal women receiving hormone therapy (HT) or tibolone. DESIGN: Prospective comparative study. SETTING: Menopause Unit in a tertiary Hospital. PATIENT(S): One hundred twenty women were recruited. INTERVENTION(S): Women were assigned into a control group, HT, and tibolone group. MAIN OUTCOME MEASURE(S): Anthropometric indices, leptin levels, tissue fat percentage, total fat, and lean mass measurements were performed at baseline and after 6 months. RESULT(S): The serum leptin levels were in strong correlation with the total fat percentage and total fat mass at baseline. Untreated women had weight gain and a gradual decrease in leptin levels. Women receiving HT had significantly increased leptin levels. Women in the tibolone group, however, had a significant decrease in leptin levels accompanied by decreased total fat mass, fat percentage, and increased total lean mass. The changes in leptin levels were more pronounced in lean women. CONCLUSION(S): Postmenopausal women tend to gain weight accompanied with a reduction in leptin concentrations. Hormone therapy administration increases leptin levels while maintaining body weight and body fat distribution, whereas tibolone use decreases leptin levels, total fat percentage, and total fat mass. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18249383/Effects_of_hormone_therapy_and_tibolone_on_body_composition_and_serum_leptin_levels_in_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)04126-X DB - PRIME DP - Unbound Medicine ER -