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[Relationship between gastrointestinal dyskinesis and gastrointestinal neurons in diabetic mellitus: experiment with rats].
Zhonghua Yi Xue Za Zhi 2007; 87(42):3016-8ZY

Abstract

OBJECTIVE

To investigate the relationship between gastrointestinal dyskinesis and histologic changes of gastrointestinal myenteric plexus cholinergic and nitrergic neurons in STZ-induced diabetic rats.

METHODS

45 SD rats were randomly divided into control group, diabetic group and insulin group. 16 weeks after diabetic model established, gastrointestinal motility of rats was measured and histologic changes of myenteric plexus cholinergic neuron and nitrergic neuron was observed.

RESULTS

Compared with control group, gastrointestinal motility of diabetic group was markedly slow (P < 0.01), the myenteric plexus cholinergic neuron counting of gastric antrum and small intestine were significantly decreased (6.6 +/- 2.9 vs 15.7 +/- 3.8 15.6 +/- 10.3 vs 22.6 +/- 7.4, P < 0.01), yet the number of nitrergic neuron only markedly reduced in gastric antrum (5.3 +/- 1.2 vs 11.8 +/- 2.2, P < 0.01). The gastrointestinal mobility, gastric antrum nitrergic neuron and small intestine cholinergic neuron counting of insulin group were markedly higher than that of diabetic group (P < 0.05), yet lower than that of control group (P < 0.01).

CONCLUSION

The gastrointestinal dyskinesis of STZ-induced diabetic rats might be associated with lesions of gastrointestinal myenteric plexus cholinergic neuron and nitrergic neuron. Insulin intensive therapy can partly ameliorate diabetic gastrointesternal dyskinesis.

Authors+Show Affiliations

Department of Endocrinology, General Hospital, Tianjin Medical College, Tianjin, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18261339

Citation

Hou, Ning-Ning, et al. "[Relationship Between Gastrointestinal Dyskinesis and Gastrointestinal Neurons in Diabetic Mellitus: Experiment With Rats]." Zhonghua Yi Xue Za Zhi, vol. 87, no. 42, 2007, pp. 3016-8.
Hou NN, Wang CX, Luo R, et al. [Relationship between gastrointestinal dyskinesis and gastrointestinal neurons in diabetic mellitus: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2007;87(42):3016-8.
Hou, N. N., Wang, C. X., Luo, R., Jia, H. W., & Qiu, M. C. (2007). [Relationship between gastrointestinal dyskinesis and gastrointestinal neurons in diabetic mellitus: experiment with rats]. Zhonghua Yi Xue Za Zhi, 87(42), pp. 3016-8.
Hou NN, et al. [Relationship Between Gastrointestinal Dyskinesis and Gastrointestinal Neurons in Diabetic Mellitus: Experiment With Rats]. Zhonghua Yi Xue Za Zhi. 2007 Nov 13;87(42):3016-8. PubMed PMID: 18261339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between gastrointestinal dyskinesis and gastrointestinal neurons in diabetic mellitus: experiment with rats]. AU - Hou,Ning-Ning, AU - Wang,Chao-Xun, AU - Luo,Rong, AU - Jia,Hong-Wei, AU - Qiu,Ming-Cai, PY - 2008/2/12/pubmed PY - 2008/7/1/medline PY - 2008/2/12/entrez SP - 3016 EP - 8 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 87 IS - 42 N2 - OBJECTIVE: To investigate the relationship between gastrointestinal dyskinesis and histologic changes of gastrointestinal myenteric plexus cholinergic and nitrergic neurons in STZ-induced diabetic rats. METHODS: 45 SD rats were randomly divided into control group, diabetic group and insulin group. 16 weeks after diabetic model established, gastrointestinal motility of rats was measured and histologic changes of myenteric plexus cholinergic neuron and nitrergic neuron was observed. RESULTS: Compared with control group, gastrointestinal motility of diabetic group was markedly slow (P < 0.01), the myenteric plexus cholinergic neuron counting of gastric antrum and small intestine were significantly decreased (6.6 +/- 2.9 vs 15.7 +/- 3.8 15.6 +/- 10.3 vs 22.6 +/- 7.4, P < 0.01), yet the number of nitrergic neuron only markedly reduced in gastric antrum (5.3 +/- 1.2 vs 11.8 +/- 2.2, P < 0.01). The gastrointestinal mobility, gastric antrum nitrergic neuron and small intestine cholinergic neuron counting of insulin group were markedly higher than that of diabetic group (P < 0.05), yet lower than that of control group (P < 0.01). CONCLUSION: The gastrointestinal dyskinesis of STZ-induced diabetic rats might be associated with lesions of gastrointestinal myenteric plexus cholinergic neuron and nitrergic neuron. Insulin intensive therapy can partly ameliorate diabetic gastrointesternal dyskinesis. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/18261339/[Relationship_between_gastrointestinal_dyskinesis_and_gastrointestinal_neurons_in_diabetic_mellitus:_experiment_with_rats]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2007&amp;vol=87&amp;issue=42&amp;fpage=3016 DB - PRIME DP - Unbound Medicine ER -