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Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography.
Psychopharmacology (Berl). 2008 May; 197(4):549-56.P

Abstract

INTRODUCTION

Cannabis users have been reported to have decreased regional cerebral glucose metabolism after short periods of abstinence. The purpose of this study was to measure striatal dopamine receptor (D2/D3) availability and cerebral glucose metabolism with positron emission tomography (PET) in young adults who had a prolonged exposure to cannabis and who had been abstinent for a period of at least 12 weeks.

MATERIALS AND METHODS

Six 18-21-year-old male subjects with cannabis dependence in early full remission and six age- and sex-matched healthy subjects underwent PET scans for D2/D3 receptor availability measured with [C11]-raclopride and glucose metabolism measured with [18F]-FDG. All subjects were sober for at least 12 weeks before PET scan procedures. PET data were analyzed with statistical parametric mapping software (SPM99; uncorrected p < 0.001, corrected p < 0.05 at the cluster level). Toxicology screening was performed prior to the PET scan to confirm the lack of drugs of abuse.

OBSERVATION AND RESULTS

Striatal D2/D3 receptor availability did not differ significantly between groups. Compared to controls, subjects with cannabis dependence had lower normalized glucose metabolism in the right orbitofrontal cortex, putamen bilaterally, and precuneus. There were no significant correlations between striatal D2/D3 receptor availability and normalized glucose metabolism in any region of the frontal cortex or striatum.

CONCLUSION

These findings may reflect both cannabis exposure and adaptive changes that occur after a prolonged period of abstinence. Subsequent studies should address whether metabolic and dopamine receptor effects are associated with either active use or longer-term withdrawal in these relatively young subjects.

Authors+Show Affiliations

The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, NY 11004, USA. Sevy@lij.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18270689

Citation

Sevy, Serge, et al. "Cerebral Glucose Metabolism and D2/D3 Receptor Availability in Young Adults With Cannabis Dependence Measured With Positron Emission Tomography." Psychopharmacology, vol. 197, no. 4, 2008, pp. 549-56.
Sevy S, Smith GS, Ma Y, et al. Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography. Psychopharmacology (Berl). 2008;197(4):549-56.
Sevy, S., Smith, G. S., Ma, Y., Dhawan, V., Chaly, T., Kingsley, P. B., Kumra, S., Abdelmessih, S., & Eidelberg, D. (2008). Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography. Psychopharmacology, 197(4), 549-56. https://doi.org/10.1007/s00213-008-1075-1
Sevy S, et al. Cerebral Glucose Metabolism and D2/D3 Receptor Availability in Young Adults With Cannabis Dependence Measured With Positron Emission Tomography. Psychopharmacology (Berl). 2008;197(4):549-56. PubMed PMID: 18270689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography. AU - Sevy,Serge, AU - Smith,Gwenn S, AU - Ma,Yilong, AU - Dhawan,Vijay, AU - Chaly,Thomas, AU - Kingsley,Peter B, AU - Kumra,Sanjiv, AU - Abdelmessih,Sherif, AU - Eidelberg,David, Y1 - 2008/02/13/ PY - 2007/10/05/received PY - 2007/12/27/accepted PY - 2008/2/14/pubmed PY - 2008/8/30/medline PY - 2008/2/14/entrez SP - 549 EP - 56 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 197 IS - 4 N2 - INTRODUCTION: Cannabis users have been reported to have decreased regional cerebral glucose metabolism after short periods of abstinence. The purpose of this study was to measure striatal dopamine receptor (D2/D3) availability and cerebral glucose metabolism with positron emission tomography (PET) in young adults who had a prolonged exposure to cannabis and who had been abstinent for a period of at least 12 weeks. MATERIALS AND METHODS: Six 18-21-year-old male subjects with cannabis dependence in early full remission and six age- and sex-matched healthy subjects underwent PET scans for D2/D3 receptor availability measured with [C11]-raclopride and glucose metabolism measured with [18F]-FDG. All subjects were sober for at least 12 weeks before PET scan procedures. PET data were analyzed with statistical parametric mapping software (SPM99; uncorrected p < 0.001, corrected p < 0.05 at the cluster level). Toxicology screening was performed prior to the PET scan to confirm the lack of drugs of abuse. OBSERVATION AND RESULTS: Striatal D2/D3 receptor availability did not differ significantly between groups. Compared to controls, subjects with cannabis dependence had lower normalized glucose metabolism in the right orbitofrontal cortex, putamen bilaterally, and precuneus. There were no significant correlations between striatal D2/D3 receptor availability and normalized glucose metabolism in any region of the frontal cortex or striatum. CONCLUSION: These findings may reflect both cannabis exposure and adaptive changes that occur after a prolonged period of abstinence. Subsequent studies should address whether metabolic and dopamine receptor effects are associated with either active use or longer-term withdrawal in these relatively young subjects. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/18270689/Cerebral_glucose_metabolism_and_D2/D3_receptor_availability_in_young_adults_with_cannabis_dependence_measured_with_positron_emission_tomography_ L2 - https://dx.doi.org/10.1007/s00213-008-1075-1 DB - PRIME DP - Unbound Medicine ER -