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Interaction of amphotericin B lipid formulations and triazoles with human polymorphonuclear leucocytes for antifungal activity against Zygomycetes.
Mycoses. 2008 Mar; 51(2):147-54.M

Abstract

The frequency of zygomycosis has increased considerably over recent years mainly in immunocompromised and diabetic patients. Little is known about the effects of host innate immunity against different Zygomycetes especially under the influence of antifungal agents. The antifungal activity of human polymorphonuclear leucocytes (PMN) in combination with liposomal amphotericin B (LAMB), amphotericin B lipid complex (ABLC), voriconazole (VRC) and posaconazole (PSC) against Rhizopus oryzae and Rhizopus microsporus, frequently isolated Zygomycetes, were studied and compared with Absidia corymbifera, a less pathogenic Zygomycete. Antifungal activity was evaluated as per cent of hyphal damage using the XTT metabolic assay. While A. corymbifera was more susceptible to PMN than the other two Zygomycetes, R. microsporus appeared to be the most susceptible to combined effects of amphotericin B formulations and VRC with PMN. LAMB exhibited synergistic activity with PMN in inducing hyphal damage to R. microsporus but not to the other fungi. In contrast, ABLC exhibited synergistic or additive activity with PMN against all three fungi. Among triazoles, only VRC exhibited additive effect with PMN against R. microsporus. Lipid formulations of amphotericin B and particularly ABLC interact with PMN predominantly in inducing augmented hyphal damage to three different species of Zygomycetes.

Authors+Show Affiliations

Laboratory of Infectious Diseases, Third Department of Pediatrics, Aristotle University, Hippokration Hospital, Thessaloniki, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18254752

Citation

Simitsopoulou, Maria, et al. "Interaction of Amphotericin B Lipid Formulations and Triazoles With Human Polymorphonuclear Leucocytes for Antifungal Activity Against Zygomycetes." Mycoses, vol. 51, no. 2, 2008, pp. 147-54.
Simitsopoulou M, Roilides E, Maloukou A, et al. Interaction of amphotericin B lipid formulations and triazoles with human polymorphonuclear leucocytes for antifungal activity against Zygomycetes. Mycoses. 2008;51(2):147-54.
Simitsopoulou, M., Roilides, E., Maloukou, A., Gil-Lamaignere, C., & Walsh, T. J. (2008). Interaction of amphotericin B lipid formulations and triazoles with human polymorphonuclear leucocytes for antifungal activity against Zygomycetes. Mycoses, 51(2), 147-54. https://doi.org/10.1111/j.1439-0507.2007.01457.x
Simitsopoulou M, et al. Interaction of Amphotericin B Lipid Formulations and Triazoles With Human Polymorphonuclear Leucocytes for Antifungal Activity Against Zygomycetes. Mycoses. 2008;51(2):147-54. PubMed PMID: 18254752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of amphotericin B lipid formulations and triazoles with human polymorphonuclear leucocytes for antifungal activity against Zygomycetes. AU - Simitsopoulou,Maria, AU - Roilides,Emmanuel, AU - Maloukou,Avgi, AU - Gil-Lamaignere,Cristina, AU - Walsh,Thomas J, PY - 2008/2/8/pubmed PY - 2008/3/25/medline PY - 2008/2/8/entrez SP - 147 EP - 54 JF - Mycoses JO - Mycoses VL - 51 IS - 2 N2 - The frequency of zygomycosis has increased considerably over recent years mainly in immunocompromised and diabetic patients. Little is known about the effects of host innate immunity against different Zygomycetes especially under the influence of antifungal agents. The antifungal activity of human polymorphonuclear leucocytes (PMN) in combination with liposomal amphotericin B (LAMB), amphotericin B lipid complex (ABLC), voriconazole (VRC) and posaconazole (PSC) against Rhizopus oryzae and Rhizopus microsporus, frequently isolated Zygomycetes, were studied and compared with Absidia corymbifera, a less pathogenic Zygomycete. Antifungal activity was evaluated as per cent of hyphal damage using the XTT metabolic assay. While A. corymbifera was more susceptible to PMN than the other two Zygomycetes, R. microsporus appeared to be the most susceptible to combined effects of amphotericin B formulations and VRC with PMN. LAMB exhibited synergistic activity with PMN in inducing hyphal damage to R. microsporus but not to the other fungi. In contrast, ABLC exhibited synergistic or additive activity with PMN against all three fungi. Among triazoles, only VRC exhibited additive effect with PMN against R. microsporus. Lipid formulations of amphotericin B and particularly ABLC interact with PMN predominantly in inducing augmented hyphal damage to three different species of Zygomycetes. SN - 1439-0507 UR - https://www.unboundmedicine.com/medline/citation/18254752/Interaction_of_amphotericin_B_lipid_formulations_and_triazoles_with_human_polymorphonuclear_leucocytes_for_antifungal_activity_against_Zygomycetes_ L2 - https://doi.org/10.1111/j.1439-0507.2007.01457.x DB - PRIME DP - Unbound Medicine ER -