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[The role of omega-3 fatty acids from fish in prevention of cardiovascular diseases].
Lijec Vjesn 2007 Oct-Nov; 129(10-11):350-5LV

Abstract

Fish and fish oil are rich sources of omega-3 fatty acids--essential polyunsaturated fatty acids. These acids in doses of 1 g per day have been shown to significantly reduce the all-cause mortality in post myocardial infarction (MI) patients and the risk for sudden death caused by cardiac arrhythmias. One of the recently most studied mechanisms that may contribute to this benefits of omega-3 fatty acids is their anti-arrhythmic effect. Namely, these acids influence membrane ion channels, increase ventricular fibrillation threshold and increase heart rate variability. Although the data concerning primary prevention is less straightforward than the data relating secondary prevention, it seems that the use of omega-3 fatty acids in primary prevention might be justified as well. In higher doses (2 to 4 g per day) they are used to treat hypertriglyceridemia. Potential mechanisms by which omega-3 fatty acids may reduce risk for cardiovascular disease include also antithrombotic (they decrease platelet aggregation/reactivity, reduce plasma viscosity, enhance fibrinolysis) and anti-inflammatory effects (e.g. they decrease IL-6, MCP-1, TNF), improving vascular endothelial cell function (e.g. they increase availability of nitric oxide), reducing expression of endothelial cells adhesion molecules, inhibiting smooth muscle cells migration and proliferation, and reducing blood pressure. Based upon clinical studies the use of omega-3 fatty acids should be considered today at least as a part of comprehensive secondary prevention strategy in post-MI patients. It has been also shown that adding highly concentrated omega-3 fatty acids to standard treatment in the secondary prevention of MI is cost effective versus standard treatment alone. Particularly important is that there are no significant drug interactions with omega-3 fatty acids.

Authors+Show Affiliations

Klinika za unutarnje bolesti Medicinskog fakulteta, KBC Zagreb.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

hrv

PubMed ID

18257336

Citation

Reiner, Eljko, et al. "[The Role of Omega-3 Fatty Acids From Fish in Prevention of Cardiovascular Diseases]." Lijecnicki Vjesnik, vol. 129, no. 10-11, 2007, pp. 350-5.
Reiner E, Tedeschi-Reiner E, Stajminger G. [The role of omega-3 fatty acids from fish in prevention of cardiovascular diseases]. Lijec Vjesn. 2007;129(10-11):350-5.
Reiner, E., Tedeschi-Reiner, E., & Stajminger, G. (2007). [The role of omega-3 fatty acids from fish in prevention of cardiovascular diseases]. Lijecnicki Vjesnik, 129(10-11), pp. 350-5.
Reiner E, Tedeschi-Reiner E, Stajminger G. [The Role of Omega-3 Fatty Acids From Fish in Prevention of Cardiovascular Diseases]. Lijec Vjesn. 2007;129(10-11):350-5. PubMed PMID: 18257336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The role of omega-3 fatty acids from fish in prevention of cardiovascular diseases]. AU - Reiner,Eljko, AU - Tedeschi-Reiner,Eugenia, AU - Stajminger,Gordana, PY - 2008/2/9/pubmed PY - 2008/4/4/medline PY - 2008/2/9/entrez SP - 350 EP - 5 JF - Lijecnicki vjesnik JO - Lijec Vjesn VL - 129 IS - 10-11 N2 - Fish and fish oil are rich sources of omega-3 fatty acids--essential polyunsaturated fatty acids. These acids in doses of 1 g per day have been shown to significantly reduce the all-cause mortality in post myocardial infarction (MI) patients and the risk for sudden death caused by cardiac arrhythmias. One of the recently most studied mechanisms that may contribute to this benefits of omega-3 fatty acids is their anti-arrhythmic effect. Namely, these acids influence membrane ion channels, increase ventricular fibrillation threshold and increase heart rate variability. Although the data concerning primary prevention is less straightforward than the data relating secondary prevention, it seems that the use of omega-3 fatty acids in primary prevention might be justified as well. In higher doses (2 to 4 g per day) they are used to treat hypertriglyceridemia. Potential mechanisms by which omega-3 fatty acids may reduce risk for cardiovascular disease include also antithrombotic (they decrease platelet aggregation/reactivity, reduce plasma viscosity, enhance fibrinolysis) and anti-inflammatory effects (e.g. they decrease IL-6, MCP-1, TNF), improving vascular endothelial cell function (e.g. they increase availability of nitric oxide), reducing expression of endothelial cells adhesion molecules, inhibiting smooth muscle cells migration and proliferation, and reducing blood pressure. Based upon clinical studies the use of omega-3 fatty acids should be considered today at least as a part of comprehensive secondary prevention strategy in post-MI patients. It has been also shown that adding highly concentrated omega-3 fatty acids to standard treatment in the secondary prevention of MI is cost effective versus standard treatment alone. Particularly important is that there are no significant drug interactions with omega-3 fatty acids. SN - 0024-3477 UR - https://www.unboundmedicine.com/medline/citation/18257336/[The_role_of_omega_3_fatty_acids_from_fish_in_prevention_of_cardiovascular_diseases]_ DB - PRIME DP - Unbound Medicine ER -