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Validity of the ALS-Depression-Inventory (ADI-12)--a new screening instrument for depressive disorders in patients with amyotrophic lateral sclerosis.
J Affect Disord. 2008 Jul; 109(1-2):213-9.JA

Abstract

BACKGROUND

Depressive symptoms among patients with amyotrophic lateral sclerosis (ALS) are usually measured with conventional questionnaires. These measurements do not consider the specific circumstances of the underlying disease. The purpose of this study was to assess the validity of a new short 12 items ALS-Depression-Inventory (ADI-12). We determined convergent, criterion, and concurrent validity. The Structured Clinical Interview (SCID) for DSM-IV was used as the gold standard and the Beck Depression Inventory (BDI) and the WHO Well Being Index (WHO-5) to assess concurrent validity.

METHODS

A total of 39 ALS patients in all stages of the disease were interviewed. Convergent validity was estimated by the inter-correlation between the ADI-12 and the BDI. Criterion and concurrent validity were specified with respect to sensitivity, specificity and predictive values. Receiver Operating Characteristics (ROC) and Areas Under the Curves (AUC) were calculated.

RESULTS

All three depression scales showed excellent internal consistencies (Cronbach's alpha: .8-.9). The correlation between the ADI-12 and the BDI was high (r=.80). For the ADI-12 a cut-off of > or = 30 (SE=100%, SP=83%) identified all patients with a current episode of major depression. A more liberal cut-off (> or = 23) identified all patients with any depressive disorder including minor depression at the cost of specificity (60%).

CONCLUSIONS

With the ADI-12 ALS patients with depressive disorders can be reliably identified. We recommend the ADI-12 for routine screening in primary care of ALS patients.

Authors+Show Affiliations

Department of Medical Psychology and Behavioral Neurobiology, Eberhard-Karls-University Tübingen, 72074 Tübingen, Germany. eva.hammer@uni-tuebingen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

18262283

Citation

Hammer, Eva Maria, et al. "Validity of the ALS-Depression-Inventory (ADI-12)--a New Screening Instrument for Depressive Disorders in Patients With Amyotrophic Lateral Sclerosis." Journal of Affective Disorders, vol. 109, no. 1-2, 2008, pp. 213-9.
Hammer EM, Häcker S, Hautzinger M, et al. Validity of the ALS-Depression-Inventory (ADI-12)--a new screening instrument for depressive disorders in patients with amyotrophic lateral sclerosis. J Affect Disord. 2008;109(1-2):213-9.
Hammer, E. M., Häcker, S., Hautzinger, M., Meyer, T. D., & Kübler, A. (2008). Validity of the ALS-Depression-Inventory (ADI-12)--a new screening instrument for depressive disorders in patients with amyotrophic lateral sclerosis. Journal of Affective Disorders, 109(1-2), 213-9. https://doi.org/10.1016/j.jad.2007.11.012
Hammer EM, et al. Validity of the ALS-Depression-Inventory (ADI-12)--a New Screening Instrument for Depressive Disorders in Patients With Amyotrophic Lateral Sclerosis. J Affect Disord. 2008;109(1-2):213-9. PubMed PMID: 18262283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validity of the ALS-Depression-Inventory (ADI-12)--a new screening instrument for depressive disorders in patients with amyotrophic lateral sclerosis. AU - Hammer,Eva Maria, AU - Häcker,Sonja, AU - Hautzinger,Martin, AU - Meyer,Thomas D, AU - Kübler,Andrea, Y1 - 2008/02/11/ PY - 2007/08/07/received PY - 2007/11/28/revised PY - 2007/11/28/accepted PY - 2008/2/12/pubmed PY - 2008/9/27/medline PY - 2008/2/12/entrez SP - 213 EP - 9 JF - Journal of affective disorders JO - J Affect Disord VL - 109 IS - 1-2 N2 - BACKGROUND: Depressive symptoms among patients with amyotrophic lateral sclerosis (ALS) are usually measured with conventional questionnaires. These measurements do not consider the specific circumstances of the underlying disease. The purpose of this study was to assess the validity of a new short 12 items ALS-Depression-Inventory (ADI-12). We determined convergent, criterion, and concurrent validity. The Structured Clinical Interview (SCID) for DSM-IV was used as the gold standard and the Beck Depression Inventory (BDI) and the WHO Well Being Index (WHO-5) to assess concurrent validity. METHODS: A total of 39 ALS patients in all stages of the disease were interviewed. Convergent validity was estimated by the inter-correlation between the ADI-12 and the BDI. Criterion and concurrent validity were specified with respect to sensitivity, specificity and predictive values. Receiver Operating Characteristics (ROC) and Areas Under the Curves (AUC) were calculated. RESULTS: All three depression scales showed excellent internal consistencies (Cronbach's alpha: .8-.9). The correlation between the ADI-12 and the BDI was high (r=.80). For the ADI-12 a cut-off of > or = 30 (SE=100%, SP=83%) identified all patients with a current episode of major depression. A more liberal cut-off (> or = 23) identified all patients with any depressive disorder including minor depression at the cost of specificity (60%). CONCLUSIONS: With the ADI-12 ALS patients with depressive disorders can be reliably identified. We recommend the ADI-12 for routine screening in primary care of ALS patients. SN - 0165-0327 UR - https://www.unboundmedicine.com/medline/citation/18262283/Validity_of_the_ALS_Depression_Inventory__ADI_12___a_new_screening_instrument_for_depressive_disorders_in_patients_with_amyotrophic_lateral_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(07)00418-1 DB - PRIME DP - Unbound Medicine ER -