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A study of the properties of tablets from coprocessed dry binders composed of alpha-lactose monohydrate and different types of cellulose.
Ceska Slov Farm. 2007 Dec; 56(6):269-75.CS

Abstract

The paper evaluates the differences between the properties of tablets from two coprocessed dry binders based on alpha-lactose monohydrate and cellulose, MicroceLac 100 and Cellactose 80. The substances differ in the type of contained cellulose; MicroceLac 100 contains 25% of microcrystalline cellulose, Cellactose 80, 25% of powdered cellulose. The properties under study included the tensile strength and disintegration time in dependence on compression force, addition of two concentrations of the lubricant sodium stearylfumarate (Pruv) and a 50% addition of the active ingredients ascorbic acid and acetylsalicylic acid. Using one of the compression forces, the effect of Pruv and magnesium stearate on the above-mentioned properties were compared. In the compression forces of 6 and 8 kN the strength of the compacts from pure Cellactose 80 was lower than that of those from MicroceLac 100 both without and with the lubricant. The lubricant sensitivity of dry binders depended on compression force. Pruv decreased the strength of compacts less than magnesium stearate. The tablets from Cellactose 80 possessed a longer disintegration time than those from MicroceLac 100, excepting the tableting materials containing 0.4 Pruv with a compression force of 6 kN. Disintegration time was prolonged with the use of sodium stearylfumarate and it was increased with compression force much more markedly in the case of Cellactose 80. In the presence of ascorbic acid, the strength of tablets was decreased in the case of both dry binders, but it was higher with MicroceLac100, disintegration time was very short and independent of the type of the dry binder. In the case of acetylsalicylic acid, the strength of tablets was higher with a lesser influence of the type of the dry binder, and disintegration time was longer and especially in the case of Cellactose 80 increased with increasing concentration of Pruv.

Authors+Show Affiliations

Muzíková J
Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic. muzikova@faf.cuni.cz
Zvolánková J
No affiliation info available

MeSH

CelluloseLactosePharmaceutic AidsTabletsTechnology, PharmaceuticalTensile Strength

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18257417

Citation

Muzíková, J, and J Zvolánková. "A Study of the Properties of Tablets From Coprocessed Dry Binders Composed of Alpha-lactose Monohydrate and Different Types of Cellulose." Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, vol. 56, no. 6, 2007, pp. 269-75.
Muzíková J, Zvolánková J. A study of the properties of tablets from coprocessed dry binders composed of alpha-lactose monohydrate and different types of cellulose. Ceska Slov Farm. 2007;56(6):269-75.
Muzíková, J., & Zvolánková, J. (2007). A study of the properties of tablets from coprocessed dry binders composed of alpha-lactose monohydrate and different types of cellulose. Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, 56(6), 269-75.
Muzíková J, Zvolánková J. A Study of the Properties of Tablets From Coprocessed Dry Binders Composed of Alpha-lactose Monohydrate and Different Types of Cellulose. Ceska Slov Farm. 2007;56(6):269-75. PubMed PMID: 18257417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study of the properties of tablets from coprocessed dry binders composed of alpha-lactose monohydrate and different types of cellulose. AU - Muzíková,J, AU - Zvolánková,J, PY - 2008/2/9/pubmed PY - 2008/4/4/medline PY - 2008/2/9/entrez SP - 269 EP - 75 JF - Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti JO - Ceska Slov Farm VL - 56 IS - 6 N2 - The paper evaluates the differences between the properties of tablets from two coprocessed dry binders based on alpha-lactose monohydrate and cellulose, MicroceLac 100 and Cellactose 80. The substances differ in the type of contained cellulose; MicroceLac 100 contains 25% of microcrystalline cellulose, Cellactose 80, 25% of powdered cellulose. The properties under study included the tensile strength and disintegration time in dependence on compression force, addition of two concentrations of the lubricant sodium stearylfumarate (Pruv) and a 50% addition of the active ingredients ascorbic acid and acetylsalicylic acid. Using one of the compression forces, the effect of Pruv and magnesium stearate on the above-mentioned properties were compared. In the compression forces of 6 and 8 kN the strength of the compacts from pure Cellactose 80 was lower than that of those from MicroceLac 100 both without and with the lubricant. The lubricant sensitivity of dry binders depended on compression force. Pruv decreased the strength of compacts less than magnesium stearate. The tablets from Cellactose 80 possessed a longer disintegration time than those from MicroceLac 100, excepting the tableting materials containing 0.4 Pruv with a compression force of 6 kN. Disintegration time was prolonged with the use of sodium stearylfumarate and it was increased with compression force much more markedly in the case of Cellactose 80. In the presence of ascorbic acid, the strength of tablets was decreased in the case of both dry binders, but it was higher with MicroceLac100, disintegration time was very short and independent of the type of the dry binder. In the case of acetylsalicylic acid, the strength of tablets was higher with a lesser influence of the type of the dry binder, and disintegration time was longer and especially in the case of Cellactose 80 increased with increasing concentration of Pruv. SN - 1210-7816 UR - https://www.unboundmedicine.com/medline/citation/18257417/A_study_of_the_properties_of_tablets_from_coprocessed_dry_binders_composed_of_alpha_lactose_monohydrate_and_different_types_of_cellulose_ DB - PRIME DP - Unbound Medicine ER -