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A selected ion flow tube mass spectrometry study of ammonia in mouth- and nose-exhaled breath and in the oral cavity.
Rapid Commun Mass Spectrom. 2008; 22(6):783-9.RC

Abstract

A study has been carried out, involving three healthy volunteers, of the ammonia levels in breath exhaled via the mouth and via the nose and in the static oral cavity using on-line, selected ion flow tube mass spectrometry (SIFT-MS), obviating the problems associated with sample collection of ammonia. The unequivocal conclusion drawn is that the ammonia appearing in the mouth-exhaled breath of the three volunteers is largely generated in the oral cavity and that the ammonia originating at the alveolar interface in the lungs is typically at levels less than about 100 parts-per-billion, which is a small fraction of the total breath ammonia. This leads to the recommendation that exhaled breath analyses should focus on nose-exhaled breath if the objective is to use breath analysis to investigate systemic, metabolic disease.

Authors+Show Affiliations

Institute for Science and Technology in Medicine, School of Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB, UK. d.smith@bemp.keele.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

18275096

Citation

Smith, David, et al. "A Selected Ion Flow Tube Mass Spectrometry Study of Ammonia in Mouth- and Nose-exhaled Breath and in the Oral Cavity." Rapid Communications in Mass Spectrometry : RCM, vol. 22, no. 6, 2008, pp. 783-9.
Smith D, Wang T, Pysanenko A, et al. A selected ion flow tube mass spectrometry study of ammonia in mouth- and nose-exhaled breath and in the oral cavity. Rapid Commun Mass Spectrom. 2008;22(6):783-9.
Smith, D., Wang, T., Pysanenko, A., & Spanel, P. (2008). A selected ion flow tube mass spectrometry study of ammonia in mouth- and nose-exhaled breath and in the oral cavity. Rapid Communications in Mass Spectrometry : RCM, 22(6), 783-9. https://doi.org/10.1002/rcm.3434
Smith D, et al. A Selected Ion Flow Tube Mass Spectrometry Study of Ammonia in Mouth- and Nose-exhaled Breath and in the Oral Cavity. Rapid Commun Mass Spectrom. 2008;22(6):783-9. PubMed PMID: 18275096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A selected ion flow tube mass spectrometry study of ammonia in mouth- and nose-exhaled breath and in the oral cavity. AU - Smith,David, AU - Wang,Tianshu, AU - Pysanenko,Andriy, AU - Spanel,Patrik, PY - 2008/2/16/pubmed PY - 2008/5/30/medline PY - 2008/2/16/entrez SP - 783 EP - 9 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 22 IS - 6 N2 - A study has been carried out, involving three healthy volunteers, of the ammonia levels in breath exhaled via the mouth and via the nose and in the static oral cavity using on-line, selected ion flow tube mass spectrometry (SIFT-MS), obviating the problems associated with sample collection of ammonia. The unequivocal conclusion drawn is that the ammonia appearing in the mouth-exhaled breath of the three volunteers is largely generated in the oral cavity and that the ammonia originating at the alveolar interface in the lungs is typically at levels less than about 100 parts-per-billion, which is a small fraction of the total breath ammonia. This leads to the recommendation that exhaled breath analyses should focus on nose-exhaled breath if the objective is to use breath analysis to investigate systemic, metabolic disease. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/18275096/A_selected_ion_flow_tube_mass_spectrometry_study_of_ammonia_in_mouth__and_nose_exhaled_breath_and_in_the_oral_cavity_ L2 - https://doi.org/10.1002/rcm.3434 DB - PRIME DP - Unbound Medicine ER -