Tags

Type your tag names separated by a space and hit enter

Ninety-day mortality and major complications are not affected by use of lung allocation score.
J Heart Lung Transplant 2008; 27(2):192-6JH

Abstract

BACKGROUND

In May 2005 the Organ Procurement Transplant Network (OPTN) and United Network for Organ Sharing (UNOS) implemented the donor lung allocation score (LAS) system to prioritize organ allocation among prospective transplant recipients. The purpose of our study was to determine the impact of LAS implementation on 90-day survival, early complications and incidence of severe primary graft dysfunction (PGD) after the transplant procedure.

METHODS

Early outcomes among 78 patients receiving transplants after the initiation of the scoring system were compared with those of the 78 previous patients. Survival rates at 90 days and 1 year were the primary end-points of the study. Arterial blood-gas measurements were collected for all patients at the time of ICU arrival and at 12, 24 and 48 hours after surgery to determine the distribution of International Society of Heart and Lung Transplant (ISHLT) PGD grade. Major complications within 30 days post-transplant were recorded.

RESULTS

We found a small but significant 1-year survival advantage among post-LAS implementation patients, which was largely due to decreased early mortality in comparison to the control cohort. The incidence of ISHLT Grade 3 PGD measured within the first 24 hours after transplant did not differ between groups, nor was there an increase in the rate of major post-operative complications.

CONCLUSIONS

Implementation of the LAS system has not been associated with an increase in early mortality, immediate PGD or major complications.

Authors+Show Affiliations

Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18267226

Citation

McCue, Jonathan D., et al. "Ninety-day Mortality and Major Complications Are Not Affected By Use of Lung Allocation Score." The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation, vol. 27, no. 2, 2008, pp. 192-6.
McCue JD, Mooney J, Quail J, et al. Ninety-day mortality and major complications are not affected by use of lung allocation score. J Heart Lung Transplant. 2008;27(2):192-6.
McCue, J. D., Mooney, J., Quail, J., Arrington, A., Herrington, C., & Dahlberg, P. S. (2008). Ninety-day mortality and major complications are not affected by use of lung allocation score. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation, 27(2), pp. 192-6. doi:10.1016/j.healun.2007.11.001.
McCue JD, et al. Ninety-day Mortality and Major Complications Are Not Affected By Use of Lung Allocation Score. J Heart Lung Transplant. 2008;27(2):192-6. PubMed PMID: 18267226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ninety-day mortality and major complications are not affected by use of lung allocation score. AU - McCue,Jonathan D, AU - Mooney,Josh, AU - Quail,Jacob, AU - Arrington,Amanda, AU - Herrington,Cynthia, AU - Dahlberg,Peter S, PY - 2007/08/02/received PY - 2007/10/31/revised PY - 2007/11/02/accepted PY - 2008/2/13/pubmed PY - 2008/3/28/medline PY - 2008/2/13/entrez SP - 192 EP - 6 JF - The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation JO - J. Heart Lung Transplant. VL - 27 IS - 2 N2 - BACKGROUND: In May 2005 the Organ Procurement Transplant Network (OPTN) and United Network for Organ Sharing (UNOS) implemented the donor lung allocation score (LAS) system to prioritize organ allocation among prospective transplant recipients. The purpose of our study was to determine the impact of LAS implementation on 90-day survival, early complications and incidence of severe primary graft dysfunction (PGD) after the transplant procedure. METHODS: Early outcomes among 78 patients receiving transplants after the initiation of the scoring system were compared with those of the 78 previous patients. Survival rates at 90 days and 1 year were the primary end-points of the study. Arterial blood-gas measurements were collected for all patients at the time of ICU arrival and at 12, 24 and 48 hours after surgery to determine the distribution of International Society of Heart and Lung Transplant (ISHLT) PGD grade. Major complications within 30 days post-transplant were recorded. RESULTS: We found a small but significant 1-year survival advantage among post-LAS implementation patients, which was largely due to decreased early mortality in comparison to the control cohort. The incidence of ISHLT Grade 3 PGD measured within the first 24 hours after transplant did not differ between groups, nor was there an increase in the rate of major post-operative complications. CONCLUSIONS: Implementation of the LAS system has not been associated with an increase in early mortality, immediate PGD or major complications. SN - 1557-3117 UR - https://www.unboundmedicine.com/medline/citation/18267226/Ninety_day_mortality_and_major_complications_are_not_affected_by_use_of_lung_allocation_score_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-2498(07)00835-2 DB - PRIME DP - Unbound Medicine ER -