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Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease.
Acta Neuropathol. 2008 Apr; 115(4):437-44.AN

Abstract

Lewy bodies, the histologic hallmark of Parkinson's disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology.

Authors+Show Affiliations

Neuropathology Laboratory, Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. dickson.dennis@mayo.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18264713

Citation

Dickson, Dennis W., et al. "Evidence That Incidental Lewy Body Disease Is Pre-symptomatic Parkinson's Disease." Acta Neuropathologica, vol. 115, no. 4, 2008, pp. 437-44.
Dickson DW, Fujishiro H, DelleDonne A, et al. Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease. Acta Neuropathol. 2008;115(4):437-44.
Dickson, D. W., Fujishiro, H., DelleDonne, A., Menke, J., Ahmed, Z., Klos, K. J., Josephs, K. A., Frigerio, R., Burnett, M., Parisi, J. E., & Ahlskog, J. E. (2008). Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease. Acta Neuropathologica, 115(4), 437-44. https://doi.org/10.1007/s00401-008-0345-7
Dickson DW, et al. Evidence That Incidental Lewy Body Disease Is Pre-symptomatic Parkinson's Disease. Acta Neuropathol. 2008;115(4):437-44. PubMed PMID: 18264713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease. AU - Dickson,Dennis W, AU - Fujishiro,Hiroshige, AU - DelleDonne,Anthony, AU - Menke,Joshua, AU - Ahmed,Zeshan, AU - Klos,Kevin J, AU - Josephs,Keith A, AU - Frigerio,Roberta, AU - Burnett,Melinda, AU - Parisi,Joseph E, AU - Ahlskog,J Eric, Y1 - 2008/02/09/ PY - 2007/12/06/received PY - 2008/01/24/accepted PY - 2008/01/23/revised PY - 2008/2/12/pubmed PY - 2008/8/2/medline PY - 2008/2/12/entrez SP - 437 EP - 44 JF - Acta neuropathologica JO - Acta Neuropathol VL - 115 IS - 4 N2 - Lewy bodies, the histologic hallmark of Parkinson's disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/18264713/Evidence_that_incidental_Lewy_body_disease_is_pre_symptomatic_Parkinson's_disease_ L2 - https://dx.doi.org/10.1007/s00401-008-0345-7 DB - PRIME DP - Unbound Medicine ER -