Tags

Type your tag names separated by a space and hit enter

Immunohistologic and ultrastructural comparison of the dermal papilla and hair follicle bulb from "active" and "normal" areas of alopecia areata.
J Invest Dermatol. 1991 May; 96(5):673-81.JI

Abstract

The "active" edges of patches of alopecia areata and normal areas from the same scalp (i.e., bearing normal terminal hair) from seven patients with alopecia areata were investigated immunohistologically. Similar areas from a further eight patients were examined using light and electronmicroscopy. "Active" and "normal" areas of alopecia areata scalps were immunohistologically similar and varied from normal controls in the number, distribution, and ratio for T4 and T8-positive cells. Similarly the ultrastructural changes seen in the "active" areas when compared to normal controls were also present in the "normal" areas of alopecia areata scalps. The most significant differences found between normal "control" follicles and both "active" and "normal" areas of alopecia areata scalps were the polymorphic nature of the dermal papilla cells and the loss of cellular organization within the dermal papillae taken from alopecia areata scalps. In addition, the junction between the dermal papilla and the bulb of the hair follicle, the dermo-epithelial junction of the hair follicle bulb, demonstrated critical changes in follicles taken from both "active" and "normal" areas of alopecia areata scalps. These results support the suggestion of a subclinical state of alopecia areata and indicate that further work on the etiology of alopecia areata should be directed towards the "normal" areas of alopecia areata scalps, in particular the cells of the dermal papilla and the dermo-epithelial junction of the hair follicle bulb.

Authors+Show Affiliations

Hull SM
Department of Dermatology, General Infirmary, Leeds, England.
Nutbrown M
No affiliation info available
Pepall L
No affiliation info available
Thornton MJ
No affiliation info available
Randall VA
No affiliation info available
Cunliffe WJ
No affiliation info available

MeSH

AdultAlopecia AreataFemaleHairHumansMaleMicroscopy, ElectronMiddle AgedSkinT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerT-Lymphocytes, Regulatory

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1827135

Citation

Hull, S M., et al. "Immunohistologic and Ultrastructural Comparison of the Dermal Papilla and Hair Follicle Bulb From "active" and "normal" Areas of Alopecia Areata." The Journal of Investigative Dermatology, vol. 96, no. 5, 1991, pp. 673-81.
Hull SM, Nutbrown M, Pepall L, et al. Immunohistologic and ultrastructural comparison of the dermal papilla and hair follicle bulb from "active" and "normal" areas of alopecia areata. J Invest Dermatol. 1991;96(5):673-81.
Hull, S. M., Nutbrown, M., Pepall, L., Thornton, M. J., Randall, V. A., & Cunliffe, W. J. (1991). Immunohistologic and ultrastructural comparison of the dermal papilla and hair follicle bulb from "active" and "normal" areas of alopecia areata. The Journal of Investigative Dermatology, 96(5), 673-81.
Hull SM, et al. Immunohistologic and Ultrastructural Comparison of the Dermal Papilla and Hair Follicle Bulb From "active" and "normal" Areas of Alopecia Areata. J Invest Dermatol. 1991;96(5):673-81. PubMed PMID: 1827135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistologic and ultrastructural comparison of the dermal papilla and hair follicle bulb from "active" and "normal" areas of alopecia areata. AU - Hull,S M, AU - Nutbrown,M, AU - Pepall,L, AU - Thornton,M J, AU - Randall,V A, AU - Cunliffe,W J, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 673 EP - 81 JF - The Journal of investigative dermatology JO - J Invest Dermatol VL - 96 IS - 5 N2 - The "active" edges of patches of alopecia areata and normal areas from the same scalp (i.e., bearing normal terminal hair) from seven patients with alopecia areata were investigated immunohistologically. Similar areas from a further eight patients were examined using light and electronmicroscopy. "Active" and "normal" areas of alopecia areata scalps were immunohistologically similar and varied from normal controls in the number, distribution, and ratio for T4 and T8-positive cells. Similarly the ultrastructural changes seen in the "active" areas when compared to normal controls were also present in the "normal" areas of alopecia areata scalps. The most significant differences found between normal "control" follicles and both "active" and "normal" areas of alopecia areata scalps were the polymorphic nature of the dermal papilla cells and the loss of cellular organization within the dermal papillae taken from alopecia areata scalps. In addition, the junction between the dermal papilla and the bulb of the hair follicle, the dermo-epithelial junction of the hair follicle bulb, demonstrated critical changes in follicles taken from both "active" and "normal" areas of alopecia areata scalps. These results support the suggestion of a subclinical state of alopecia areata and indicate that further work on the etiology of alopecia areata should be directed towards the "normal" areas of alopecia areata scalps, in particular the cells of the dermal papilla and the dermo-epithelial junction of the hair follicle bulb. SN - 0022-202X UR - https://www.unboundmedicine.com/medline/citation/1827135/Immunohistologic_and_ultrastructural_comparison_of_the_dermal_papilla_and_hair_follicle_bulb_from_"active"_and_"normal"_areas_of_alopecia_areata_ DB - PRIME DP - Unbound Medicine ER -