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Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats.
Cardiovasc Res. 2008 Jun 01; 78(3):523-32.CR

Abstract

AIMS

Our aim was to test the hypothesis that angiotensin II receptor blockade combined with exercise training after myocardial infarction (MI) could attenuate post-MI left ventricular remodelling and preserve cardiac function.

METHODS AND RESULTS

Sprague-Dawley rats underwent ligation of the left descending coronary artery, resulting in MI, or a sham operation. Losartan treatment and exercise training were initiated 1 week after infarction and continued for 8 weeks, either as a single intervention or combined. Collagen volume fraction in the sedentary MI (MISed) group was significantly higher than other MI groups treated with exercise training and/or losartan. Compared with MISed group, hearts of rats receiving exercise and/or losartan treatment had lower tissue inhibitor of matrix metalloproteinase (TIMP) 1. Matrix metalloproteinase (MMP) 2 or MMP-9 did not differ among all groups. Additionally, the level of angiotensin II receptor type 1 (AT1) protein significantly decreased in response to exercise training. Furthermore, angiotensin converting enzyme (ACE) binding was markedly lower in hearts receiving exercise training than in the MISed hearts. Cardiac function was preserved in rats receiving exercise training, and the beneficial effect was further improved by exercise combined with losartan treatment in comparison to the MISed group.

CONCLUSION

Our results suggest that post-MI exercise training and/or AngII receptor blockade reduces TIMP-1 expression and mitigates the expressions of ACE and AT1 receptor. These improvements, in turn, attenuate myocardial fibrosis and preserve post-MI cardiac function.

Authors+Show Affiliations

Laboratory of Cardiovascular Research, University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX 78249, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18252761

Citation

Xu, Xiaohua, et al. "Exercise Training Combined With Angiotensin II Receptor Blockade Limits Post-infarct Ventricular Remodelling in Rats." Cardiovascular Research, vol. 78, no. 3, 2008, pp. 523-32.
Xu X, Wan W, Ji L, et al. Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats. Cardiovasc Res. 2008;78(3):523-32.
Xu, X., Wan, W., Ji, L., Lao, S., Powers, A. S., Zhao, W., Erikson, J. M., & Zhang, J. Q. (2008). Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats. Cardiovascular Research, 78(3), 523-32. https://doi.org/10.1093/cvr/cvn028
Xu X, et al. Exercise Training Combined With Angiotensin II Receptor Blockade Limits Post-infarct Ventricular Remodelling in Rats. Cardiovasc Res. 2008 Jun 1;78(3):523-32. PubMed PMID: 18252761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats. AU - Xu,Xiaohua, AU - Wan,Wenhan, AU - Ji,Lisa, AU - Lao,Shunhua, AU - Powers,Anthony S, AU - Zhao,Weiyan, AU - Erikson,John M, AU - Zhang,John Q, Y1 - 2008/02/05/ PY - 2008/2/7/pubmed PY - 2008/9/10/medline PY - 2008/2/7/entrez SP - 523 EP - 32 JF - Cardiovascular research JO - Cardiovasc Res VL - 78 IS - 3 N2 - AIMS: Our aim was to test the hypothesis that angiotensin II receptor blockade combined with exercise training after myocardial infarction (MI) could attenuate post-MI left ventricular remodelling and preserve cardiac function. METHODS AND RESULTS: Sprague-Dawley rats underwent ligation of the left descending coronary artery, resulting in MI, or a sham operation. Losartan treatment and exercise training were initiated 1 week after infarction and continued for 8 weeks, either as a single intervention or combined. Collagen volume fraction in the sedentary MI (MISed) group was significantly higher than other MI groups treated with exercise training and/or losartan. Compared with MISed group, hearts of rats receiving exercise and/or losartan treatment had lower tissue inhibitor of matrix metalloproteinase (TIMP) 1. Matrix metalloproteinase (MMP) 2 or MMP-9 did not differ among all groups. Additionally, the level of angiotensin II receptor type 1 (AT1) protein significantly decreased in response to exercise training. Furthermore, angiotensin converting enzyme (ACE) binding was markedly lower in hearts receiving exercise training than in the MISed hearts. Cardiac function was preserved in rats receiving exercise training, and the beneficial effect was further improved by exercise combined with losartan treatment in comparison to the MISed group. CONCLUSION: Our results suggest that post-MI exercise training and/or AngII receptor blockade reduces TIMP-1 expression and mitigates the expressions of ACE and AT1 receptor. These improvements, in turn, attenuate myocardial fibrosis and preserve post-MI cardiac function. SN - 0008-6363 UR - https://www.unboundmedicine.com/medline/citation/18252761/Exercise_training_combined_with_angiotensin_II_receptor_blockade_limits_post_infarct_ventricular_remodelling_in_rats_ L2 - https://academic.oup.com/cardiovascres/article-lookup/doi/10.1093/cvr/cvn028 DB - PRIME DP - Unbound Medicine ER -