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Bleeding index after the first course of endoscopic treatment for esophageal varices in liver cirrhotic patients with and without hepatocellular carcinoma.
Hepatogastroenterology. 2007 Oct-Nov; 54(79):2049-54.H

Abstract

BACKGROUND/AIMS

We retrospectively evaluated variable clinical data on admission to reliably predict bleeding from esophageal varices after the first course of endoscopic treatment in liver cirrhosis patients with and without hepatocellular carcinoma.

METHODOLOGY

We analyzed 27 clinical factors from the medical records of 118 patients who received their first course of endoscopic treatment for esophageal varices. Factors significantly related to bleeding were extracted using Cox's regression model, and the bleeding index was prepared by combining these factors.

RESULTS

The cumulative nonbleeding rates after treatment for esophageal varices were 82.1% at 1 year, 64.6% at 3 years and 53.7% at 5 years. By the multivariate analysis, age, the presence of hepatocellular carcinoma, hemoglobin, lactate dehydrogenase and alpha-fetoprotein were selected as significant factors that contributed independently to the post-therapeutic bleeding from esophageal varices (P<0.05). The bleeding index was calculated using the following formula: bleeding index = - 0.045 x Age + 0.934 x hepatocellular carcinoma - 0.151 x hemoglobin + 0.108 x lactate dehydrogenase + 0.842 x alpha-fetoprotein.

CONCLUSIONS

The bleeding index, based on 5 factors, will in future be an appropriate index to predict the post-therapeutic bleeding from esophageal varices.

Authors+Show Affiliations

Department of Pathophysiology, Showa University School of Pharmaceutical Sciences, Shinagawa-ku, Tokyo 142-8555, Japan. mari-k@pharm.showa-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18251158

Citation

Kogo, Mari, et al. "Bleeding Index After the First Course of Endoscopic Treatment for Esophageal Varices in Liver Cirrhotic Patients With and Without Hepatocellular Carcinoma." Hepato-gastroenterology, vol. 54, no. 79, 2007, pp. 2049-54.
Kogo M, Sato N, Yoneyama K, et al. Bleeding index after the first course of endoscopic treatment for esophageal varices in liver cirrhotic patients with and without hepatocellular carcinoma. Hepatogastroenterology. 2007;54(79):2049-54.
Kogo, M., Sato, N., Yoneyama, K., Imawari, M., & Kiuchi, Y. (2007). Bleeding index after the first course of endoscopic treatment for esophageal varices in liver cirrhotic patients with and without hepatocellular carcinoma. Hepato-gastroenterology, 54(79), 2049-54.
Kogo M, et al. Bleeding Index After the First Course of Endoscopic Treatment for Esophageal Varices in Liver Cirrhotic Patients With and Without Hepatocellular Carcinoma. Hepatogastroenterology. 2007 Oct-Nov;54(79):2049-54. PubMed PMID: 18251158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bleeding index after the first course of endoscopic treatment for esophageal varices in liver cirrhotic patients with and without hepatocellular carcinoma. AU - Kogo,Mari, AU - Sato,Naka, AU - Yoneyama,Keiichiro, AU - Imawari,Michio, AU - Kiuchi,Yuji, PY - 2008/2/7/pubmed PY - 2008/3/15/medline PY - 2008/2/7/entrez SP - 2049 EP - 54 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 54 IS - 79 N2 - BACKGROUND/AIMS: We retrospectively evaluated variable clinical data on admission to reliably predict bleeding from esophageal varices after the first course of endoscopic treatment in liver cirrhosis patients with and without hepatocellular carcinoma. METHODOLOGY: We analyzed 27 clinical factors from the medical records of 118 patients who received their first course of endoscopic treatment for esophageal varices. Factors significantly related to bleeding were extracted using Cox's regression model, and the bleeding index was prepared by combining these factors. RESULTS: The cumulative nonbleeding rates after treatment for esophageal varices were 82.1% at 1 year, 64.6% at 3 years and 53.7% at 5 years. By the multivariate analysis, age, the presence of hepatocellular carcinoma, hemoglobin, lactate dehydrogenase and alpha-fetoprotein were selected as significant factors that contributed independently to the post-therapeutic bleeding from esophageal varices (P<0.05). The bleeding index was calculated using the following formula: bleeding index = - 0.045 x Age + 0.934 x hepatocellular carcinoma - 0.151 x hemoglobin + 0.108 x lactate dehydrogenase + 0.842 x alpha-fetoprotein. CONCLUSIONS: The bleeding index, based on 5 factors, will in future be an appropriate index to predict the post-therapeutic bleeding from esophageal varices. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/18251158/Bleeding_index_after_the_first_course_of_endoscopic_treatment_for_esophageal_varices_in_liver_cirrhotic_patients_with_and_without_hepatocellular_carcinoma_ L2 - http://www.diseaseinfosearch.org/result/2658 DB - PRIME DP - Unbound Medicine ER -