Tags

Type your tag names separated by a space and hit enter

Determinants of changes in blood glucose response to short-term exercise training in patients with Type 2 diabetes.
Clin Sci (Lond) 2008; 115(9):273-81CS

Abstract

The aim of the present study was to determine the effects of a 4-week exercise training intervention on blood glucose, insulin sensitivity, BMI (body mass index) and cardiorespiratory fitness in patients with Type 2 diabetes, and to identify and establish criteria for patients who are more likely to improve their blood glucose from short-term exercise training. A randomized, controlled trial of exercise training, comprising two supervised and one non-supervised sessions of individualized cardiorespiratory and resistance exercise per week, was performed in 132 healthy patients with Type 2 diabetes (exercise training group, n=68), with the aim of accumulating a minimum of 150 min of moderate-intensity exercise for 4 weeks. BMI, waist circumference, blood pressure, blood lipid profile, blood glucose, insulin, insulin sensitivity [calculated by HOMA(IR) (homoeostasis model assessment of insulin resistance) and QUICKI (quantitative insulin check index)], beta-cell function (calculated by HOMA(beta-Cell)), HbA(1c) (glycated haemoglobin) and VO(2max) (maximal oxygen consumption) were measured at baseline and at 4 weeks. The exercise training group had significant improvements in VO(2max), BMI and triacylglycerols (triglycerides). There were no significant changes in blood glucose, HOMA(IR), QUICKI or HOMA(beta-Cell). Decreases in blood glucose were significantly predicted by baseline blood glucose and HbA(1c), with these variables accounting for 15.9% of the change in blood glucose (P<0.001). ROC (receiver operator characteristic) curve analysis revealed that patients with a blood glucose >8.85 mmol/l (sensitivity=73%, specificity=78%) and HbA(1c) >7.15% (sensitivity=79%, specificity=60%) were more likely to achieve a clinically significant decrease in blood glucose. In conclusion, in apparently healthy patients with Type 2 diabetes, a 4-week exercise intervention improved cardiorespiratory fitness, BMI and triacylglycerols. Elevated blood glucose and HbA(1c) predicted improvements in blood glucose.

Authors+Show Affiliations

School of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia. m.hordern@uq.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18254721

Citation

Hordern, Matthew D., et al. "Determinants of Changes in Blood Glucose Response to Short-term Exercise Training in Patients With Type 2 Diabetes." Clinical Science (London, England : 1979), vol. 115, no. 9, 2008, pp. 273-81.
Hordern MD, Cooney LM, Beller EM, et al. Determinants of changes in blood glucose response to short-term exercise training in patients with Type 2 diabetes. Clin Sci. 2008;115(9):273-81.
Hordern, M. D., Cooney, L. M., Beller, E. M., Prins, J. B., Marwick, T. H., & Coombes, J. S. (2008). Determinants of changes in blood glucose response to short-term exercise training in patients with Type 2 diabetes. Clinical Science (London, England : 1979), 115(9), pp. 273-81. doi:10.1042/CS20070422.
Hordern MD, et al. Determinants of Changes in Blood Glucose Response to Short-term Exercise Training in Patients With Type 2 Diabetes. Clin Sci. 2008;115(9):273-81. PubMed PMID: 18254721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determinants of changes in blood glucose response to short-term exercise training in patients with Type 2 diabetes. AU - Hordern,Matthew D, AU - Cooney,Louise M, AU - Beller,Elaine M, AU - Prins,Johannes B, AU - Marwick,Thomas H, AU - Coombes,Jeff S, PY - 2008/2/8/pubmed PY - 2008/12/17/medline PY - 2008/2/8/entrez SP - 273 EP - 81 JF - Clinical science (London, England : 1979) JO - Clin. Sci. VL - 115 IS - 9 N2 - The aim of the present study was to determine the effects of a 4-week exercise training intervention on blood glucose, insulin sensitivity, BMI (body mass index) and cardiorespiratory fitness in patients with Type 2 diabetes, and to identify and establish criteria for patients who are more likely to improve their blood glucose from short-term exercise training. A randomized, controlled trial of exercise training, comprising two supervised and one non-supervised sessions of individualized cardiorespiratory and resistance exercise per week, was performed in 132 healthy patients with Type 2 diabetes (exercise training group, n=68), with the aim of accumulating a minimum of 150 min of moderate-intensity exercise for 4 weeks. BMI, waist circumference, blood pressure, blood lipid profile, blood glucose, insulin, insulin sensitivity [calculated by HOMA(IR) (homoeostasis model assessment of insulin resistance) and QUICKI (quantitative insulin check index)], beta-cell function (calculated by HOMA(beta-Cell)), HbA(1c) (glycated haemoglobin) and VO(2max) (maximal oxygen consumption) were measured at baseline and at 4 weeks. The exercise training group had significant improvements in VO(2max), BMI and triacylglycerols (triglycerides). There were no significant changes in blood glucose, HOMA(IR), QUICKI or HOMA(beta-Cell). Decreases in blood glucose were significantly predicted by baseline blood glucose and HbA(1c), with these variables accounting for 15.9% of the change in blood glucose (P<0.001). ROC (receiver operator characteristic) curve analysis revealed that patients with a blood glucose >8.85 mmol/l (sensitivity=73%, specificity=78%) and HbA(1c) >7.15% (sensitivity=79%, specificity=60%) were more likely to achieve a clinically significant decrease in blood glucose. In conclusion, in apparently healthy patients with Type 2 diabetes, a 4-week exercise intervention improved cardiorespiratory fitness, BMI and triacylglycerols. Elevated blood glucose and HbA(1c) predicted improvements in blood glucose. SN - 1470-8736 UR - https://www.unboundmedicine.com/medline/citation/18254721/Determinants_of_changes_in_blood_glucose_response_to_short_term_exercise_training_in_patients_with_Type_2_diabetes_ L2 - http://clinsci.org/cgi/pmidlookup?view=long&amp;pmid=18254721 DB - PRIME DP - Unbound Medicine ER -