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Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium.
Blood 2008; 111(8):4029-38Blood

Abstract

Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95% CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lymphomagenesis.

Authors+Show Affiliations

Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, SE-171 76 Stockholm, Sweden. karin.ekstrom.smedby@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18263783

Citation

Ekström Smedby, Karin, et al. "Autoimmune Disorders and Risk of non-Hodgkin Lymphoma Subtypes: a Pooled Analysis Within the InterLymph Consortium." Blood, vol. 111, no. 8, 2008, pp. 4029-38.
Ekström Smedby K, Vajdic CM, Falster M, et al. Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood. 2008;111(8):4029-38.
Ekström Smedby, K., Vajdic, C. M., Falster, M., Engels, E. A., Martínez-Maza, O., Turner, J., ... Cozen, W. (2008). Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood, 111(8), pp. 4029-38. doi:10.1182/blood-2007-10-119974.
Ekström Smedby K, et al. Autoimmune Disorders and Risk of non-Hodgkin Lymphoma Subtypes: a Pooled Analysis Within the InterLymph Consortium. Blood. 2008 Apr 15;111(8):4029-38. PubMed PMID: 18263783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. AU - Ekström Smedby,Karin, AU - Vajdic,Claire M, AU - Falster,Michael, AU - Engels,Eric A, AU - Martínez-Maza,Otoniel, AU - Turner,Jennifer, AU - Hjalgrim,Henrik, AU - Vineis,Paolo, AU - Seniori Costantini,Adele, AU - Bracci,Paige M, AU - Holly,Elizabeth A, AU - Willett,Eleanor, AU - Spinelli,John J, AU - La Vecchia,Carlo, AU - Zheng,Tongzhang, AU - Becker,Nikolaus, AU - De Sanjosé,Silvia, AU - Chiu,Brian C-H, AU - Dal Maso,Luigino, AU - Cocco,Pierluigi, AU - Maynadié,Marc, AU - Foretova,Lenka, AU - Staines,Anthony, AU - Brennan,Paul, AU - Davis,Scott, AU - Severson,Richard, AU - Cerhan,James R, AU - Breen,Elizabeth C, AU - Birmann,Brenda, AU - Grulich,Andrew E, AU - Cozen,Wendy, Y1 - 2008/02/08/ PY - 2008/2/12/pubmed PY - 2008/5/14/medline PY - 2008/2/12/entrez SP - 4029 EP - 38 JF - Blood JO - Blood VL - 111 IS - 8 N2 - Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95% CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lymphomagenesis. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/18263783/full_citation L2 - http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=18263783 DB - PRIME DP - Unbound Medicine ER -