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A novel treatment option for photoaged skin.
J Cosmet Dermatol. 2008 Mar; 7(1):15-22.JC

Abstract

BACKGROUND

DNA damage as a result of ultraviolet (UV) exposure plays an important role in the progression of cutaneous aging. Both folic acid and creatine have been linked to the process of DNA protection and repair.

AIMS

This study aims to investigate the effects of a commercially available folic acid- and creatine-containing formulation to fight the clinical signs of premature skin aging.

PATIENTS/METHODS

Both in vitro and in vivo home-in-use studies using a folic acid- and creatine-containing formulation were performed aiming to elucidate the efficacy in terms of improvement of skin regeneration, protection from UV-induced DNA damage (Comet assay), reduction of wrinkle volume, and skin visco-elasticity. Furthermore, clinical evaluation and photography were carried out to determine the improvement of clinically graded parameters after treatment.

RESULTS

Cultured full-thickness epidermal skin models supplemented with folic acid and creatine after epithelial perturbation showed an accelerated skin regeneration compared to untreated control models. Similarly, application of a folic acid- and creatine-containing formulation significantly improved epidermal turnover in vivo as evidenced by smaller corneocytes derived from the treated sites relative to the vehicle-treated sides. In addition, topical in vivo application of this formulation significantly protected from UV-induced DNA lesions, increased skin firmness, and reduced wrinkle volume compared to untreated control areas. Expert grading confirmed a significant decrease of fine and coarse wrinkles in the periocular region as well as overall wrinkles, tactile roughness, and laxity.

CONCLUSIONS

Taken together, these results show that the combination of folic acid and creatine significantly accelerates epidermal skin regeneration in vitro and in vivo. Together with the finding of improved biomechanical skin properties, we conclude that the described topical formulation provides an effective treatment option for (photo)-aged skin.

Authors+Show Affiliations

Research & Development, Beiersdorf AG, Hamburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18254806

Citation

Knott, Anja, et al. "A Novel Treatment Option for Photoaged Skin." Journal of Cosmetic Dermatology, vol. 7, no. 1, 2008, pp. 15-22.
Knott A, Koop U, Mielke H, et al. A novel treatment option for photoaged skin. J Cosmet Dermatol. 2008;7(1):15-22.
Knott, A., Koop, U., Mielke, H., Reuschlein, K., Peters, N., Muhr, G. M., Lenz, H., Wensorra, U., Jaspers, S., Kolbe, L., Raschke, T., Stäb, F., Wenck, H., & Gallinat, S. (2008). A novel treatment option for photoaged skin. Journal of Cosmetic Dermatology, 7(1), 15-22. https://doi.org/10.1111/j.1473-2165.2008.00356.x
Knott A, et al. A Novel Treatment Option for Photoaged Skin. J Cosmet Dermatol. 2008;7(1):15-22. PubMed PMID: 18254806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel treatment option for photoaged skin. AU - Knott,Anja, AU - Koop,Urte, AU - Mielke,Heiko, AU - Reuschlein,Katja, AU - Peters,Nils, AU - Muhr,Gesa-Meike, AU - Lenz,Holger, AU - Wensorra,Ursula, AU - Jaspers,Sören, AU - Kolbe,Ludger, AU - Raschke,Thomas, AU - Stäb,Franz, AU - Wenck,Horst, AU - Gallinat,Stefan, PY - 2008/2/8/pubmed PY - 2008/5/6/medline PY - 2008/2/8/entrez SP - 15 EP - 22 JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol VL - 7 IS - 1 N2 - BACKGROUND: DNA damage as a result of ultraviolet (UV) exposure plays an important role in the progression of cutaneous aging. Both folic acid and creatine have been linked to the process of DNA protection and repair. AIMS: This study aims to investigate the effects of a commercially available folic acid- and creatine-containing formulation to fight the clinical signs of premature skin aging. PATIENTS/METHODS: Both in vitro and in vivo home-in-use studies using a folic acid- and creatine-containing formulation were performed aiming to elucidate the efficacy in terms of improvement of skin regeneration, protection from UV-induced DNA damage (Comet assay), reduction of wrinkle volume, and skin visco-elasticity. Furthermore, clinical evaluation and photography were carried out to determine the improvement of clinically graded parameters after treatment. RESULTS: Cultured full-thickness epidermal skin models supplemented with folic acid and creatine after epithelial perturbation showed an accelerated skin regeneration compared to untreated control models. Similarly, application of a folic acid- and creatine-containing formulation significantly improved epidermal turnover in vivo as evidenced by smaller corneocytes derived from the treated sites relative to the vehicle-treated sides. In addition, topical in vivo application of this formulation significantly protected from UV-induced DNA lesions, increased skin firmness, and reduced wrinkle volume compared to untreated control areas. Expert grading confirmed a significant decrease of fine and coarse wrinkles in the periocular region as well as overall wrinkles, tactile roughness, and laxity. CONCLUSIONS: Taken together, these results show that the combination of folic acid and creatine significantly accelerates epidermal skin regeneration in vitro and in vivo. Together with the finding of improved biomechanical skin properties, we conclude that the described topical formulation provides an effective treatment option for (photo)-aged skin. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/18254806/A_novel_treatment_option_for_photoaged_skin_ L2 - https://doi.org/10.1111/j.1473-2165.2008.00356.x DB - PRIME DP - Unbound Medicine ER -