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Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice.
J Pharmacol Sci 2008; 106(2):225-33JP

Abstract

This study examined the effects of gomisin A, a lignan compound from Schisandra fructus, on D-galactosamine (GalN) and lipopolysaccharide (LPS)-induced hepatic apoptosis and liver failure. Mice were given an intraperitoneal injection of GalN (700 mg/kg) / LPS (10 microg/kg). Gomisin A (25, 50, 100, and 200 mg/kg) was administered intraperitoneally 1 h before the GalN/LPS injection. The liver injury was assessed biochemically and histologically. GalN/LPS increased the serum aminotransferase levels and lipid peroxidation but decreased the reduced glutathione level. The pretreatment with gomisin A attenuated these changes in a dose-dependent manner. The survival rate of the gomisin A group was significantly higher than that of the control. The mitochondria isolated after the mice had been injected with GalN/LPS were swollen, which was attenuated by the gomisin A pretreatment. The elevation of serum tumor necrosis factor-alpha and activation of caspase-3 were observed in the GalN/LPS group, which was attenuated by gomisin A. The gomisin A-pretreated groups showed significantly fewer apoptotic (TUNEL-positive) cells and DNA fragmentation as compared with the GalN/LPS mice. The liver protection afforded by gomisin A is the result of the reduced oxidative stress and its anti-apoptotic activity.

Authors+Show Affiliations

College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18270473

Citation

Kim, Sung-Hwa, et al. "Anti-apoptotic and Hepatoprotective Effects of Gomisin a On Fulminant Hepatic Failure Induced By D-galactosamine and Lipopolysaccharide in Mice." Journal of Pharmacological Sciences, vol. 106, no. 2, 2008, pp. 225-33.
Kim SH, Kim YS, Kang SS, et al. Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice. J Pharmacol Sci. 2008;106(2):225-33.
Kim, S. H., Kim, Y. S., Kang, S. S., Bae, K., Hung, T. M., & Lee, S. M. (2008). Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice. Journal of Pharmacological Sciences, 106(2), pp. 225-33.
Kim SH, et al. Anti-apoptotic and Hepatoprotective Effects of Gomisin a On Fulminant Hepatic Failure Induced By D-galactosamine and Lipopolysaccharide in Mice. J Pharmacol Sci. 2008;106(2):225-33. PubMed PMID: 18270473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice. AU - Kim,Sung-Hwa, AU - Kim,Yeong Shik, AU - Kang,Sam Sik, AU - Bae,Kihwan, AU - Hung,Tran Manh, AU - Lee,Sun-Mee, Y1 - 2008/02/09/ PY - 2008/2/14/pubmed PY - 2008/5/23/medline PY - 2008/2/14/entrez SP - 225 EP - 33 JF - Journal of pharmacological sciences JO - J. Pharmacol. Sci. VL - 106 IS - 2 N2 - This study examined the effects of gomisin A, a lignan compound from Schisandra fructus, on D-galactosamine (GalN) and lipopolysaccharide (LPS)-induced hepatic apoptosis and liver failure. Mice were given an intraperitoneal injection of GalN (700 mg/kg) / LPS (10 microg/kg). Gomisin A (25, 50, 100, and 200 mg/kg) was administered intraperitoneally 1 h before the GalN/LPS injection. The liver injury was assessed biochemically and histologically. GalN/LPS increased the serum aminotransferase levels and lipid peroxidation but decreased the reduced glutathione level. The pretreatment with gomisin A attenuated these changes in a dose-dependent manner. The survival rate of the gomisin A group was significantly higher than that of the control. The mitochondria isolated after the mice had been injected with GalN/LPS were swollen, which was attenuated by the gomisin A pretreatment. The elevation of serum tumor necrosis factor-alpha and activation of caspase-3 were observed in the GalN/LPS group, which was attenuated by gomisin A. The gomisin A-pretreated groups showed significantly fewer apoptotic (TUNEL-positive) cells and DNA fragmentation as compared with the GalN/LPS mice. The liver protection afforded by gomisin A is the result of the reduced oxidative stress and its anti-apoptotic activity. SN - 1347-8613 UR - https://www.unboundmedicine.com/medline/citation/18270473/Anti_apoptotic_and_hepatoprotective_effects_of_gomisin_A_on_fulminant_hepatic_failure_induced_by_D_galactosamine_and_lipopolysaccharide_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/JST.JSTAGE/jphs/FP0071738 DB - PRIME DP - Unbound Medicine ER -