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CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy.
HIV Med. 2008 Feb; 9(2):118-25.HM

Abstract

OBJECTIVE

The aim of the study was to determine whether the expression of CD38 on CD8 T cells can identify patients with virological failure on antiretroviral therapy (ART).

DESIGN

This was a cross-sectional study of patients attending a single HIV clinic in London.

METHODS

The expression of CD38 on CD8 T cells was assessed using a biologically calibrated flow cytometry protocol. Patients were characterized by lymphocyte subset and viral load measurements. Characteristics including historical CD4 T cell counts, therapeutic history, co-infections and demographics were obtained from medical records.

RESULTS

Elevated levels of CD8 CD38(high) T cells were found in HIV-1-infected patients who failed to suppress viral replication with ART; however, this parameter lacked sufficient sensitivity and specificity to replace viral load testing in assessing the efficacy of ART. Increased levels of CD8 CD38(high) cells were associated with reduced CD4 T cell counts in HIV-1-infected patients on ART after correcting for known determinants of CD4 T-cell recovery.

CONCLUSIONS

The expression of CD38 on CD8 T cells lacks sufficient sensitivity and specificity to be used as a surrogate marker for viral load to monitor HIV-1 infection. T-cell activation is associated with reduced CD4 T-cell reconstitution in patients receiving ART.

Authors+Show Affiliations

Department of Immunology, Imperial College, Chelsea & Westminster Hospital, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18257774

Citation

Steel, A, et al. "CD38 Expression On CD8 T Cells Has a Weak Association With CD4 T-cell Recovery and Is a Poor Marker of Viral Replication in HIV-1-infected Patients On Antiretroviral Therapy." HIV Medicine, vol. 9, no. 2, 2008, pp. 118-25.
Steel A, John L, Shamji MH, et al. CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy. HIV Med. 2008;9(2):118-25.
Steel, A., John, L., Shamji, M. H., Henderson, D. C., Gotch, F. M., Gazzard, B. G., & Kelleher, P. (2008). CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy. HIV Medicine, 9(2), 118-25. https://doi.org/10.1111/j.1468-1293.2007.00528.x
Steel A, et al. CD38 Expression On CD8 T Cells Has a Weak Association With CD4 T-cell Recovery and Is a Poor Marker of Viral Replication in HIV-1-infected Patients On Antiretroviral Therapy. HIV Med. 2008;9(2):118-25. PubMed PMID: 18257774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy. AU - Steel,A, AU - John,L, AU - Shamji,M H, AU - Henderson,D C, AU - Gotch,F M, AU - Gazzard,B G, AU - Kelleher,P, PY - 2008/2/9/pubmed PY - 2008/8/15/medline PY - 2008/2/9/entrez SP - 118 EP - 25 JF - HIV medicine JO - HIV Med VL - 9 IS - 2 N2 - OBJECTIVE: The aim of the study was to determine whether the expression of CD38 on CD8 T cells can identify patients with virological failure on antiretroviral therapy (ART). DESIGN: This was a cross-sectional study of patients attending a single HIV clinic in London. METHODS: The expression of CD38 on CD8 T cells was assessed using a biologically calibrated flow cytometry protocol. Patients were characterized by lymphocyte subset and viral load measurements. Characteristics including historical CD4 T cell counts, therapeutic history, co-infections and demographics were obtained from medical records. RESULTS: Elevated levels of CD8 CD38(high) T cells were found in HIV-1-infected patients who failed to suppress viral replication with ART; however, this parameter lacked sufficient sensitivity and specificity to replace viral load testing in assessing the efficacy of ART. Increased levels of CD8 CD38(high) cells were associated with reduced CD4 T cell counts in HIV-1-infected patients on ART after correcting for known determinants of CD4 T-cell recovery. CONCLUSIONS: The expression of CD38 on CD8 T cells lacks sufficient sensitivity and specificity to be used as a surrogate marker for viral load to monitor HIV-1 infection. T-cell activation is associated with reduced CD4 T-cell reconstitution in patients receiving ART. SN - 1464-2662 UR - https://www.unboundmedicine.com/medline/citation/18257774/CD38_expression_on_CD8_T_cells_has_a_weak_association_with_CD4_T_cell_recovery_and_is_a_poor_marker_of_viral_replication_in_HIV_1_infected_patients_on_antiretroviral_therapy_ L2 - https://doi.org/10.1111/j.1468-1293.2007.00528.x DB - PRIME DP - Unbound Medicine ER -