Tags

Type your tag names separated by a space and hit enter

No effect of 5-day treatment with acetylsalicylic acid (aspirin) or the beta-blocker propranolol (Inderal) on free cortisol responses to acute psychosocial stress: a randomized double-blind, placebo-controlled study.
Neuropsychobiology. 2007; 56(2-3):159-66.N

Abstract

BACKGROUND

The characterization of an individual's hypothalamic-pituitary-adrenal axis stress response is a main research topic in neuropsychobiology since alterations have been causally linked to several disease states. Over the last years, several studies focused on the identification of sources of inter- and intraindividual variability, but there is still a paucity of experimental data on the effect of different pharmaceuticals on cortisol responses to acute psychological stress. Therefore, in this randomized double-blind placebo-controlled study, we investigated the effect of treatment with two popular and clinically used pharmaceuticals on stress-related cortisol responses, namely acetylsalicylic acid (aspirin), a known prostaglandin synthesis inhibitor, and the beta-blocker propranolol (Inderal), a nonselective beta-receptor antagonist.

METHODS

For 5 days, 73 healthy subjects (50 men, 23 women; mean age 47.3 +/- 7.7 years) received either a daily oral dose of 100 mg aspirin, 80 mg propranolol (Inderal), aspirin + propranolol, or placebo. After treatment, subjects were confronted with the Trier Social Stress Test, a widely-used standardized psychosocial stress protocol. Cortisol responses were measured by six saliva samples taken before and after the stress exposure.

RESULTS

Subjects showed a significant cortisol increase after stress (p < 0.0001). The four treatment groups did not differ in their cortisol responses (group effect p > 0.44; interaction p > 0.97). Additionally, controlling for gender, age, smoking status, body mass index, mean arterial blood pressure or pre-stress cortisol levels yielded similar results in the total sample as well as in the male or female subgroups, respectively.

CONCLUSION

Neither short-term treatment with aspirin nor propranolol altered the acute free cortisol response to psychological stress in healthy adults.

Authors+Show Affiliations

Department of Theoretical and Clinical Psychobiology, Graduate School of Psychobiology, University of Trier, Trier, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18259090

Citation

Kudielka, Brigitte M., et al. "No Effect of 5-day Treatment With Acetylsalicylic Acid (aspirin) or the Beta-blocker Propranolol (Inderal) On Free Cortisol Responses to Acute Psychosocial Stress: a Randomized Double-blind, Placebo-controlled Study." Neuropsychobiology, vol. 56, no. 2-3, 2007, pp. 159-66.
Kudielka BM, Fischer JE, Metzenthin P, et al. No effect of 5-day treatment with acetylsalicylic acid (aspirin) or the beta-blocker propranolol (Inderal) on free cortisol responses to acute psychosocial stress: a randomized double-blind, placebo-controlled study. Neuropsychobiology. 2007;56(2-3):159-66.
Kudielka, B. M., Fischer, J. E., Metzenthin, P., Helfricht, S., Preckel, D., & von Känel, R. (2007). No effect of 5-day treatment with acetylsalicylic acid (aspirin) or the beta-blocker propranolol (Inderal) on free cortisol responses to acute psychosocial stress: a randomized double-blind, placebo-controlled study. Neuropsychobiology, 56(2-3), 159-66. https://doi.org/10.1159/000115783
Kudielka BM, et al. No Effect of 5-day Treatment With Acetylsalicylic Acid (aspirin) or the Beta-blocker Propranolol (Inderal) On Free Cortisol Responses to Acute Psychosocial Stress: a Randomized Double-blind, Placebo-controlled Study. Neuropsychobiology. 2007;56(2-3):159-66. PubMed PMID: 18259090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No effect of 5-day treatment with acetylsalicylic acid (aspirin) or the beta-blocker propranolol (Inderal) on free cortisol responses to acute psychosocial stress: a randomized double-blind, placebo-controlled study. AU - Kudielka,Brigitte M, AU - Fischer,Joachim E, AU - Metzenthin,Petra, AU - Helfricht,Susanne, AU - Preckel,Daniel, AU - von Känel,Roland, Y1 - 2008/02/07/ PY - 2007/06/01/received PY - 2007/11/04/accepted PY - 2008/2/9/pubmed PY - 2008/4/10/medline PY - 2008/2/9/entrez SP - 159 EP - 66 JF - Neuropsychobiology JO - Neuropsychobiology VL - 56 IS - 2-3 N2 - BACKGROUND: The characterization of an individual's hypothalamic-pituitary-adrenal axis stress response is a main research topic in neuropsychobiology since alterations have been causally linked to several disease states. Over the last years, several studies focused on the identification of sources of inter- and intraindividual variability, but there is still a paucity of experimental data on the effect of different pharmaceuticals on cortisol responses to acute psychological stress. Therefore, in this randomized double-blind placebo-controlled study, we investigated the effect of treatment with two popular and clinically used pharmaceuticals on stress-related cortisol responses, namely acetylsalicylic acid (aspirin), a known prostaglandin synthesis inhibitor, and the beta-blocker propranolol (Inderal), a nonselective beta-receptor antagonist. METHODS: For 5 days, 73 healthy subjects (50 men, 23 women; mean age 47.3 +/- 7.7 years) received either a daily oral dose of 100 mg aspirin, 80 mg propranolol (Inderal), aspirin + propranolol, or placebo. After treatment, subjects were confronted with the Trier Social Stress Test, a widely-used standardized psychosocial stress protocol. Cortisol responses were measured by six saliva samples taken before and after the stress exposure. RESULTS: Subjects showed a significant cortisol increase after stress (p < 0.0001). The four treatment groups did not differ in their cortisol responses (group effect p > 0.44; interaction p > 0.97). Additionally, controlling for gender, age, smoking status, body mass index, mean arterial blood pressure or pre-stress cortisol levels yielded similar results in the total sample as well as in the male or female subgroups, respectively. CONCLUSION: Neither short-term treatment with aspirin nor propranolol altered the acute free cortisol response to psychological stress in healthy adults. SN - 1423-0224 UR - https://www.unboundmedicine.com/medline/citation/18259090/No_effect_of_5_day_treatment_with_acetylsalicylic_acid__aspirin__or_the_beta_blocker_propranolol__Inderal__on_free_cortisol_responses_to_acute_psychosocial_stress:_a_randomized_double_blind_placebo_controlled_study_ L2 - https://www.karger.com?DOI=10.1159/000115783 DB - PRIME DP - Unbound Medicine ER -