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Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology.
Parkinsonism Relat Disord. 2007; 13 Suppl 3:S221-4.PR

Abstract

Dementia is relatively common in Parkinson's Disease (PD). When dementia occurs in the setting of PD, it is referred to as Parkinson's disease dementia (PDD), which is distinguished from the clinical syndrome in which dementia precedes extrapyramidal features, dementia with Lewy bodies (DLB). In this report, the neuropathology of PDD and DLB is reviewed and preliminary findings are reported on striatal pathology in 28 brains, including 7 PD, 7 PDD and 14 DLB. Sections of putamen immunostained for a-synuclein and investigated with image analysis show that striatal pathology is common and that both cortical and striatal a-synuclein pathology is greater in PDD and DLB than PD. Most cases of PDD and DLB have Alzheimer-type pathology, particularly amyloid plaques, which may act in an additive or synergistic manner with a-synuclein pathology. There are few pathologic differences between PDD and DLB, despite differences in their clinical course.

Authors+Show Affiliations

Fifth Department of Internal Medicine, Fukuoka University, Fukuoka, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18267239

Citation

Tsuboi, Yoshio, et al. "Neuropathology of Parkinson's Disease Dementia and Dementia With Lewy Bodies With Reference to Striatal Pathology." Parkinsonism & Related Disorders, vol. 13 Suppl 3, 2007, pp. S221-4.
Tsuboi Y, Uchikado H, Dickson DW. Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology. Parkinsonism Relat Disord. 2007;13 Suppl 3:S221-4.
Tsuboi, Y., Uchikado, H., & Dickson, D. W. (2007). Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology. Parkinsonism & Related Disorders, 13 Suppl 3, S221-4. https://doi.org/10.1016/S1353-8020(08)70005-1
Tsuboi Y, Uchikado H, Dickson DW. Neuropathology of Parkinson's Disease Dementia and Dementia With Lewy Bodies With Reference to Striatal Pathology. Parkinsonism Relat Disord. 2007;13 Suppl 3:S221-4. PubMed PMID: 18267239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology. AU - Tsuboi,Yoshio, AU - Uchikado,Hirotake, AU - Dickson,Dennis W, PY - 2008/11/19/pubmed PY - 2009/4/2/medline PY - 2008/11/19/entrez SP - S221 EP - 4 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 13 Suppl 3 N2 - Dementia is relatively common in Parkinson's Disease (PD). When dementia occurs in the setting of PD, it is referred to as Parkinson's disease dementia (PDD), which is distinguished from the clinical syndrome in which dementia precedes extrapyramidal features, dementia with Lewy bodies (DLB). In this report, the neuropathology of PDD and DLB is reviewed and preliminary findings are reported on striatal pathology in 28 brains, including 7 PD, 7 PDD and 14 DLB. Sections of putamen immunostained for a-synuclein and investigated with image analysis show that striatal pathology is common and that both cortical and striatal a-synuclein pathology is greater in PDD and DLB than PD. Most cases of PDD and DLB have Alzheimer-type pathology, particularly amyloid plaques, which may act in an additive or synergistic manner with a-synuclein pathology. There are few pathologic differences between PDD and DLB, despite differences in their clinical course. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/18267239/Neuropathology_of_Parkinson's_disease_dementia_and_dementia_with_Lewy_bodies_with_reference_to_striatal_pathology_ DB - PRIME DP - Unbound Medicine ER -