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Effect of insulin glulisine on microvascular blood flow and endothelial function in the postprandial state.
Diabetes Care. 2008 May; 31(5):1021-5.DC

Abstract

OBJECTIVE

To investigate the effect of insulin glulisine on postprandial microvascular blood flow in type 2 diabetes.

RESEARCH DESIGN AND METHODS

A total of 15 patients with type 2 diabetes received insulin glulisine or human insulin before a liquid meal test. Thereafter, skin microvascular blood flow was measured by laser Doppler fluxmetry and blood samples were taken for measurement of plasma levels of glucose, insulin, intact proinsulin, asymmetric dimethylarginine, nitrotyrosine, interleukin-18, matrix metalloproteinase-9, oxidized LDL, and free fatty acids.

RESULTS

Insulin glulisine injections resulted in higher postprandial insulin levels (means +/- SEM area under the curve [AUC](0-120) 51.0 +/- 6.8 vs. 38.2 +/- 5.4 mU/l; P = 0.004), while plasma glucose (AUC(0-240) 158 +/- 9 vs. 180 +/- 9 mg/dl; P < 0.05) and intact proinsulin (AUC(0-240) 26.2 +/- 3.5 vs. 31.2 +/- 4.3 pmol/l; P = 0.002) were lower. Microvascular blood flow increased after insulin glulisine injection (27.9 +/- 3.1 to 51.7 +/- 9.9 arbitrary units [AU]; P < 0.05), while only a minor increase was found during human insulin (27.9 +/- 3.1 to 34.4 +/- 7.8 AU; not significant). Asymmetric dimethylarginine and nitrotyrosine levels were reduced after insulin glulisine (P < 0.05).

CONCLUSIONS

Insulin glulisine is superior to human insulin in restoring postprandial metabolic and microvascular physiology.

Authors+Show Affiliations

Institute for Clinical Research and Development, Parcusstrasse 8, D-55116 Mainz, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18268067

Citation

Hohberg, Clothilde, et al. "Effect of Insulin Glulisine On Microvascular Blood Flow and Endothelial Function in the Postprandial State." Diabetes Care, vol. 31, no. 5, 2008, pp. 1021-5.
Hohberg C, Forst T, Larbig M, et al. Effect of insulin glulisine on microvascular blood flow and endothelial function in the postprandial state. Diabetes Care. 2008;31(5):1021-5.
Hohberg, C., Forst, T., Larbig, M., Safinowski, M., Diessel, S., Hehenwarter, S., Weber, M. M., Schöndorf, T., & Pfützner, A. (2008). Effect of insulin glulisine on microvascular blood flow and endothelial function in the postprandial state. Diabetes Care, 31(5), 1021-5. https://doi.org/10.2337/dc07-2185
Hohberg C, et al. Effect of Insulin Glulisine On Microvascular Blood Flow and Endothelial Function in the Postprandial State. Diabetes Care. 2008;31(5):1021-5. PubMed PMID: 18268067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of insulin glulisine on microvascular blood flow and endothelial function in the postprandial state. AU - Hohberg,Clothilde, AU - Forst,Thomas, AU - Larbig,Martin, AU - Safinowski,Michael, AU - Diessel,Stefan, AU - Hehenwarter,Silvia, AU - Weber,Matthias M, AU - Schöndorf,Thomas, AU - Pfützner,Andreas, Y1 - 2008/02/11/ PY - 2008/2/13/pubmed PY - 2008/8/7/medline PY - 2008/2/13/entrez SP - 1021 EP - 5 JF - Diabetes care JO - Diabetes Care VL - 31 IS - 5 N2 - OBJECTIVE: To investigate the effect of insulin glulisine on postprandial microvascular blood flow in type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 15 patients with type 2 diabetes received insulin glulisine or human insulin before a liquid meal test. Thereafter, skin microvascular blood flow was measured by laser Doppler fluxmetry and blood samples were taken for measurement of plasma levels of glucose, insulin, intact proinsulin, asymmetric dimethylarginine, nitrotyrosine, interleukin-18, matrix metalloproteinase-9, oxidized LDL, and free fatty acids. RESULTS: Insulin glulisine injections resulted in higher postprandial insulin levels (means +/- SEM area under the curve [AUC](0-120) 51.0 +/- 6.8 vs. 38.2 +/- 5.4 mU/l; P = 0.004), while plasma glucose (AUC(0-240) 158 +/- 9 vs. 180 +/- 9 mg/dl; P < 0.05) and intact proinsulin (AUC(0-240) 26.2 +/- 3.5 vs. 31.2 +/- 4.3 pmol/l; P = 0.002) were lower. Microvascular blood flow increased after insulin glulisine injection (27.9 +/- 3.1 to 51.7 +/- 9.9 arbitrary units [AU]; P < 0.05), while only a minor increase was found during human insulin (27.9 +/- 3.1 to 34.4 +/- 7.8 AU; not significant). Asymmetric dimethylarginine and nitrotyrosine levels were reduced after insulin glulisine (P < 0.05). CONCLUSIONS: Insulin glulisine is superior to human insulin in restoring postprandial metabolic and microvascular physiology. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/18268067/Effect_of_insulin_glulisine_on_microvascular_blood_flow_and_endothelial_function_in_the_postprandial_state_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=18268067 DB - PRIME DP - Unbound Medicine ER -