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Gene-environment interactions in Parkinson's disease.
Parkinsonism Relat Disord 2007; 13 Suppl 3:S309-15PR

Abstract

PD is the second most common neurodegenerative disease, and affects 5% of the population by the age of 85. PD is a multi-factorial disease with a complex etiology including genetic risk factors, environmental exposure and aging. The pathogenesis is not fully understood. Here we review research on the genetic and environmental causes of PD and the current research models. None of the single models replicate all the features of PD. Genetic models (possibly including more than one mutation) in combination with toxins or other environmental manipulation may provide better models of PD pathogenesis.

Authors+Show Affiliations

Department of Psychiatry, Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. caross@jhu.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18267256

Citation

Ross, Christopher A., and Wanli W. Smith. "Gene-environment Interactions in Parkinson's Disease." Parkinsonism & Related Disorders, vol. 13 Suppl 3, 2007, pp. S309-15.
Ross CA, Smith WW. Gene-environment interactions in Parkinson's disease. Parkinsonism Relat Disord. 2007;13 Suppl 3:S309-15.
Ross, C. A., & Smith, W. W. (2007). Gene-environment interactions in Parkinson's disease. Parkinsonism & Related Disorders, 13 Suppl 3, pp. S309-15. doi:10.1016/S1353-8020(08)70022-1.
Ross CA, Smith WW. Gene-environment Interactions in Parkinson's Disease. Parkinsonism Relat Disord. 2007;13 Suppl 3:S309-15. PubMed PMID: 18267256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gene-environment interactions in Parkinson's disease. AU - Ross,Christopher A, AU - Smith,Wanli W, PY - 2008/11/19/pubmed PY - 2009/4/2/medline PY - 2008/11/19/entrez SP - S309 EP - 15 JF - Parkinsonism & related disorders JO - Parkinsonism Relat. Disord. VL - 13 Suppl 3 N2 - PD is the second most common neurodegenerative disease, and affects 5% of the population by the age of 85. PD is a multi-factorial disease with a complex etiology including genetic risk factors, environmental exposure and aging. The pathogenesis is not fully understood. Here we review research on the genetic and environmental causes of PD and the current research models. None of the single models replicate all the features of PD. Genetic models (possibly including more than one mutation) in combination with toxins or other environmental manipulation may provide better models of PD pathogenesis. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/18267256/Gene_environment_interactions_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(08)70022-1 DB - PRIME DP - Unbound Medicine ER -