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Changes in folate, vitamin B12 and homocysteine associated with incident dementia.
J Neurol Neurosurg Psychiatry. 2008 Aug; 79(8):864-8.JN

Abstract

OBJECTIVES

Prospective findings have not been consistent for folate, vitamin B(12) and homocysteine concentrations as predictors of dementia. This study aimed to investigate both baseline concentrations of folate, vitamin B(12) and homocysteine and changes in these concentrations as predictors/correlates of incident dementia.

METHODS

Of 625 elderly patients without dementia at baseline, 518 (83%) were followed over a 2.4 year period and were clinically assessed for incident dementia and Alzheimer's disease (AD). Serum concentrations of folate, vitamin B(12) and homocysteine were measured at the baseline and follow-up assessments. Covariates included age, sex, education, disability, depression, alcohol consumption, physical activity, vascular risk factors, serum creatinine concentration, vitamin intake and weight change.

RESULTS

Only baseline lower folate concentrations predicted incident dementia. The onset of dementia was significantly associated with an exaggerated decline in folate, a weaker increase in vitamin B(12) concentrations and an exaggerated increase in homocysteine concentrations over the follow-up period. These associations were reduced following adjustment for weight change over the same period.

CONCLUSIONS

Incident dementia is more strongly associated with changes in folate, vitamin B(12) and homocysteine than with previous concentrations. These changes may be linked to other somatic manifestations of early dementia, such as weight loss.

Authors+Show Affiliations

Department of Psychiatry and Centre for Aging and Geriatrics, Chonnam National University Medical School, Kwangju, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18252751

Citation

Kim, J-M, et al. "Changes in Folate, Vitamin B12 and Homocysteine Associated With Incident Dementia." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 79, no. 8, 2008, pp. 864-8.
Kim JM, Stewart R, Kim SW, et al. Changes in folate, vitamin B12 and homocysteine associated with incident dementia. J Neurol Neurosurg Psychiatry. 2008;79(8):864-8.
Kim, J. M., Stewart, R., Kim, S. W., Shin, I. S., Yang, S. J., Shin, H. Y., & Yoon, J. S. (2008). Changes in folate, vitamin B12 and homocysteine associated with incident dementia. Journal of Neurology, Neurosurgery, and Psychiatry, 79(8), 864-8. https://doi.org/10.1136/jnnp.2007.131482
Kim JM, et al. Changes in Folate, Vitamin B12 and Homocysteine Associated With Incident Dementia. J Neurol Neurosurg Psychiatry. 2008;79(8):864-8. PubMed PMID: 18252751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in folate, vitamin B12 and homocysteine associated with incident dementia. AU - Kim,J-M, AU - Stewart,R, AU - Kim,S-W, AU - Shin,I-S, AU - Yang,S-J, AU - Shin,H-Y, AU - Yoon,J-S, Y1 - 2008/02/05/ PY - 2008/2/7/pubmed PY - 2008/8/1/medline PY - 2008/2/7/entrez SP - 864 EP - 8 JF - Journal of neurology, neurosurgery, and psychiatry JO - J Neurol Neurosurg Psychiatry VL - 79 IS - 8 N2 - OBJECTIVES: Prospective findings have not been consistent for folate, vitamin B(12) and homocysteine concentrations as predictors of dementia. This study aimed to investigate both baseline concentrations of folate, vitamin B(12) and homocysteine and changes in these concentrations as predictors/correlates of incident dementia. METHODS: Of 625 elderly patients without dementia at baseline, 518 (83%) were followed over a 2.4 year period and were clinically assessed for incident dementia and Alzheimer's disease (AD). Serum concentrations of folate, vitamin B(12) and homocysteine were measured at the baseline and follow-up assessments. Covariates included age, sex, education, disability, depression, alcohol consumption, physical activity, vascular risk factors, serum creatinine concentration, vitamin intake and weight change. RESULTS: Only baseline lower folate concentrations predicted incident dementia. The onset of dementia was significantly associated with an exaggerated decline in folate, a weaker increase in vitamin B(12) concentrations and an exaggerated increase in homocysteine concentrations over the follow-up period. These associations were reduced following adjustment for weight change over the same period. CONCLUSIONS: Incident dementia is more strongly associated with changes in folate, vitamin B(12) and homocysteine than with previous concentrations. These changes may be linked to other somatic manifestations of early dementia, such as weight loss. SN - 1468-330X UR - https://www.unboundmedicine.com/medline/citation/18252751/Changes_in_folate_vitamin_B12_and_homocysteine_associated_with_incident_dementia_ L2 - https://jnnp.bmj.com/lookup/pmidlookup?view=long&pmid=18252751 DB - PRIME DP - Unbound Medicine ER -