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Follicular mucinosis: histopathologic review of 33 cases.
Mayo Clin Proc. 1991 Apr; 66(4):387-90.MC

Abstract

Among 33 patients with the histologic diagnosis of follicular mucinosis (alopecia mucinosa) made at our institution between 1982 and 1989, 9 had mycosis fungoides diagnosed concomitantly. Three other patients had lymphoproliferative disorders, and two had Kaposi's sarcoma. Analysis of biopsy features such as epidermal lymphocytic exocytosis, periappendageal infiltrate, and deposition of mucin revealed no predominant finding that distinguished a benign course from mycosis fungoides. A predominance of eosinophils in the infiltrate was suggestive of benign follicular mucinosis rather than mycosis fungoides. Gene rearrangement studies detected three clones in three patients with follicular mucinosis; two were in patients with mycosis fungoides, and one was in a patient with dermatitis. The outcome of these three patients is pending further follow-up. No histopathologic or clinical features distinguished these patients from the others.

Authors+Show Affiliations

Department of Dermatology, Mayo Clinic, Rochester 55905.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1826537

Citation

Mehregan, D A., et al. "Follicular Mucinosis: Histopathologic Review of 33 Cases." Mayo Clinic Proceedings, vol. 66, no. 4, 1991, pp. 387-90.
Mehregan DA, Gibson LE, Muller SA. Follicular mucinosis: histopathologic review of 33 cases. Mayo Clin Proc. 1991;66(4):387-90.
Mehregan, D. A., Gibson, L. E., & Muller, S. A. (1991). Follicular mucinosis: histopathologic review of 33 cases. Mayo Clinic Proceedings, 66(4), 387-90.
Mehregan DA, Gibson LE, Muller SA. Follicular Mucinosis: Histopathologic Review of 33 Cases. Mayo Clin Proc. 1991;66(4):387-90. PubMed PMID: 1826537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Follicular mucinosis: histopathologic review of 33 cases. AU - Mehregan,D A, AU - Gibson,L E, AU - Muller,S A, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 387 EP - 90 JF - Mayo Clinic proceedings JO - Mayo Clin Proc VL - 66 IS - 4 N2 - Among 33 patients with the histologic diagnosis of follicular mucinosis (alopecia mucinosa) made at our institution between 1982 and 1989, 9 had mycosis fungoides diagnosed concomitantly. Three other patients had lymphoproliferative disorders, and two had Kaposi's sarcoma. Analysis of biopsy features such as epidermal lymphocytic exocytosis, periappendageal infiltrate, and deposition of mucin revealed no predominant finding that distinguished a benign course from mycosis fungoides. A predominance of eosinophils in the infiltrate was suggestive of benign follicular mucinosis rather than mycosis fungoides. Gene rearrangement studies detected three clones in three patients with follicular mucinosis; two were in patients with mycosis fungoides, and one was in a patient with dermatitis. The outcome of these three patients is pending further follow-up. No histopathologic or clinical features distinguished these patients from the others. SN - 0025-6196 UR - https://www.unboundmedicine.com/medline/citation/1826537/Follicular_mucinosis:_histopathologic_review_of_33_cases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(12)60662-4 DB - PRIME DP - Unbound Medicine ER -