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How to improve neuroprotection in Parkinson's disease?
Parkinsonism Relat Disord. 2007; 13 Suppl 3:S332-5.PR

Abstract

Several factors involved in the etiology of Parkinson's disease (PD) have been proposed, including genetic and environmental factors or even a combination of both. Thus, multiple cellular hits are likely to contribute to neurodegeneration in PD. If such a mechanism happens to occur, our therapeutic intervention may perhaps require a cocktail of molecules acting on various pathways simultaneously. Furthermore, recent evidence suggests that PD may progress even when the initial cause of neurodegeneration has disappeared, suggesting that toxic substances released by the glial cells may be involved in the perpetuation of neuronal degeneration. This may thus represent a therapeutic target for PD.

Authors+Show Affiliations

INSERM U679, Experimental Neurology and Therapeutics, Hôpital de la Salpêtrière, Paris, France. hirsch@crr.jussieu.fr

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18267260

Citation

Hirsch, E C.. "How to Improve Neuroprotection in Parkinson's Disease?" Parkinsonism & Related Disorders, vol. 13 Suppl 3, 2007, pp. S332-5.
Hirsch EC. How to improve neuroprotection in Parkinson's disease? Parkinsonism Relat Disord. 2007;13 Suppl 3:S332-5.
Hirsch, E. C. (2007). How to improve neuroprotection in Parkinson's disease? Parkinsonism & Related Disorders, 13 Suppl 3, S332-5. https://doi.org/10.1016/S1353-8020(08)70026-9
Hirsch EC. How to Improve Neuroprotection in Parkinson's Disease. Parkinsonism Relat Disord. 2007;13 Suppl 3:S332-5. PubMed PMID: 18267260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - How to improve neuroprotection in Parkinson's disease? A1 - Hirsch,E C, PY - 2008/11/19/pubmed PY - 2009/4/2/medline PY - 2008/11/19/entrez SP - S332 EP - 5 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 13 Suppl 3 N2 - Several factors involved in the etiology of Parkinson's disease (PD) have been proposed, including genetic and environmental factors or even a combination of both. Thus, multiple cellular hits are likely to contribute to neurodegeneration in PD. If such a mechanism happens to occur, our therapeutic intervention may perhaps require a cocktail of molecules acting on various pathways simultaneously. Furthermore, recent evidence suggests that PD may progress even when the initial cause of neurodegeneration has disappeared, suggesting that toxic substances released by the glial cells may be involved in the perpetuation of neuronal degeneration. This may thus represent a therapeutic target for PD. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/18267260/How_to_improve_neuroprotection_in_Parkinson's_disease L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(08)70026-9 DB - PRIME DP - Unbound Medicine ER -
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