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Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-alpha, and C-reactive protein to a high-fat dietary load.
Nutrition. 2008 Apr; 24(4):322-9.N

Abstract

OBJECTIVE

Circulating levels of adiponectin are low in obesity and metabolic disorders associated with increasing fat mass including insulin resistance and dyslipidemia. Body fat stores may be positively related to intake of dietary fat, but little is known of mechanisms by which serum adiponectin may be regulated through diet. We investigated acute effects of a high-fat load and changes in fatty acid saturation on circulating adiponectin and associated mediators of inflammation including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP).

METHODS

A high-fat test meal (59 +/- 4 g fat; 71% of energy as fat) containing a high (approximately 71:29) or low (approximately 55:45) ratio of saturated:unsaturated fatty acids was given at breakfast on two occasions. Blood samples were collected at 0 (baseline), 1, 3, and 6 h for measurement of adiponectin, IL-6, TNF-alpha, and high-sensitivity CRP. A fat-exclusion lunch, snack, and dinner were also given and blood samples collected at 10 and 24 h.

RESULTS

Eighteen healthy, lean men completed the trial. There was no evidence of acute change in circulating adiponectin in response to the lipid bolus or a differential effect of fatty acid saturation on adiponectin, high-sensitivity CRP, or IL-6 (P > 0.05). IL-6 increased over 6 h on both treatments (time, P < 0.05). TNF-alpha decreased on the high saturated:unsaturated fatty acid treatment (treatment by time, P < 0.05). There were no significant correlations between circulating adiponectin and insulin on either dietary treatment in these normoglycemic subjects.

CONCLUSION

Acute changes in the content of saturated and unsaturated fatty acids had no adverse effect on postprandial circulation of the adipose-related factors adiponectin, IL-6, TNF-alpha, or high-sensitivity CRP.

Authors+Show Affiliations

Human Nutrition Unit, University of Auckland, Auckland, New Zealand. s.poppitt@auckland.ac.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18262390

Citation

Poppitt, Sally D., et al. "Postprandial Response of Adiponectin, Interleukin-6, Tumor Necrosis Factor-alpha, and C-reactive Protein to a High-fat Dietary Load." Nutrition (Burbank, Los Angeles County, Calif.), vol. 24, no. 4, 2008, pp. 322-9.
Poppitt SD, Keogh GF, Lithander FE, et al. Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-alpha, and C-reactive protein to a high-fat dietary load. Nutrition. 2008;24(4):322-9.
Poppitt, S. D., Keogh, G. F., Lithander, F. E., Wang, Y., Mulvey, T. B., Chan, Y. K., McArdle, B. H., & Cooper, G. J. (2008). Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-alpha, and C-reactive protein to a high-fat dietary load. Nutrition (Burbank, Los Angeles County, Calif.), 24(4), 322-9. https://doi.org/10.1016/j.nut.2007.12.012
Poppitt SD, et al. Postprandial Response of Adiponectin, Interleukin-6, Tumor Necrosis Factor-alpha, and C-reactive Protein to a High-fat Dietary Load. Nutrition. 2008;24(4):322-9. PubMed PMID: 18262390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-alpha, and C-reactive protein to a high-fat dietary load. AU - Poppitt,Sally D, AU - Keogh,Geraldine F, AU - Lithander,Fiona E, AU - Wang,Yu, AU - Mulvey,Tom B, AU - Chan,Yih-Kai, AU - McArdle,Brian H, AU - Cooper,Garth J S, Y1 - 2008/02/11/ PY - 2007/07/21/received PY - 2007/11/05/revised PY - 2007/12/18/accepted PY - 2008/2/12/pubmed PY - 2008/7/1/medline PY - 2008/2/12/entrez SP - 322 EP - 9 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 24 IS - 4 N2 - OBJECTIVE: Circulating levels of adiponectin are low in obesity and metabolic disorders associated with increasing fat mass including insulin resistance and dyslipidemia. Body fat stores may be positively related to intake of dietary fat, but little is known of mechanisms by which serum adiponectin may be regulated through diet. We investigated acute effects of a high-fat load and changes in fatty acid saturation on circulating adiponectin and associated mediators of inflammation including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP). METHODS: A high-fat test meal (59 +/- 4 g fat; 71% of energy as fat) containing a high (approximately 71:29) or low (approximately 55:45) ratio of saturated:unsaturated fatty acids was given at breakfast on two occasions. Blood samples were collected at 0 (baseline), 1, 3, and 6 h for measurement of adiponectin, IL-6, TNF-alpha, and high-sensitivity CRP. A fat-exclusion lunch, snack, and dinner were also given and blood samples collected at 10 and 24 h. RESULTS: Eighteen healthy, lean men completed the trial. There was no evidence of acute change in circulating adiponectin in response to the lipid bolus or a differential effect of fatty acid saturation on adiponectin, high-sensitivity CRP, or IL-6 (P > 0.05). IL-6 increased over 6 h on both treatments (time, P < 0.05). TNF-alpha decreased on the high saturated:unsaturated fatty acid treatment (treatment by time, P < 0.05). There were no significant correlations between circulating adiponectin and insulin on either dietary treatment in these normoglycemic subjects. CONCLUSION: Acute changes in the content of saturated and unsaturated fatty acids had no adverse effect on postprandial circulation of the adipose-related factors adiponectin, IL-6, TNF-alpha, or high-sensitivity CRP. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/18262390/Postprandial_response_of_adiponectin_interleukin_6_tumor_necrosis_factor_alpha_and_C_reactive_protein_to_a_high_fat_dietary_load_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(07)00389-9 DB - PRIME DP - Unbound Medicine ER -