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Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events.
Arch Gen Psychiatry 2008; 65(2):146-52AG

Abstract

CONTEXT

Most societies believe that a mother's psychological state can influence her unborn baby. Severe adverse life events during pregnancy have been consistently associated with an elevated risk of low birth weight and prematurity. Such events during the first trimester have also been associated with risk of congenital malformations.

OBJECTIVE

To assess the effect in offspring of antenatal maternal exposure to an objective measure of stress on risk of adverse neurodevelopment, specifically schizophrenia. We hypothesized that the strongest relationship would be to maternal exposures during the first trimester.

DESIGN

Population-based study.

SETTING

Denmark.

PARTICIPANTS

In a cohort of 1.38 million Danish births from 1973 to 1995, mothers were considered exposed if 1 (or more) of their close relatives died or was diagnosed with cancer, acute myocardial infarction, or stroke syndrome up to 6 months before conception or during pregnancy. Offspring were followed up from their 10th birthday until their death, migration, onset of schizophrenia, or June 30, 2005; admissions were identified by linkage to the Central Psychiatric Register. Main Outcome Measure Schizophrenia.

RESULTS

The risk of schizophrenia and related disorders was raised in offspring whose mothers were exposed to death of a relative during the first trimester (adjusted relative risk, 1.67 [95% confidence interval, 1.02-2.73]). Death of a relative during other trimesters or up to 6 months before pregnancy were not linked with a higher risk of schizophrenia.

CONCLUSIONS

Our population-based study suggests that severe stress to a mother during the first trimester may alter the risk of schizophrenia in offspring. This finding is consistent with ecological evidence from whole populations exposed to severe stressors and suggests that environment may influence neurodevelopment at the feto-placental-maternal interface.

Authors+Show Affiliations

Centre for Women's Mental Health Research, University of Manchester, Manchester M13 9PL, England.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18250252

Citation

Khashan, Ali S., et al. "Higher Risk of Offspring Schizophrenia Following Antenatal Maternal Exposure to Severe Adverse Life Events." Archives of General Psychiatry, vol. 65, no. 2, 2008, pp. 146-52.
Khashan AS, Abel KM, McNamee R, et al. Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events. Arch Gen Psychiatry. 2008;65(2):146-52.
Khashan, A. S., Abel, K. M., McNamee, R., Pedersen, M. G., Webb, R. T., Baker, P. N., ... Mortensen, P. B. (2008). Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events. Archives of General Psychiatry, 65(2), pp. 146-52. doi:10.1001/archgenpsychiatry.2007.20.
Khashan AS, et al. Higher Risk of Offspring Schizophrenia Following Antenatal Maternal Exposure to Severe Adverse Life Events. Arch Gen Psychiatry. 2008;65(2):146-52. PubMed PMID: 18250252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events. AU - Khashan,Ali S, AU - Abel,Kathryn M, AU - McNamee,Roseanne, AU - Pedersen,Marianne G, AU - Webb,Roger T, AU - Baker,Philip N, AU - Kenny,Louise C, AU - Mortensen,Preben Bo, PY - 2008/2/6/pubmed PY - 2008/2/22/medline PY - 2008/2/6/entrez SP - 146 EP - 52 JF - Archives of general psychiatry JO - Arch. Gen. Psychiatry VL - 65 IS - 2 N2 - CONTEXT: Most societies believe that a mother's psychological state can influence her unborn baby. Severe adverse life events during pregnancy have been consistently associated with an elevated risk of low birth weight and prematurity. Such events during the first trimester have also been associated with risk of congenital malformations. OBJECTIVE: To assess the effect in offspring of antenatal maternal exposure to an objective measure of stress on risk of adverse neurodevelopment, specifically schizophrenia. We hypothesized that the strongest relationship would be to maternal exposures during the first trimester. DESIGN: Population-based study. SETTING: Denmark. PARTICIPANTS: In a cohort of 1.38 million Danish births from 1973 to 1995, mothers were considered exposed if 1 (or more) of their close relatives died or was diagnosed with cancer, acute myocardial infarction, or stroke syndrome up to 6 months before conception or during pregnancy. Offspring were followed up from their 10th birthday until their death, migration, onset of schizophrenia, or June 30, 2005; admissions were identified by linkage to the Central Psychiatric Register. Main Outcome Measure Schizophrenia. RESULTS: The risk of schizophrenia and related disorders was raised in offspring whose mothers were exposed to death of a relative during the first trimester (adjusted relative risk, 1.67 [95% confidence interval, 1.02-2.73]). Death of a relative during other trimesters or up to 6 months before pregnancy were not linked with a higher risk of schizophrenia. CONCLUSIONS: Our population-based study suggests that severe stress to a mother during the first trimester may alter the risk of schizophrenia in offspring. This finding is consistent with ecological evidence from whole populations exposed to severe stressors and suggests that environment may influence neurodevelopment at the feto-placental-maternal interface. SN - 1538-3636 UR - https://www.unboundmedicine.com/medline/citation/18250252/Higher_risk_of_offspring_schizophrenia_following_antenatal_maternal_exposure_to_severe_adverse_life_events_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=18250252.ui DB - PRIME DP - Unbound Medicine ER -