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Sensitization and allergy to Cannabis sativa leaves in a population of tomato (Lycopersicon esculentum)-sensitized patients.
Int Arch Allergy Immunol. 2008; 146(3):195-202.IA

Abstract

BACKGROUND

Cases of allergy to Cannabis sativa have occasionally been reported, but both the allergenic profile and eventual cross-reactivity pattern remain unknown.

OBJECTIVE

To analyze the allergenic profile of a population of patients from Spain sensitized to C. sativa and to characterize the C. sativa leaf extract.

METHODS

A total of 32 subjects were enrolled in the study: group A, 10 individuals sensitized to tomato, reporting reactions by contact or inhalation to Cannabis; group B, 14 individuals sensitized to tomato, without reactions to Cannabis; group C, 8 individuals not sensitized to tomato and without reactions to Cannabis. Sensitivity to Cannabis, tomato and peach peel, Platanus hybrida and Artemisia vulgaris pollen extracts was measured by skin tests and specific IgE. Individual immunoblots and inhibition experiments with a pool of sera were conducted.

RESULTS

All tomato-sensitized subjects (and 1 negative) had positive skin tests to C. sativa leaves and hashish. Specific IgE to C. sativa and peach peel was more common than to tomato. Immunoblot experiments showed 2 prominent bands of 10 and 14 kDa and 2 weakly recognized bands of 30 and 45 kDa. Tomato, peach and A. vulgaris extracts inhibited most of the bands present in C. sativa. P. hybrida inhibited only the high-molecular-weight bands.

CONCLUSION

Sensitization to C. sativa with or without symptoms is frequent among patients in Spain sensitized to tomato. C. sativa leaves are a potential allergenic source and their allergens may cross-react with other allergenic sources from plants (fruit peels and pollen).

Authors+Show Affiliations

Unidad de Alergia, Hospital Marina Baixa, Villajoyosa (Alicante) and Centro de Especialidades Foietes, Benidorm, Spain. chernandol@seaic.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18268387

Citation

de Larramendi, Carlos Hernando, et al. "Sensitization and Allergy to Cannabis Sativa Leaves in a Population of Tomato (Lycopersicon Esculentum)-sensitized Patients." International Archives of Allergy and Immunology, vol. 146, no. 3, 2008, pp. 195-202.
de Larramendi CH, Carnés J, García-Abujeta JL, et al. Sensitization and allergy to Cannabis sativa leaves in a population of tomato (Lycopersicon esculentum)-sensitized patients. Int Arch Allergy Immunol. 2008;146(3):195-202.
de Larramendi, C. H., Carnés, J., García-Abujeta, J. L., García-Endrino, A., Muñoz-Palomino, E., Huertas, A. J., Fernández-Caldas, E., & Ferrer, A. (2008). Sensitization and allergy to Cannabis sativa leaves in a population of tomato (Lycopersicon esculentum)-sensitized patients. International Archives of Allergy and Immunology, 146(3), 195-202. https://doi.org/10.1159/000115887
de Larramendi CH, et al. Sensitization and Allergy to Cannabis Sativa Leaves in a Population of Tomato (Lycopersicon Esculentum)-sensitized Patients. Int Arch Allergy Immunol. 2008;146(3):195-202. PubMed PMID: 18268387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitization and allergy to Cannabis sativa leaves in a population of tomato (Lycopersicon esculentum)-sensitized patients. AU - de Larramendi,Carlos Hernando, AU - Carnés,Jerónimo, AU - García-Abujeta,José Luís, AU - García-Endrino,Ana, AU - Muñoz-Palomino,Elena, AU - Huertas,Angel Julio, AU - Fernández-Caldas,Enrique, AU - Ferrer,Angel, Y1 - 2008/02/11/ PY - 2007/07/18/received PY - 2007/10/30/accepted PY - 2008/2/13/pubmed PY - 2008/7/9/medline PY - 2008/2/13/entrez SP - 195 EP - 202 JF - International archives of allergy and immunology JO - Int Arch Allergy Immunol VL - 146 IS - 3 N2 - BACKGROUND: Cases of allergy to Cannabis sativa have occasionally been reported, but both the allergenic profile and eventual cross-reactivity pattern remain unknown. OBJECTIVE: To analyze the allergenic profile of a population of patients from Spain sensitized to C. sativa and to characterize the C. sativa leaf extract. METHODS: A total of 32 subjects were enrolled in the study: group A, 10 individuals sensitized to tomato, reporting reactions by contact or inhalation to Cannabis; group B, 14 individuals sensitized to tomato, without reactions to Cannabis; group C, 8 individuals not sensitized to tomato and without reactions to Cannabis. Sensitivity to Cannabis, tomato and peach peel, Platanus hybrida and Artemisia vulgaris pollen extracts was measured by skin tests and specific IgE. Individual immunoblots and inhibition experiments with a pool of sera were conducted. RESULTS: All tomato-sensitized subjects (and 1 negative) had positive skin tests to C. sativa leaves and hashish. Specific IgE to C. sativa and peach peel was more common than to tomato. Immunoblot experiments showed 2 prominent bands of 10 and 14 kDa and 2 weakly recognized bands of 30 and 45 kDa. Tomato, peach and A. vulgaris extracts inhibited most of the bands present in C. sativa. P. hybrida inhibited only the high-molecular-weight bands. CONCLUSION: Sensitization to C. sativa with or without symptoms is frequent among patients in Spain sensitized to tomato. C. sativa leaves are a potential allergenic source and their allergens may cross-react with other allergenic sources from plants (fruit peels and pollen). SN - 1423-0097 UR - https://www.unboundmedicine.com/medline/citation/18268387/Sensitization_and_allergy_to_Cannabis_sativa_leaves_in_a_population_of_tomato__Lycopersicon_esculentum__sensitized_patients_ L2 - https://www.karger.com?DOI=10.1159/000115887 DB - PRIME DP - Unbound Medicine ER -