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Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families.
Psychol Med. 2008 Nov; 38(11):1595-606.PM

Abstract

BACKGROUND

Impairments in executive functioning (EF) and intelligence quotient (IQ) are frequently observed in children with attention deficit hyperactivity disorder (ADHD). The aim of this paper was twofold: first, to examine whether both domains are viable endophenotypic candidates for ADHD and second to investigate whether deficits in both domains tend to co-segregate within families.

METHOD

A large family-based design was used, including 238 ADHD families (545 children) and 147 control families (271 children). Inhibition, visuospatial and verbal working memory, and performance and verbal IQ were analysed.

RESULTS

Children with ADHD, and their affected and non-affected siblings were all impaired on the EF measures and verbal IQ (though unimpaired on performance IQ) and all measures correlated between siblings. Correlations and sibling cross-correlations were not significant between EF and IQ, though they were significant between the measures of one domain. Group differences on EF were not explained by group differences on IQ and vice versa. The discrepancy score between EF and IQ correlated between siblings, indicating that siblings resembled each other in their EF-IQ discrepancy instead of having generalized impairments across both domains. Siblings of probands who had an EF but not IQ impairment, showed a comparable disproportionate lower EF score in relation to IQ score. The opposite pattern was not significant.

CONCLUSIONS

The results supported the viability of EF and IQ as endophenotypic candidates for ADHD. Most findings support an independent familial segregation of both domains. Within EF, similar familial factors influenced inhibition and working memory. Within IQ, similar familial factors influenced verbal and performance IQ.

Authors+Show Affiliations

Department of Clinical Neuropsychology, VU University Amsterdam, Van der Boechorststraat 1, Amsterdam, The Netherlands. nnj.rommelse@psy.vu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18261248

Citation

Rommelse, N N J., et al. "Support for an Independent Familial Segregation of Executive and Intelligence Endophenotypes in ADHD Families." Psychological Medicine, vol. 38, no. 11, 2008, pp. 1595-606.
Rommelse NN, Altink ME, Oosterlaan J, et al. Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families. Psychol Med. 2008;38(11):1595-606.
Rommelse, N. N., Altink, M. E., Oosterlaan, J., Buschgens, C. J., Buitelaar, J., & Sergeant, J. A. (2008). Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families. Psychological Medicine, 38(11), 1595-606. https://doi.org/10.1017/S0033291708002869
Rommelse NN, et al. Support for an Independent Familial Segregation of Executive and Intelligence Endophenotypes in ADHD Families. Psychol Med. 2008;38(11):1595-606. PubMed PMID: 18261248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families. AU - Rommelse,N N J, AU - Altink,M E, AU - Oosterlaan,J, AU - Buschgens,C J M, AU - Buitelaar,J, AU - Sergeant,J A, Y1 - 2008/02/08/ PY - 2008/2/12/pubmed PY - 2009/1/24/medline PY - 2008/2/12/entrez SP - 1595 EP - 606 JF - Psychological medicine JO - Psychol Med VL - 38 IS - 11 N2 - BACKGROUND: Impairments in executive functioning (EF) and intelligence quotient (IQ) are frequently observed in children with attention deficit hyperactivity disorder (ADHD). The aim of this paper was twofold: first, to examine whether both domains are viable endophenotypic candidates for ADHD and second to investigate whether deficits in both domains tend to co-segregate within families. METHOD: A large family-based design was used, including 238 ADHD families (545 children) and 147 control families (271 children). Inhibition, visuospatial and verbal working memory, and performance and verbal IQ were analysed. RESULTS: Children with ADHD, and their affected and non-affected siblings were all impaired on the EF measures and verbal IQ (though unimpaired on performance IQ) and all measures correlated between siblings. Correlations and sibling cross-correlations were not significant between EF and IQ, though they were significant between the measures of one domain. Group differences on EF were not explained by group differences on IQ and vice versa. The discrepancy score between EF and IQ correlated between siblings, indicating that siblings resembled each other in their EF-IQ discrepancy instead of having generalized impairments across both domains. Siblings of probands who had an EF but not IQ impairment, showed a comparable disproportionate lower EF score in relation to IQ score. The opposite pattern was not significant. CONCLUSIONS: The results supported the viability of EF and IQ as endophenotypic candidates for ADHD. Most findings support an independent familial segregation of both domains. Within EF, similar familial factors influenced inhibition and working memory. Within IQ, similar familial factors influenced verbal and performance IQ. SN - 0033-2917 UR - https://www.unboundmedicine.com/medline/citation/18261248/Support_for_an_independent_familial_segregation_of_executive_and_intelligence_endophenotypes_in_ADHD_families_ DB - PRIME DP - Unbound Medicine ER -