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Folate, vitamin B6, vitamin B12, and methionine intakes and risk of stroke subtypes in male smokers.
Am J Epidemiol 2008; 167(8):954-61AJ

Abstract

The associations of dietary folate, vitamin B(6), vitamin B(12), and methionine intakes with risk of stroke subtypes were examined among 26,556 male Finnish smokers, aged 50-69 years, enrolled in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Dietary intake was assessed at baseline by using a validated food frequency questionnaire. During a mean follow-up of 13.6 years, from 1985 through 2004, 2,702 cerebral infarctions, 383 intracerebral hemorrhages, and 196 subarachnoid hemorrhages were identified from national registers. In analyses adjusting for age and cardiovascular risk factors, a high folate intake was associated with a statistically significant lower risk of cerebral infarction but not intracerebral or subarachnoid hemorrhages. The multivariate relative risk of cerebral infarction was 0.80 (95% confidence interval: 0.70, 0.91; p(trend) = 0.001) for men in the highest versus lowest quintile of folate intake. Vitamin B(6), vitamin B(12), and methionine intakes were not significantly associated with any subtype of stroke. These findings in men suggest that a high dietary folate intake may reduce the risk of cerebral infarction.

Authors+Show Affiliations

National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.se

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18270369

Citation

Larsson, Susanna C., et al. "Folate, Vitamin B6, Vitamin B12, and Methionine Intakes and Risk of Stroke Subtypes in Male Smokers." American Journal of Epidemiology, vol. 167, no. 8, 2008, pp. 954-61.
Larsson SC, Männistö S, Virtanen MJ, et al. Folate, vitamin B6, vitamin B12, and methionine intakes and risk of stroke subtypes in male smokers. Am J Epidemiol. 2008;167(8):954-61.
Larsson, S. C., Männistö, S., Virtanen, M. J., Kontto, J., Albanes, D., & Virtamo, J. (2008). Folate, vitamin B6, vitamin B12, and methionine intakes and risk of stroke subtypes in male smokers. American Journal of Epidemiology, 167(8), pp. 954-61. doi:10.1093/aje/kwm395.
Larsson SC, et al. Folate, Vitamin B6, Vitamin B12, and Methionine Intakes and Risk of Stroke Subtypes in Male Smokers. Am J Epidemiol. 2008 Apr 15;167(8):954-61. PubMed PMID: 18270369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate, vitamin B6, vitamin B12, and methionine intakes and risk of stroke subtypes in male smokers. AU - Larsson,Susanna C, AU - Männistö,Satu, AU - Virtanen,Mikko J, AU - Kontto,Jukka, AU - Albanes,Demetrius, AU - Virtamo,Jarmo, Y1 - 2008/02/12/ PY - 2008/2/14/pubmed PY - 2008/5/16/medline PY - 2008/2/14/entrez SP - 954 EP - 61 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 167 IS - 8 N2 - The associations of dietary folate, vitamin B(6), vitamin B(12), and methionine intakes with risk of stroke subtypes were examined among 26,556 male Finnish smokers, aged 50-69 years, enrolled in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Dietary intake was assessed at baseline by using a validated food frequency questionnaire. During a mean follow-up of 13.6 years, from 1985 through 2004, 2,702 cerebral infarctions, 383 intracerebral hemorrhages, and 196 subarachnoid hemorrhages were identified from national registers. In analyses adjusting for age and cardiovascular risk factors, a high folate intake was associated with a statistically significant lower risk of cerebral infarction but not intracerebral or subarachnoid hemorrhages. The multivariate relative risk of cerebral infarction was 0.80 (95% confidence interval: 0.70, 0.91; p(trend) = 0.001) for men in the highest versus lowest quintile of folate intake. Vitamin B(6), vitamin B(12), and methionine intakes were not significantly associated with any subtype of stroke. These findings in men suggest that a high dietary folate intake may reduce the risk of cerebral infarction. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/18270369/Folate_vitamin_B6_vitamin_B12_and_methionine_intakes_and_risk_of_stroke_subtypes_in_male_smokers_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm395 DB - PRIME DP - Unbound Medicine ER -