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Community-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong.
Diagn Microbiol Infect Dis. 2008 Jul; 61(3):245-50.DM

Abstract

This prospective study assessed the epidemiology of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) among patients with purulent skin and soft tissue infections (SSTIs) in Hong Kong. Among 298 patients with SSTIs, 10.4% (13/125) of all S. aureus isolates and 5% (12/241) of all abscesses were attributed to pvl-positive CA-MRSA. Overall, 77% and 69.9% of CA-MRSA and methicillin-sensitive S. aureus (MSSA) were susceptible to erythromycin, 77% and 74.8% to clindamycin, 100% and 97.1% to minocycline, and 100% and 98.1% to rifampin, respectively. Filipino ethnicity was the only clinical and epidemiologic factor significantly associated with CA-MRSA infection (odds ratio, 14.8; 95% confidence interval, 3.3-70.0; P < 0.001). Pulsed-field gel electrophoresis analysis showed that 6 CA-MRSA isolates belonged to the ST30-HKU100 clone, 5 belonged to the ST59-HKU200 clone, and 1 was singleton. Features of HKU100 isolates include SCCmec type IV, agr3, spa t019, and pan-susceptibility to non-beta-lactam antibiotics. In contrast, HKU200 isolates are characterized by having SCCmec type IV or V, agr4, spa t437, and variable non-beta-lactam susceptibility profiles. The major CA-MRSA spa types were shared by a minority of the MSSA.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Microbiology and Centre of Infection, The University of Hong Kong, Hong Kong SAR, China. plho@hkucc.hku.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18272316

Citation

Ho, Pak-Leung, et al. "Community-associated Methicillin-resistant and Methicillin-sensitive Staphylococcus Aureus: Skin and Soft Tissue Infections in Hong Kong." Diagnostic Microbiology and Infectious Disease, vol. 61, no. 3, 2008, pp. 245-50.
Ho PL, Chuang SK, Choi YF, et al. Community-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong. Diagn Microbiol Infect Dis. 2008;61(3):245-50.
Ho, P. L., Chuang, S. K., Choi, Y. F., Lee, R. A., Lit, A. C., Ng, T. K., Que, T. L., Shek, K. C., Tong, H. K., Tse, C. W., Tung, W. K., & Yung, R. W. (2008). Community-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong. Diagnostic Microbiology and Infectious Disease, 61(3), 245-50. https://doi.org/10.1016/j.diagmicrobio.2007.12.015
Ho PL, et al. Community-associated Methicillin-resistant and Methicillin-sensitive Staphylococcus Aureus: Skin and Soft Tissue Infections in Hong Kong. Diagn Microbiol Infect Dis. 2008;61(3):245-50. PubMed PMID: 18272316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Community-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong. AU - Ho,Pak-Leung, AU - Chuang,Shuk-Kwan, AU - Choi,Yu-Fai, AU - Lee,Rodney A, AU - Lit,Albert C H, AU - Ng,Tak-Keung, AU - Que,Tak-Lun, AU - Shek,Kam-Chuen, AU - Tong,Hon-Kuan, AU - Tse,Cindy W S, AU - Tung,Wai-Kit, AU - Yung,Raymond W H, AU - ,, Y1 - 2008/02/12/ PY - 2007/11/19/received PY - 2007/12/19/revised PY - 2007/12/25/accepted PY - 2008/2/15/pubmed PY - 2008/9/5/medline PY - 2008/2/15/entrez SP - 245 EP - 50 JF - Diagnostic microbiology and infectious disease JO - Diagn. Microbiol. Infect. Dis. VL - 61 IS - 3 N2 - This prospective study assessed the epidemiology of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) among patients with purulent skin and soft tissue infections (SSTIs) in Hong Kong. Among 298 patients with SSTIs, 10.4% (13/125) of all S. aureus isolates and 5% (12/241) of all abscesses were attributed to pvl-positive CA-MRSA. Overall, 77% and 69.9% of CA-MRSA and methicillin-sensitive S. aureus (MSSA) were susceptible to erythromycin, 77% and 74.8% to clindamycin, 100% and 97.1% to minocycline, and 100% and 98.1% to rifampin, respectively. Filipino ethnicity was the only clinical and epidemiologic factor significantly associated with CA-MRSA infection (odds ratio, 14.8; 95% confidence interval, 3.3-70.0; P < 0.001). Pulsed-field gel electrophoresis analysis showed that 6 CA-MRSA isolates belonged to the ST30-HKU100 clone, 5 belonged to the ST59-HKU200 clone, and 1 was singleton. Features of HKU100 isolates include SCCmec type IV, agr3, spa t019, and pan-susceptibility to non-beta-lactam antibiotics. In contrast, HKU200 isolates are characterized by having SCCmec type IV or V, agr4, spa t437, and variable non-beta-lactam susceptibility profiles. The major CA-MRSA spa types were shared by a minority of the MSSA. SN - 0732-8893 UR - https://www.unboundmedicine.com/medline/citation/18272316/Community_associated_methicillin_resistant_and_methicillin_sensitive_Staphylococcus_aureus:_skin_and_soft_tissue_infections_in_Hong_Kong_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0732-8893(08)00003-5 DB - PRIME DP - Unbound Medicine ER -