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Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health Cohort.

Abstract

Obesity and lack of physical activity have been inconsistently associated with pancreatic cancer. Using data from a self-administered baseline questionnaire (1995-1996), the authors investigated the association between adiposity and physical activity and pancreatic cancer in 495,035 participants of the National Institutes of Health-AARP Diet and Health Study who were aged 50-71 years. To avoid the influence of subclinical disease, follow-up time started 1 year after baseline, and subjects with a body mass index (BMI) of <18.5 kg/m(2) were excluded. A subcohort (n = 302,060) completed a second questionnaire with information about physical activity and waist and hip circumference. During follow-up though 2000, 654 pancreatic cancer cases were identified. The authors used Cox proportional hazard models to generate adjusted hazard ratios and 95% confidence intervals. Compared with those with a BMI of 18.5-<25, those with a BMI of >/=35 had a 45% greater pancreatic cancer risk (95% confidence interval (CI): 1.04, 2.02; p(trend) = 0.02). Significant positive associations for BMI were observed among nonsmokers (for BMI > or =35: hazard ratio = 1.70, 95% CI: 1.14, 2.53; p(trend) = 0.004) but not recent smokers (p(interaction) = 0.08). Waist circumference was positively associated with pancreatic cancer (fourth vs. first quartile: hazard ratio = 2.53, 95% CI: 1.13, 5.65; p(trend) = 0.04) in women but not men. The authors observed no association with physical activity. Their results suggest a positive association between adiposity and pancreatic cancer.

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  • Authors+Show Affiliations

    ,

    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA. rs221z@nih.gov

    , , , , , ,

    Source

    American journal of epidemiology 167:5 2008 Mar 01 pg 586-97

    MeSH

    Adiposity
    Age Factors
    Aged
    Body Mass Index
    Diet
    Female
    Humans
    Male
    Middle Aged
    Motor Activity
    National Institutes of Health (U.S.)
    Obesity
    Pancreatic Neoplasms
    Proportional Hazards Models
    Prospective Studies
    Registries
    Risk Assessment
    Risk Factors
    Sex Factors
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    18270373

    Citation

    Stolzenberg-Solomon, Rachael Z., et al. "Adiposity, Physical Activity, and Pancreatic Cancer in the National Institutes of Health-AARP Diet and Health Cohort." American Journal of Epidemiology, vol. 167, no. 5, 2008, pp. 586-97.
    Stolzenberg-Solomon RZ, Adams K, Leitzmann M, et al. Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health Cohort. Am J Epidemiol. 2008;167(5):586-97.
    Stolzenberg-Solomon, R. Z., Adams, K., Leitzmann, M., Schairer, C., Michaud, D. S., Hollenbeck, A., ... Silverman, D. T. (2008). Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health Cohort. American Journal of Epidemiology, 167(5), pp. 586-97. doi:10.1093/aje/kwm361.
    Stolzenberg-Solomon RZ, et al. Adiposity, Physical Activity, and Pancreatic Cancer in the National Institutes of Health-AARP Diet and Health Cohort. Am J Epidemiol. 2008 Mar 1;167(5):586-97. PubMed PMID: 18270373.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health Cohort. AU - Stolzenberg-Solomon,Rachael Z, AU - Adams,Kenneth, AU - Leitzmann,Michael, AU - Schairer,Catherine, AU - Michaud,Dominique S, AU - Hollenbeck,Albert, AU - Schatzkin,Arthur, AU - Silverman,Debra T, Y1 - 2008/02/12/ PY - 2008/2/14/pubmed PY - 2008/3/26/medline PY - 2008/2/14/entrez SP - 586 EP - 97 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 167 IS - 5 N2 - Obesity and lack of physical activity have been inconsistently associated with pancreatic cancer. Using data from a self-administered baseline questionnaire (1995-1996), the authors investigated the association between adiposity and physical activity and pancreatic cancer in 495,035 participants of the National Institutes of Health-AARP Diet and Health Study who were aged 50-71 years. To avoid the influence of subclinical disease, follow-up time started 1 year after baseline, and subjects with a body mass index (BMI) of <18.5 kg/m(2) were excluded. A subcohort (n = 302,060) completed a second questionnaire with information about physical activity and waist and hip circumference. During follow-up though 2000, 654 pancreatic cancer cases were identified. The authors used Cox proportional hazard models to generate adjusted hazard ratios and 95% confidence intervals. Compared with those with a BMI of 18.5-<25, those with a BMI of >/=35 had a 45% greater pancreatic cancer risk (95% confidence interval (CI): 1.04, 2.02; p(trend) = 0.02). Significant positive associations for BMI were observed among nonsmokers (for BMI > or =35: hazard ratio = 1.70, 95% CI: 1.14, 2.53; p(trend) = 0.004) but not recent smokers (p(interaction) = 0.08). Waist circumference was positively associated with pancreatic cancer (fourth vs. first quartile: hazard ratio = 2.53, 95% CI: 1.13, 5.65; p(trend) = 0.04) in women but not men. The authors observed no association with physical activity. Their results suggest a positive association between adiposity and pancreatic cancer. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/18270373/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm361 DB - PRIME DP - Unbound Medicine ER -