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Inadequate energy and excess protein intakes may be associated with worsening renal function in chronic kidney disease.
J Ren Nutr. 2008 Mar; 18(2):187-94.JR

Abstract

OBJECTIVES

Dietary energy and protein play important roles in chronic kidney disease (CKD). This study investigates the relationship between energy/protein intake status and renal function in CKD.

DESIGN AND STUDY POPULATION

This cross-sectional study included 599 adult patients diagnosed with stage 3 to 5 CKD in nephrology and nutrition outpatient clinics in Taiwan.

MAIN OUTCOME MEASURE

Energy and protein intakes were assessed using 24-h dietary recall. We recorded recommended calorie/protein amounts and renal function indices, glomerular filtration rate (GFR), creatinine, and blood urea nitrogen (BUN). Patients were categorized into three intake calorie/protein groups by a ratio of actual intake vs. recommended intake. High intake was defined as a ratio of actual intake/recommended intake > or = 110%, moderate intake as > or = 90% to <110%, and low intake as <90%. Data were analyzed by paired t test, one-way analysis of variance, least significant differences, and multiple linear regression.

RESULTS

The energy and protein intakes in CKD patients were significantly higher and lower than recommended levels (P < .001). Low energy intake was significantly related to worsening GFR at increments of -4.41 mL/min/1.73 m(2), compared with moderate and high energy intake (P = .008); high protein intake was also associated with worsening GFR at increments of -3.50 mL/min/1.73m(2), compared with moderate and low protein intake (P < .001). Low energy intake and high protein intake were significantly positively correlated with elevations in creatinine and BUN.

CONCLUSION

Lower energy and higher protein intakes than recommended may be associated with deteriorating renal function.

Authors+Show Affiliations

Department of Nutrition, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18267211

Citation

Huang, Meng-Chuan, et al. "Inadequate Energy and Excess Protein Intakes May Be Associated With Worsening Renal Function in Chronic Kidney Disease." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 18, no. 2, 2008, pp. 187-94.
Huang MC, Chen ME, Hung HC, et al. Inadequate energy and excess protein intakes may be associated with worsening renal function in chronic kidney disease. J Ren Nutr. 2008;18(2):187-94.
Huang, M. C., Chen, M. E., Hung, H. C., Chen, H. C., Chang, W. T., Lee, C. H., Wu, Y. Y., Chiang, H. C., & Hwang, S. J. (2008). Inadequate energy and excess protein intakes may be associated with worsening renal function in chronic kidney disease. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 18(2), 187-94. https://doi.org/10.1053/j.jrn.2007.08.003
Huang MC, et al. Inadequate Energy and Excess Protein Intakes May Be Associated With Worsening Renal Function in Chronic Kidney Disease. J Ren Nutr. 2008;18(2):187-94. PubMed PMID: 18267211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inadequate energy and excess protein intakes may be associated with worsening renal function in chronic kidney disease. AU - Huang,Meng-Chuan, AU - Chen,Mei-En, AU - Hung,Hsin-Chia, AU - Chen,Hung-Chun, AU - Chang,Wen-Tsan, AU - Lee,Chien-Hung, AU - Wu,Yueh-Ying, AU - Chiang,Hung-Che, AU - Hwang,Shang-Jyh, PY - 2007/05/13/received PY - 2008/2/13/pubmed PY - 2008/3/18/medline PY - 2008/2/13/entrez SP - 187 EP - 94 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 18 IS - 2 N2 - OBJECTIVES: Dietary energy and protein play important roles in chronic kidney disease (CKD). This study investigates the relationship between energy/protein intake status and renal function in CKD. DESIGN AND STUDY POPULATION: This cross-sectional study included 599 adult patients diagnosed with stage 3 to 5 CKD in nephrology and nutrition outpatient clinics in Taiwan. MAIN OUTCOME MEASURE: Energy and protein intakes were assessed using 24-h dietary recall. We recorded recommended calorie/protein amounts and renal function indices, glomerular filtration rate (GFR), creatinine, and blood urea nitrogen (BUN). Patients were categorized into three intake calorie/protein groups by a ratio of actual intake vs. recommended intake. High intake was defined as a ratio of actual intake/recommended intake > or = 110%, moderate intake as > or = 90% to <110%, and low intake as <90%. Data were analyzed by paired t test, one-way analysis of variance, least significant differences, and multiple linear regression. RESULTS: The energy and protein intakes in CKD patients were significantly higher and lower than recommended levels (P < .001). Low energy intake was significantly related to worsening GFR at increments of -4.41 mL/min/1.73 m(2), compared with moderate and high energy intake (P = .008); high protein intake was also associated with worsening GFR at increments of -3.50 mL/min/1.73m(2), compared with moderate and low protein intake (P < .001). Low energy intake and high protein intake were significantly positively correlated with elevations in creatinine and BUN. CONCLUSION: Lower energy and higher protein intakes than recommended may be associated with deteriorating renal function. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/18267211/Inadequate_energy_and_excess_protein_intakes_may_be_associated_with_worsening_renal_function_in_chronic_kidney_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(07)00183-5 DB - PRIME DP - Unbound Medicine ER -