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Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial.

Abstract

This study examined dietary risk factors for incident benign prostatic hyperplasia (BPH) in 4,770 Prostate Cancer Prevention Trial (1994-2003) placebo-arm participants who were free of BPH at baseline. BPH was assessed over 7 years and was defined as medical or surgical treatment or repeated elevation (>14) on the International Prostate Symptom Score questionnaire. Diet, alcohol, and supplement use were assessed by use of a food frequency questionnaire. There were 876 incident BPH cases (33.6/1,000 person-years). The hazard ratios for the contrasts of the highest to lowest quintiles increased 31% for total fat and 27% for polyunsaturated fat and decreased 15% for protein (all p(trend) < 0.05). The risk was significantly lower in high consumers of alcoholic beverages (0 vs. > or =2/day: hazard ratio (HR) = 0.67) and vegetables (<1 vs. > or =4/day: HR = 0.68) and higher in daily (vs. <1/week) consumers of red meat (HR = 1.38). There were no associations of supplemental antioxidants with risk, and there was weak evidence for associations of lycopene, zinc, and supplemental vitamin D with reduced risk. A diet low in fat and red meat and high in protein and vegetables, as well as regular alcohol consumption, may reduce the risk of symptomatic BPH.

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  • Authors+Show Affiliations

    ,

    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. akristal@fhcrc.org

    , , , , ,

    Source

    American journal of epidemiology 167:8 2008 Apr 15 pg 925-34

    MeSH

    Aged
    Aged, 80 and over
    Alcohol Drinking
    Diet
    Dietary Supplements
    Feeding Behavior
    Finasteride
    Humans
    Incidence
    Male
    Middle Aged
    Nutrition Surveys
    Nutritional Status
    Odds Ratio
    Prospective Studies
    Prostatic Hyperplasia
    Prostatic Neoplasms
    Proteins
    Risk Assessment
    Risk Factors
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    18263602

    Citation

    Kristal, Alan R., et al. "Dietary Patterns, Supplement Use, and the Risk of Symptomatic Benign Prostatic Hyperplasia: Results From the Prostate Cancer Prevention Trial." American Journal of Epidemiology, vol. 167, no. 8, 2008, pp. 925-34.
    Kristal AR, Arnold KB, Schenk JM, et al. Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial. Am J Epidemiol. 2008;167(8):925-34.
    Kristal, A. R., Arnold, K. B., Schenk, J. M., Neuhouser, M. L., Goodman, P., Penson, D. F., & Thompson, I. M. (2008). Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial. American Journal of Epidemiology, 167(8), pp. 925-34. doi:10.1093/aje/kwm389.
    Kristal AR, et al. Dietary Patterns, Supplement Use, and the Risk of Symptomatic Benign Prostatic Hyperplasia: Results From the Prostate Cancer Prevention Trial. Am J Epidemiol. 2008 Apr 15;167(8):925-34. PubMed PMID: 18263602.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial. AU - Kristal,Alan R, AU - Arnold,Kathryn B, AU - Schenk,Jeannette M, AU - Neuhouser,Marian L, AU - Goodman,Phyllis, AU - Penson,David F, AU - Thompson,Ian M, Y1 - 2008/02/07/ PY - 2008/2/12/pubmed PY - 2008/5/16/medline PY - 2008/2/12/entrez SP - 925 EP - 34 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 167 IS - 8 N2 - This study examined dietary risk factors for incident benign prostatic hyperplasia (BPH) in 4,770 Prostate Cancer Prevention Trial (1994-2003) placebo-arm participants who were free of BPH at baseline. BPH was assessed over 7 years and was defined as medical or surgical treatment or repeated elevation (>14) on the International Prostate Symptom Score questionnaire. Diet, alcohol, and supplement use were assessed by use of a food frequency questionnaire. There were 876 incident BPH cases (33.6/1,000 person-years). The hazard ratios for the contrasts of the highest to lowest quintiles increased 31% for total fat and 27% for polyunsaturated fat and decreased 15% for protein (all p(trend) < 0.05). The risk was significantly lower in high consumers of alcoholic beverages (0 vs. > or =2/day: hazard ratio (HR) = 0.67) and vegetables (<1 vs. > or =4/day: HR = 0.68) and higher in daily (vs. <1/week) consumers of red meat (HR = 1.38). There were no associations of supplemental antioxidants with risk, and there was weak evidence for associations of lycopene, zinc, and supplemental vitamin D with reduced risk. A diet low in fat and red meat and high in protein and vegetables, as well as regular alcohol consumption, may reduce the risk of symptomatic BPH. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/18263602/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm389 DB - PRIME DP - Unbound Medicine ER -