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Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium.

Abstract

Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95% CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lymphomagenesis.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, SE-171 76 Stockholm, Sweden. karin.ekstrom.smedby@ki.se

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    Blood 111:8 2008 Apr 15 pg 4029-38

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Anemia, Hemolytic
    Arthritis, Rheumatoid
    Autoimmune Diseases
    Case-Control Studies
    Celiac Disease
    Cell Lineage
    Demography
    Female
    Humans
    Lupus Erythematosus, Systemic
    Lymphoma, Non-Hodgkin
    Male
    Middle Aged
    Odds Ratio
    Psoriasis
    Risk Factors
    Sjogren's Syndrome

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18263783

    Citation

    Ekström Smedby, Karin, et al. "Autoimmune Disorders and Risk of non-Hodgkin Lymphoma Subtypes: a Pooled Analysis Within the InterLymph Consortium." Blood, vol. 111, no. 8, 2008, pp. 4029-38.
    Ekström Smedby K, Vajdic CM, Falster M, et al. Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood. 2008;111(8):4029-38.
    Ekström Smedby, K., Vajdic, C. M., Falster, M., Engels, E. A., Martínez-Maza, O., Turner, J., ... Cozen, W. (2008). Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood, 111(8), pp. 4029-38. doi:10.1182/blood-2007-10-119974.
    Ekström Smedby K, et al. Autoimmune Disorders and Risk of non-Hodgkin Lymphoma Subtypes: a Pooled Analysis Within the InterLymph Consortium. Blood. 2008 Apr 15;111(8):4029-38. PubMed PMID: 18263783.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. AU - Ekström Smedby,Karin, AU - Vajdic,Claire M, AU - Falster,Michael, AU - Engels,Eric A, AU - Martínez-Maza,Otoniel, AU - Turner,Jennifer, AU - Hjalgrim,Henrik, AU - Vineis,Paolo, AU - Seniori Costantini,Adele, AU - Bracci,Paige M, AU - Holly,Elizabeth A, AU - Willett,Eleanor, AU - Spinelli,John J, AU - La Vecchia,Carlo, AU - Zheng,Tongzhang, AU - Becker,Nikolaus, AU - De Sanjosé,Silvia, AU - Chiu,Brian C-H, AU - Dal Maso,Luigino, AU - Cocco,Pierluigi, AU - Maynadié,Marc, AU - Foretova,Lenka, AU - Staines,Anthony, AU - Brennan,Paul, AU - Davis,Scott, AU - Severson,Richard, AU - Cerhan,James R, AU - Breen,Elizabeth C, AU - Birmann,Brenda, AU - Grulich,Andrew E, AU - Cozen,Wendy, Y1 - 2008/02/08/ PY - 2008/2/12/pubmed PY - 2008/5/14/medline PY - 2008/2/12/entrez SP - 4029 EP - 38 JF - Blood JO - Blood VL - 111 IS - 8 N2 - Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95% CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lymphomagenesis. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/18263783/full_citation L2 - http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=18263783 DB - PRIME DP - Unbound Medicine ER -