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Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.
Bioorg Med Chem Lett. 2008 Mar 01; 18(5):1725-9.BM

Abstract

A high-throughput screening campaign resulted in the discovery of a highly potent dual cannabinoid receptor 1 (CB1) and 2 (CB2) agonist. Following a thorough SAR exploration, a series of selective CB2 full agonists were identified.

Authors+Show Affiliations

Evotec (UK) Ltd., 114 Milton Park, Abingdon, Oxfordshire OX14 4SA, United Kingdom. monika.ermann@evotec.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18255291

Citation

Ermann, Monika, et al. "Arylsulfonamide CB2 Receptor Agonists: SAR and Optimization of CB2 Selectivity." Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 5, 2008, pp. 1725-9.
Ermann M, Riether D, Walker ER, et al. Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity. Bioorg Med Chem Lett. 2008;18(5):1725-9.
Ermann, M., Riether, D., Walker, E. R., Mushi, I. F., Jenkins, J. E., Noya-Marino, B., Brewer, M. L., Taylor, M. G., Amouzegh, P., East, S. P., Dymock, B. W., Gemkow, M. J., Kahrs, A. F., Ebneth, A., Löbbe, S., O'Shea, K., Shih, D. T., & Thomson, D. (2008). Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity. Bioorganic & Medicinal Chemistry Letters, 18(5), 1725-9. https://doi.org/10.1016/j.bmcl.2008.01.042
Ermann M, et al. Arylsulfonamide CB2 Receptor Agonists: SAR and Optimization of CB2 Selectivity. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1725-9. PubMed PMID: 18255291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity. AU - Ermann,Monika, AU - Riether,Doris, AU - Walker,Edward R, AU - Mushi,Innocent F, AU - Jenkins,James E, AU - Noya-Marino,Beatriz, AU - Brewer,Mark L, AU - Taylor,Malcolm G, AU - Amouzegh,Patricia, AU - East,Stephen P, AU - Dymock,Brian W, AU - Gemkow,Mark J, AU - Kahrs,Andreas F, AU - Ebneth,Andreas, AU - Löbbe,Sabine, AU - O'Shea,Kathy, AU - Shih,Daw-Tsun, AU - Thomson,David, Y1 - 2008/01/18/ PY - 2007/12/03/received PY - 2008/01/11/revised PY - 2008/01/12/accepted PY - 2008/2/8/pubmed PY - 2008/5/20/medline PY - 2008/2/8/entrez SP - 1725 EP - 9 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 18 IS - 5 N2 - A high-throughput screening campaign resulted in the discovery of a highly potent dual cannabinoid receptor 1 (CB1) and 2 (CB2) agonist. Following a thorough SAR exploration, a series of selective CB2 full agonists were identified. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/18255291/Arylsulfonamide_CB2_receptor_agonists:_SAR_and_optimization_of_CB2_selectivity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(08)00057-7 DB - PRIME DP - Unbound Medicine ER -