Tags

Type your tag names separated by a space and hit enter

Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men.
Br J Nutr. 2008 Jul; 100(1):159-65.BJ

Abstract

Traditional cardiovascular risk factors are associated with endothelial dysfunction. The vascular endothelium plays a key role in local vascular tone regulation and can be modulated by dietary fat. We propose to determine the chronic effect of three diets with different fat compositions on postprandial endothelial function and inflammatory biomarkers. Twenty healthy men followed three 4-week diets in a randomised cross-over design: a Western diet, rich in saturated fat (22% SFA, 12% MUFA and 0.4% alpha-linolenic acid (ALA), all fractions are % of energy); a Mediterranean diet, rich in MUFA (< 10 % SFA, 24 % MUFA and 0.4% ALA); a low-fat diet enriched in ALA (< 10% SFA, 12% MUFA and 2% ALA). At the end of each dietary period all subjects underwent a postprandial study. Plasma concentrations of lipid parameters, soluble intercellular cell-adhesion molecule-1, soluble vascular cell-adhesion molecule-1 (sVCAM-1), nitrates and nitrites (NOx) and endothelial function studied by laser Doppler were examined at 0, 2, 4, 6 and 8 h. The endothelium-dependent vasodilatory response was greater 4 h after the ingestion of the MUFA-rich diet than after the SFA or ALA low-fat diets (P = 0.031). The 4 h postprandial plasma sVCAM-1 levels were lower after the MUFA meals than after the ALA low-fat diet (P = 0.043). The bioavailability of NOx was higher following the MUFA diet than after the SFA and ALA low-fat diets (P = 0.027). We found no differences in the other parameters measured. Chronic ingestion of a Mediterranean diet avoids the postprandial deterioration of endothelial function associated with Westernised diets in healthy individuals.

Authors+Show Affiliations

Lipid and Atherosclerosis Unit, Internal Medicine Service, Reina Sofía University Hospital, Avenida Menéndez Pidal s/n, Córdoba 14004, Spain. fjfuentesjimenez@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18275619

Citation

Fuentes, F, et al. "Chronic Effects of a High-fat Diet Enriched With Virgin Olive Oil and a Low-fat Diet Enriched With Alpha-linolenic Acid On Postprandial Endothelial Function in Healthy Men." The British Journal of Nutrition, vol. 100, no. 1, 2008, pp. 159-65.
Fuentes F, López-Miranda J, Pérez-Martínez P, et al. Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men. Br J Nutr. 2008;100(1):159-65.
Fuentes, F., López-Miranda, J., Pérez-Martínez, P., Jiménez, Y., Marín, C., Gómez, P., Fernández, J. M., Caballero, J., Delgado-Lista, J., & Pérez-Jiménez, F. (2008). Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men. The British Journal of Nutrition, 100(1), 159-65. https://doi.org/10.1017/S0007114508888708
Fuentes F, et al. Chronic Effects of a High-fat Diet Enriched With Virgin Olive Oil and a Low-fat Diet Enriched With Alpha-linolenic Acid On Postprandial Endothelial Function in Healthy Men. Br J Nutr. 2008;100(1):159-65. PubMed PMID: 18275619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men. AU - Fuentes,F, AU - López-Miranda,J, AU - Pérez-Martínez,P, AU - Jiménez,Y, AU - Marín,C, AU - Gómez,P, AU - Fernández,J M, AU - Caballero,J, AU - Delgado-Lista,J, AU - Pérez-Jiménez,F, Y1 - 2008/02/14/ PY - 2008/2/16/pubmed PY - 2009/1/20/medline PY - 2008/2/16/entrez SP - 159 EP - 65 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 100 IS - 1 N2 - Traditional cardiovascular risk factors are associated with endothelial dysfunction. The vascular endothelium plays a key role in local vascular tone regulation and can be modulated by dietary fat. We propose to determine the chronic effect of three diets with different fat compositions on postprandial endothelial function and inflammatory biomarkers. Twenty healthy men followed three 4-week diets in a randomised cross-over design: a Western diet, rich in saturated fat (22% SFA, 12% MUFA and 0.4% alpha-linolenic acid (ALA), all fractions are % of energy); a Mediterranean diet, rich in MUFA (< 10 % SFA, 24 % MUFA and 0.4% ALA); a low-fat diet enriched in ALA (< 10% SFA, 12% MUFA and 2% ALA). At the end of each dietary period all subjects underwent a postprandial study. Plasma concentrations of lipid parameters, soluble intercellular cell-adhesion molecule-1, soluble vascular cell-adhesion molecule-1 (sVCAM-1), nitrates and nitrites (NOx) and endothelial function studied by laser Doppler were examined at 0, 2, 4, 6 and 8 h. The endothelium-dependent vasodilatory response was greater 4 h after the ingestion of the MUFA-rich diet than after the SFA or ALA low-fat diets (P = 0.031). The 4 h postprandial plasma sVCAM-1 levels were lower after the MUFA meals than after the ALA low-fat diet (P = 0.043). The bioavailability of NOx was higher following the MUFA diet than after the SFA and ALA low-fat diets (P = 0.027). We found no differences in the other parameters measured. Chronic ingestion of a Mediterranean diet avoids the postprandial deterioration of endothelial function associated with Westernised diets in healthy individuals. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/18275619/Chronic_effects_of_a_high_fat_diet_enriched_with_virgin_olive_oil_and_a_low_fat_diet_enriched_with_alpha_linolenic_acid_on_postprandial_endothelial_function_in_healthy_men_ L2 - https://www.cambridge.org/core/product/identifier/S0007114508888708/type/journal_article DB - PRIME DP - Unbound Medicine ER -