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Psychosocial outcomes and health-related quality of life in adult childhood cancer survivors: a report from the childhood cancer survivor study.
Cancer Epidemiol Biomarkers Prev. 2008 Feb; 17(2):435-46.CE

Abstract

PURPOSE

Psychological outcomes, health-related quality of life (HRQOL), and life satisfaction are compared between 7,147 adult childhood cancer survivors and 388 siblings from the Childhood Cancer Survivor Study, examining demographic and diagnosis/treatment outcome predictors.

METHODS

Psychological distress, HRQOL, and life satisfaction were measured by the Brief Symptom Inventory-18, the Medical Outcomes Survey Short Form-36, and Cantril Ladder of Life, respectively. A self-report questionnaire provided demographic/health information and medical record abstraction provided cancer/treatment data. Siblings' and survivors' scores were compared using generalized linear mixed models, and predictor effects of demographic and cancer/treatment variables were analyzed by multivariate logistic regression.

RESULTS

Although survivors report greater symptoms of global distress (mean, 49.17; SE, 0.12) than do siblings (mean, 46.64; SE, 0.51), scores remain below population norms, indicating that survivors and siblings remain psychologically healthy. Survivors scored worse than siblings on overall physical (51.30 +/- 0.10 versus 54.98 +/- 0.44; P < 0.001) but not emotional aspects of HRQOL, but effect sizes were small, other than in vitality. Most survivors reported present (mean, 7.3; SD, 0.02) and predicted future (mean, 8.6; SD, 0.02) life satisfaction. Risk factors for psychological distress and poor HRQOL were female gender, lower educational attainment, unmarried status, annual household income <$20,000, unemployment, lack of medical insurance, having a major medical condition, and treatment with cranial radiation.

CONCLUSION

Compared with population norms, childhood cancer survivors and siblings report positive psychological health, good HRQOL, and life satisfaction. The findings identify targeted subgroups of survivors for intervention.

Authors+Show Affiliations

Department of Pediatrics, Division of Cancer Prevention and Control Research, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095-1752, USA. lzeltzer@mednet.ucla.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18268128

Citation

Zeltzer, Lonnie K., et al. "Psychosocial Outcomes and Health-related Quality of Life in Adult Childhood Cancer Survivors: a Report From the Childhood Cancer Survivor Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 2, 2008, pp. 435-46.
Zeltzer LK, Lu Q, Leisenring W, et al. Psychosocial outcomes and health-related quality of life in adult childhood cancer survivors: a report from the childhood cancer survivor study. Cancer Epidemiol Biomarkers Prev. 2008;17(2):435-46.
Zeltzer, L. K., Lu, Q., Leisenring, W., Tsao, J. C., Recklitis, C., Armstrong, G., Mertens, A. C., Robison, L. L., & Ness, K. K. (2008). Psychosocial outcomes and health-related quality of life in adult childhood cancer survivors: a report from the childhood cancer survivor study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(2), 435-46. https://doi.org/10.1158/1055-9965.EPI-07-2541
Zeltzer LK, et al. Psychosocial Outcomes and Health-related Quality of Life in Adult Childhood Cancer Survivors: a Report From the Childhood Cancer Survivor Study. Cancer Epidemiol Biomarkers Prev. 2008;17(2):435-46. PubMed PMID: 18268128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychosocial outcomes and health-related quality of life in adult childhood cancer survivors: a report from the childhood cancer survivor study. AU - Zeltzer,Lonnie K, AU - Lu,Qian, AU - Leisenring,Wendy, AU - Tsao,Jennie C I, AU - Recklitis,Christopher, AU - Armstrong,Gregory, AU - Mertens,Ann C, AU - Robison,Leslie L, AU - Ness,Kirsten K, PY - 2008/2/13/pubmed PY - 2008/5/14/medline PY - 2008/2/13/entrez SP - 435 EP - 46 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 17 IS - 2 N2 - PURPOSE: Psychological outcomes, health-related quality of life (HRQOL), and life satisfaction are compared between 7,147 adult childhood cancer survivors and 388 siblings from the Childhood Cancer Survivor Study, examining demographic and diagnosis/treatment outcome predictors. METHODS: Psychological distress, HRQOL, and life satisfaction were measured by the Brief Symptom Inventory-18, the Medical Outcomes Survey Short Form-36, and Cantril Ladder of Life, respectively. A self-report questionnaire provided demographic/health information and medical record abstraction provided cancer/treatment data. Siblings' and survivors' scores were compared using generalized linear mixed models, and predictor effects of demographic and cancer/treatment variables were analyzed by multivariate logistic regression. RESULTS: Although survivors report greater symptoms of global distress (mean, 49.17; SE, 0.12) than do siblings (mean, 46.64; SE, 0.51), scores remain below population norms, indicating that survivors and siblings remain psychologically healthy. Survivors scored worse than siblings on overall physical (51.30 +/- 0.10 versus 54.98 +/- 0.44; P < 0.001) but not emotional aspects of HRQOL, but effect sizes were small, other than in vitality. Most survivors reported present (mean, 7.3; SD, 0.02) and predicted future (mean, 8.6; SD, 0.02) life satisfaction. Risk factors for psychological distress and poor HRQOL were female gender, lower educational attainment, unmarried status, annual household income <$20,000, unemployment, lack of medical insurance, having a major medical condition, and treatment with cranial radiation. CONCLUSION: Compared with population norms, childhood cancer survivors and siblings report positive psychological health, good HRQOL, and life satisfaction. The findings identify targeted subgroups of survivors for intervention. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/18268128/Psychosocial_outcomes_and_health_related_quality_of_life_in_adult_childhood_cancer_survivors:_a_report_from_the_childhood_cancer_survivor_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=18268128 DB - PRIME DP - Unbound Medicine ER -