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Cytotoxic lupane-, secolupane-, and oleanane-type triterpenes from Viburnum awabuki.
Nat Prod Res. 2008 Feb 15; 22(3):191-7.NP

Abstract

Bioassay-guided fractionation of the methanolic extract of Viburnum awabuki afforded two new lupane triterpene derivatives; 6 beta-hydroxyl-3,20-dioxo-30 norlupane-28-oic acid (1) and 3,4-secolup-4,20-dihydroxy-3,28-dioic acid-3-oic acid methyl ester (2), along with seven known lupane and oleanane-type triterpenes (3-9). The structure of the isolated compounds was assigned using different spectroscopic techniques including 1D and 2D NMR. The 13CNMR data of compounds 5 and 9 is reported for the first time. Triterpenes 1, 2, and 7-9 showed in vitro cytotoxic activity against several tumor cell lines.

Authors+Show Affiliations

Faculty of Pharmacy, Department of Pharmacognosy, Mansoura University, Mansoura 35516, Egypt. aelgamal00@yahoo.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18266145

Citation

El-Gamal, Ali A.. "Cytotoxic Lupane-, Secolupane-, and Oleanane-type Triterpenes From Viburnum Awabuki." Natural Product Research, vol. 22, no. 3, 2008, pp. 191-7.
El-Gamal AA. Cytotoxic lupane-, secolupane-, and oleanane-type triterpenes from Viburnum awabuki. Nat Prod Res. 2008;22(3):191-7.
El-Gamal, A. A. (2008). Cytotoxic lupane-, secolupane-, and oleanane-type triterpenes from Viburnum awabuki. Natural Product Research, 22(3), 191-7. https://doi.org/10.1080/14786410701761019
El-Gamal AA. Cytotoxic Lupane-, Secolupane-, and Oleanane-type Triterpenes From Viburnum Awabuki. Nat Prod Res. 2008 Feb 15;22(3):191-7. PubMed PMID: 18266145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic lupane-, secolupane-, and oleanane-type triterpenes from Viburnum awabuki. A1 - El-Gamal,Ali A, PY - 2008/2/13/pubmed PY - 2008/5/21/medline PY - 2008/2/13/entrez SP - 191 EP - 7 JF - Natural product research JO - Nat Prod Res VL - 22 IS - 3 N2 - Bioassay-guided fractionation of the methanolic extract of Viburnum awabuki afforded two new lupane triterpene derivatives; 6 beta-hydroxyl-3,20-dioxo-30 norlupane-28-oic acid (1) and 3,4-secolup-4,20-dihydroxy-3,28-dioic acid-3-oic acid methyl ester (2), along with seven known lupane and oleanane-type triterpenes (3-9). The structure of the isolated compounds was assigned using different spectroscopic techniques including 1D and 2D NMR. The 13CNMR data of compounds 5 and 9 is reported for the first time. Triterpenes 1, 2, and 7-9 showed in vitro cytotoxic activity against several tumor cell lines. SN - 1478-6419 UR - https://www.unboundmedicine.com/medline/citation/18266145/Cytotoxic_lupane__secolupane__and_oleanane_type_triterpenes_from_Viburnum_awabuki_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786410701761019 DB - PRIME DP - Unbound Medicine ER -