Tags

Type your tag names separated by a space and hit enter

Coeliac disease and risk of sepsis.
Gut 2008; 57(8):1074-80Gut

Abstract

OBJECTIVE

To examine the risk of subsequent sepsis in individuals with coeliac disease.

DESIGN

We used Swedish national health registers to identify 15 325 individuals with a diagnosis of coeliac disease (1964-2003) and 14 494 inpatient reference individuals. Cox regression estimated the hazard ratios (HRs) for subsequent sepsis.

RESULTS

Compared with inpatient reference individuals, individuals with coeliac disease were at increased risk of sepsis (HR = 1.6, 95% confidence interval (95% CI) = 1.2 to 1.9, p<0.001). The highest risk estimates were seen for pneumococcal sepsis (HR = 2.5, 95% CI = 1.2 to 5.1, p = 0.014). Individuals with coeliac disease diagnosed in childhood were not at increased risk of subsequent sepsis (HR = 1.0, 95% CI = 0.6 to 1.9, p = 0.908). When individuals with coeliac disease were compared with reference individuals from the general population, coeliac disease was associated with an increased risk of sepsis (HR = 2.6, 95% CI = 2.1 to 3.0, p<0.001). The HR for pneumococcal sepsis was 3.9 (95% CI = 2.2 to 7.0, p<0.001). In this comparison, children with coeliac disease were also at an increased risk of sepsis (HR = 1.8, 95% CI = 1.2 to 2.7, p = 0.003).

CONCLUSION

This study showed a modestly increased risk of sepsis in patients with coeliac disease with the highest risk for pneumococcal sepsis. This risk increase was limited to those with coeliac disease diagnosed in adulthood. Potential explanations include hyposplenism, increased mucosal permeability and an altered composition of the intestinal glycocalyx in individuals with coeliac disease.

Authors+Show Affiliations

Department of Paediatrics, Orebro University Hospital, Sweden. jonasludvigsson@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18270242

Citation

Ludvigsson, J F., et al. "Coeliac Disease and Risk of Sepsis." Gut, vol. 57, no. 8, 2008, pp. 1074-80.
Ludvigsson JF, Olén O, Bell M, et al. Coeliac disease and risk of sepsis. Gut. 2008;57(8):1074-80.
Ludvigsson, J. F., Olén, O., Bell, M., Ekbom, A., & Montgomery, S. M. (2008). Coeliac disease and risk of sepsis. Gut, 57(8), pp. 1074-80. doi:10.1136/gut.2007.133868.
Ludvigsson JF, et al. Coeliac Disease and Risk of Sepsis. Gut. 2008;57(8):1074-80. PubMed PMID: 18270242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coeliac disease and risk of sepsis. AU - Ludvigsson,J F, AU - Olén,O, AU - Bell,M, AU - Ekbom,A, AU - Montgomery,S M, Y1 - 2008/02/12/ PY - 2008/2/14/pubmed PY - 2008/8/9/medline PY - 2008/2/14/entrez SP - 1074 EP - 80 JF - Gut JO - Gut VL - 57 IS - 8 N2 - OBJECTIVE: To examine the risk of subsequent sepsis in individuals with coeliac disease. DESIGN: We used Swedish national health registers to identify 15 325 individuals with a diagnosis of coeliac disease (1964-2003) and 14 494 inpatient reference individuals. Cox regression estimated the hazard ratios (HRs) for subsequent sepsis. RESULTS: Compared with inpatient reference individuals, individuals with coeliac disease were at increased risk of sepsis (HR = 1.6, 95% confidence interval (95% CI) = 1.2 to 1.9, p<0.001). The highest risk estimates were seen for pneumococcal sepsis (HR = 2.5, 95% CI = 1.2 to 5.1, p = 0.014). Individuals with coeliac disease diagnosed in childhood were not at increased risk of subsequent sepsis (HR = 1.0, 95% CI = 0.6 to 1.9, p = 0.908). When individuals with coeliac disease were compared with reference individuals from the general population, coeliac disease was associated with an increased risk of sepsis (HR = 2.6, 95% CI = 2.1 to 3.0, p<0.001). The HR for pneumococcal sepsis was 3.9 (95% CI = 2.2 to 7.0, p<0.001). In this comparison, children with coeliac disease were also at an increased risk of sepsis (HR = 1.8, 95% CI = 1.2 to 2.7, p = 0.003). CONCLUSION: This study showed a modestly increased risk of sepsis in patients with coeliac disease with the highest risk for pneumococcal sepsis. This risk increase was limited to those with coeliac disease diagnosed in adulthood. Potential explanations include hyposplenism, increased mucosal permeability and an altered composition of the intestinal glycocalyx in individuals with coeliac disease. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/18270242/Coeliac_disease_and_risk_of_sepsis_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&amp;pmid=18270242 DB - PRIME DP - Unbound Medicine ER -