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[Randomized and controlled study on needling method of harmonizing spleen-stomach for early intervention of diabetic nephropathies and the mechanism of protecting kidney].
Zhongguo Zhen Jiu. 2007 Dec; 27(12):875-80.ZZ

Abstract

OBJECTIVE

To probe into clinical therapeutic effect of acupuncture on diabetic nephropathies and the mechanism.

METHODS

Using multi-central, randomized and blind methods, 130 cases of diabetic nephropathy were divided into an observation group and a control group, 65 cases in each group. They were treated by routine diabetic therapy, and in the observation group, acupuncture at Quchi (LI 11), Zhigou (TE 6), Hegu (LI 4), Xuehai (SP 10), Zusanli (ST 36), Yinlingquan (SP 9), Fenglong (ST 40), Diji (SP 8), Sanyinjiao (SP 6), Taichong (LR 3), Tianshu (ST 25), Gaohuang (BL 43), Shenshu (BL 23), Zhongwan (CV 12), Zhongji (CV 3) were added with needling method of harmonizing spleen-stomach. While in the control group, acupuncture at Shenshu (BL 23), Taixi (KI 3), Sanyingjiao (SP 6), Yanglingquan (GB 34), Xuanzhong (GB 39), Guanyuan (CV 4), Shousanli (LI 10), Waiguan (TE 5), Yangxi (LI 5), Liangqiu (ST 34), Shangjuxu (ST 37), Neiting (ST 44), Huaroumen (ST 24), Dachangshu (BL 25). The treatment was given twice a day in the two groups. Clinical therapeutic effects were assessed according to clinical symptoms and signs, blood sugar, blood lipids, urinary albumin excretion rate, urinary monocyte chemotactic protein-1 (MCP-1), glomerular filtration rate (GFR), renal blood flow, etc..

RESULTS

The needling method of harmonizing spleen-stomach not only could improve symptoms and signs of the patients, and also had benign regulative action on metabolism of blood sugar and lipids, and GFR, renal blood flow and urinary albumin level, with significant or very significant differences as compared with the control group (P < 0.05 or P < 0.01).

CONCLUSION

The needling method of harmonizing spleen-stomach is an effective method for diabetic nephropathies, which can improve progressive renal lesion induced by abnormal metabolism of blood sugar and lipids, improve renal blood flow and GFR, decrease urinary albumin secretion, inhibit over expression of MCP-1, protect glomerulus and renal tubules, so as to improve renal function and delay renal lesion.

Authors+Show Affiliations

Section of Acupuncture, Tianjin Hospital of TCM, Tianjin 300140, China. zhangzilongtj@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18271226

Citation

Zhang, Zhi-Long, et al. "[Randomized and Controlled Study On Needling Method of Harmonizing Spleen-stomach for Early Intervention of Diabetic Nephropathies and the Mechanism of Protecting Kidney]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 27, no. 12, 2007, pp. 875-80.
Zhang ZL, Ji XQ, Zhang P, et al. [Randomized and controlled study on needling method of harmonizing spleen-stomach for early intervention of diabetic nephropathies and the mechanism of protecting kidney]. Zhongguo Zhen Jiu. 2007;27(12):875-80.
Zhang, Z. L., Ji, X. Q., Zhang, P., Zhang, X. H., Meng, Z. J., & Yang, X. J. (2007). [Randomized and controlled study on needling method of harmonizing spleen-stomach for early intervention of diabetic nephropathies and the mechanism of protecting kidney]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 27(12), 875-80.
Zhang ZL, et al. [Randomized and Controlled Study On Needling Method of Harmonizing Spleen-stomach for Early Intervention of Diabetic Nephropathies and the Mechanism of Protecting Kidney]. Zhongguo Zhen Jiu. 2007;27(12):875-80. PubMed PMID: 18271226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Randomized and controlled study on needling method of harmonizing spleen-stomach for early intervention of diabetic nephropathies and the mechanism of protecting kidney]. AU - Zhang,Zhi-Long, AU - Ji,Xue-Qun, AU - Zhang,Ping, AU - Zhang,Xiu-Hong, AU - Meng,Zho-Jun, AU - Yang,Xiu-Juan, PY - 2008/2/15/pubmed PY - 2008/3/5/medline PY - 2008/2/15/entrez SP - 875 EP - 80 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 27 IS - 12 N2 - OBJECTIVE: To probe into clinical therapeutic effect of acupuncture on diabetic nephropathies and the mechanism. METHODS: Using multi-central, randomized and blind methods, 130 cases of diabetic nephropathy were divided into an observation group and a control group, 65 cases in each group. They were treated by routine diabetic therapy, and in the observation group, acupuncture at Quchi (LI 11), Zhigou (TE 6), Hegu (LI 4), Xuehai (SP 10), Zusanli (ST 36), Yinlingquan (SP 9), Fenglong (ST 40), Diji (SP 8), Sanyinjiao (SP 6), Taichong (LR 3), Tianshu (ST 25), Gaohuang (BL 43), Shenshu (BL 23), Zhongwan (CV 12), Zhongji (CV 3) were added with needling method of harmonizing spleen-stomach. While in the control group, acupuncture at Shenshu (BL 23), Taixi (KI 3), Sanyingjiao (SP 6), Yanglingquan (GB 34), Xuanzhong (GB 39), Guanyuan (CV 4), Shousanli (LI 10), Waiguan (TE 5), Yangxi (LI 5), Liangqiu (ST 34), Shangjuxu (ST 37), Neiting (ST 44), Huaroumen (ST 24), Dachangshu (BL 25). The treatment was given twice a day in the two groups. Clinical therapeutic effects were assessed according to clinical symptoms and signs, blood sugar, blood lipids, urinary albumin excretion rate, urinary monocyte chemotactic protein-1 (MCP-1), glomerular filtration rate (GFR), renal blood flow, etc.. RESULTS: The needling method of harmonizing spleen-stomach not only could improve symptoms and signs of the patients, and also had benign regulative action on metabolism of blood sugar and lipids, and GFR, renal blood flow and urinary albumin level, with significant or very significant differences as compared with the control group (P < 0.05 or P < 0.01). CONCLUSION: The needling method of harmonizing spleen-stomach is an effective method for diabetic nephropathies, which can improve progressive renal lesion induced by abnormal metabolism of blood sugar and lipids, improve renal blood flow and GFR, decrease urinary albumin secretion, inhibit over expression of MCP-1, protect glomerulus and renal tubules, so as to improve renal function and delay renal lesion. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/18271226/[Randomized_and_controlled_study_on_needling_method_of_harmonizing_spleen_stomach_for_early_intervention_of_diabetic_nephropathies_and_the_mechanism_of_protecting_kidney]_ L2 - https://medlineplus.gov/diabetickidneyproblems.html DB - PRIME DP - Unbound Medicine ER -